Replication Data for: Albumin-dependent and independent mechanisms in the syndrome of kwashiorkor

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Gonzales, Gerard B.; Njunge, James M.; Gichuki, Bonface M.; Wen, Bijun; Ngari, Moses M.; Potani, Isabel; Thitiri, Johnstone; Laukens, Debby; Vanmassenhove, Jill; Voskuijl, Wieger; Bandsma, Robert H.J.; Berkley, James A., 2021, "Replication Data for: Albumin-dependent and independent mechanisms in the syndrome of kwashiorkor", https://doi.org/10.7910/DVN/NQCN2E, Harvard Dataverse, V1, UNF:6:9mBhiyYv1F5GG/snTGNJaA== [fileUNF]
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Description

This is a replication dataset for the manuscript titled: "Albumin-dependent and independent mechanisms in the syndrome of kwashiorkor."

Our aim was to determine albumin-independent differences in pathophysiology between Severe wasting and kwashiorkor to inform targeted prevention and treatment strategies . We used the F75 reformulation clinical trail to discover mechanisms that distinguish severe wasting from kwashiorkor beyond albumin. This sub-cohort comprised children with kwashiorkor and marasmus who had been matched on exact serum albumin levels. Plasma samples from the discovery sub-cohort were subjected to untargeted liquid chromatography tandem mass tag (TMT)-based proteomics and targeted metabolomics (Biocrates™ p 180). Other targeted assays included ELISA and Luminex. The findings from the discovery cohort were validated using a subset of the daily cotrimoxazole trial data and samples.

Subject Medicine, Health and Life Sciences
Keyword kwashiorkor, severe acute malnutrition, oedematous severe malnutrition, proteomics, metabolomics
Related Publication Berkley, J.A., Ngari, M., Thitiri, J., Mwalekwa, L., Timbwa, M., Hamid, F., Ali, R., Shangala, J., Mturi, N., Jones, K.D. and Alphan, H., 2016. Daily co-trimoxazole prophylaxis to prevent mortality in children with complicated severe acute malnutrition: a multicentre, double-blind, randomised placebo-controlled trial. The Lancet Global Health, 4(7), pp.e464-e473. doi: 10.1016/S2214-109X(16)30096-1doi: https://doi.org/10.1016/S2214-109X(16)30096-1
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