Replication Data for: Plasmodium falciparum adapts investment into replication versus reproduction transmission according to host environment (doi:10.7910/DVN/BXXVRY)

View:

Part 1: Document Description
Part 2: Study Description
Part 3: Data Files Description
Part 4: Variable Description
Part 5: Other Study-Related Materials
Entire Codebook

Document Description

Citation

Title:

Replication Data for: Plasmodium falciparum adapts investment into replication versus reproduction transmission according to host environment

Identification Number:

doi:10.7910/DVN/BXXVRY

Distributor:

Harvard Dataverse

Date of Distribution:

2022-11-17

Version:

2

Bibliographic Citation:

Abdi, Abdirahman I.; Achcar, Fiona; Sollelis, Lauriane; Silva-Filho, Joao L.; Mwikali, Kioko; Muthui, Michelle; Mwangi, Shaban; Kimingi, Hannah W.; Orindi, Benedict; Kivisi, Cheryl Andisi; Alkema,Manon; Chandrasekar, Amrita; Bull, Peter C.; Bejon,Philip; Modrzynska,Kaarzyna; Bousema, Teun; Marti, Matthias, 2022, "Replication Data for: Plasmodium falciparum adapts investment into replication versus reproduction transmission according to host environment", https://doi.org/10.7910/DVN/BXXVRY, Harvard Dataverse, V2, UNF:6:uD14tRF+X1o1d56q2BdgGg== [fileUNF]

Study Description

Citation

Title:

Replication Data for: Plasmodium falciparum adapts investment into replication versus reproduction transmission according to host environment

Identification Number:

doi:10.7910/DVN/BXXVRY

Authoring Entity:

Abdi, Abdirahman I. (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya)

Achcar, Fiona (Wellcome Center for Integrative Parasitology, Institute of Infection and Immunity, University of Glasgow, Glasgow. Scotland, UK)

Sollelis, Lauriane (Wellcome Center for Integrative Parasitology, Institute of Infection and Immunity, University of Glasgow, Glasgow. Scotland, UK)

Silva-Filho, Joao L. (Wellcome Center for Integrative Parasitology, Institute of Infection and Immunity, University of Glasgow, Glasgow. Scotland, UK)

Mwikali, Kioko (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya)

Muthui, Michelle (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya)

Mwangi, Shaban (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya)

Kimingi, Hannah W. (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya)

Orindi, Benedict (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya)

Kivisi, Cheryl Andisi (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya)

Alkema,Manon (Radboud University Medical Center, Nijmegen, The Netherlands)

Chandrasekar, Amrita (Wellcome Center for Integrative Parasitology, Institute of Infection and Immunity, University of Glasgow, Glasgow. Scotland, UK)

Bull, Peter C. (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya)

Bejon,Philip (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya)

Modrzynska,Kaarzyna (Wellcome Center for Integrative Parasitology, Institute of Infection and Immunity, University of Glasgow, Glasgow. Scotland, UK)

Bousema, Teun (Radboud University Medical Center, Nijmegen, The Netherlands)

Marti, Matthias (Wellcome Center for Integrative Parasitology, Institute of Infection and Immunity, University of Glasgow, Glasgow. Scotland, UK)

Distributor:

Harvard Dataverse

Access Authority:

Abdi, Abdirahman I.

Depositor:

Abdi, Abdirahman I.

Date of Deposit:

2022-11-09

Holdings Information:

https://doi.org/10.7910/DVN/BXXVRY

Study Scope

Keywords:

Medicine, Health and Life Sciences

Abstract:

<p>The dataset contains sequence data used to publish findings in the manuscript titled: "<a href="">Plasmodium falciparum adapts investment into replication versus reproduction transmission according to host environment</a>" submitted to ELife Journal.</p> <p>The data was generated to investigate the impact of host inflammatory response on the infecting malaria parasites. The study used clinical data collected from children presenting with malaria (1994-2014), gene transcription (ap2g, pfsir2a, pfs16) of the parasites isolated from the children, plasma level of PfHRP2, 34 inflammatory markers and lipidome</p>

Kind of Data:

Restricted Access

Notes:

<p><strong>Data Access: </strong>Restricted</p> <p>Access to these data requires submission of a formal request for consideration by our Data Governance Committee. </p> <strong>How to request</strong> <ol> <li>Download and complete the <a href="https://kemri-wellcome.org/zp-content/uploads/2021/02/KWTRP_Dataverse_Data_Request_Form_2019.docx"><strong>data request form</strong></a></li> <li> Email completed data request form to the Data Governance Committee at <a href="mailto:dgc@kemri-wellcome.org?cc=lmwango@kemri-wellcome.org?Subject=Data%20Access%20Request"><strong>dgc@kemri-wellcome.org</strong></a> </li> </ol> <p><strong>License: </strong><a href="https://creativecommons.org/licenses/by/4.0/legalcode">Creative Commons Attribution 4.0 International</a> <a href="https://creativecommons.org/licenses/by/4.0/legalcode"><img src="https://i.creativecommons.org/l/by/3.0/88x31.png"> </a></p>

Methodology and Processing

Sources Statement

Data Access

Citation Requirement:

<p>Publications based on this data collection should acknowledge this source by means of bibliographic citation.</p>

Notes:

<p>This data is licensed under the <a href="https://creativecommons.org/licenses/by/4.0/legalcode">Creative Commons Attribution 4.0 International</a> <a href="https://creativecommons.org/licenses/by/4.0/legalcode"><img src="https://i.creativecommons.org/l/by/3.0/88x31.png"> </a> </p>

For access to restricted data, there is a process of managed access requiring submission of a request form for consideration by our Data Governance Committee. Please send a signed data request form to [<a href="mailto:dgc@kemri-wellcome.org">dgc@kemri-wellcome.org</a> ]. <strong> <a href="https://kemri-wellcome.org/zp-content/uploads/2021/02/KWTRP_Dataverse_Data_Request_Form_2019.docx">Click to download Data Request Form</a></strong>

Other Study Description Materials

File Description--f6710229

File: Final_groups_with_batch.tab

  • Number of cases: 269

  • No. of variables per record: 8

  • Type of File: text/tab-separated-values

Notes:

UNF:6:Hoba/XyhK+M/52ProJVMSQ==

File Description--f6710228

File: lipidomics_idsAnnot.tab

  • Number of cases: 3448

  • No. of variables per record: 6

  • Type of File: text/tab-separated-values

Notes:

UNF:6:SfU6/sxLnVAeIRT5Epla1Q==

File Description--f6710218

File: malaria_positives_and_mean_age.tab

  • Number of cases: 19

  • No. of variables per record: 3

  • Type of File: text/tab-separated-values

Notes:

UNF:6:pkBchAA6fylxWvKo8OXPaA==

Variable Description

List of Variables:

Variables

pid

f6710229 Location:

Variable Format: character

Notes: UNF:6:vkpyw2QUqoSjMmazHYqOmA==

year

f6710229 Location:

Summary Statistics: Mean 2008.375; StDev 4.558981654436678; Valid 256.0; Min. 1995.0; Max. 2012.0;

Variable Format: numeric

Notes: UNF:6:50Z1e2z8hQIpkw4Wi8GuRg==

clinclass

f6710229 Location:

Variable Format: character

Notes: UNF:6:h7TsjoWIG/t7wcSq0fOcbg==

temp

f6710229 Location:

Summary Statistics: Valid 269.0; Mean 38.331970275092935; Min. 35.099998; StDev 1.1554301129540523; Max. 40.799999

Variable Format: numeric

Notes: UNF:6:usvswe9BJI7TRGPhg07BlA==

parasit_log

f6710229 Location:

Summary Statistics: Mean 4.95006016616829; Max. 6.18202669589275; StDev 0.8611052645283892; Min. 0.0; Valid 241.0;

Variable Format: numeric

Notes: UNF:6:JzUL4XxE47Zf9TjusKyGSQ==

ap2_log

f6710229 Location:

Summary Statistics: Max. 4.9025669; StDev 1.7317626244975235; Min. -4.9416456; Valid 269.0; Mean 0.23825186275873605

Variable Format: numeric

Notes: UNF:6:pxyk1F341e2FzQgw2AE4hQ==

group

f6710229 Location:

Variable Format: character

Notes: UNF:6:OohAQdkjYjubbE7CXSi14Q==

batch

f6710229 Location:

Variable Format: character

Notes: UNF:6:F51td3I5j3E9HypszXzo1Q==

id

f6710228 Location:

Variable Format: character

Notes: UNF:6:ewpU8mRTetyffoN41xZRfA==

Note

f6710228 Location:

Variable Format: character

Notes: UNF:6:QR0nGYriv0CbjK6cXg+oMA==

Name

f6710228 Location:

Variable Format: character

Notes: UNF:6:AKwknoEIzHT8TRdCpk4Bsg==

Type

f6710228 Location:

Variable Format: character

Notes: UNF:6:W1RJ8MOs6xxQn0PvRTaaog==

mass

f6710228 Location:

Summary Statistics: Max. 996.8170809; Mean 407.6235696951276; Valid 3448.0; Min. 70.06522228; StDev 237.51458463418797

Variable Format: numeric

Notes: UNF:6:T2v3QX6x3+3lzF5HCLycGg==

RT

f6710228 Location:

Summary Statistics: StDev 521.9727937457842; Max. 2382.085262; Mean 637.259498171105; Valid 3448.0; Min. 44.14809988

Variable Format: numeric

Notes: UNF:6:OUNPkh673LuQZExMgJTGFA==

year

f6710218 Location:

Summary Statistics: Mean 2003.0; Valid 19.0; StDev 5.627314338711377; Min. 1994.0; Max. 2012.0;

Variable Format: numeric

Notes: UNF:6:wrIzy4xRVBgA4idzcYYdyQ==

freq

f6710218 Location:

Summary Statistics: Max. 2749.0; Valid 19.0; Min. 262.0; StDev 845.9388915206194; Mean 1411.9473684210527

Variable Format: numeric

Notes: UNF:6:Gel+7Wz1KYwZfakGQvY5Wg==

nagem

f6710218 Location:

Summary Statistics: Min. 25.06822058; Mean 37.278471714210525; StDev 8.829428971880557; Max. 55.07038835; Valid 19.0;

Variable Format: numeric

Notes: UNF:6:Ot+BJ5O0vFQdIgVi5gZp8g==

Other Study-Related Materials

Label:

Abdi_Pfalciparum_replicationVStransmission_readme.txt

Notes:

text/plain

Other Study-Related Materials

Label:

All_data_raw_merged.tsv

Text:

Metadata, qPCR, Luminex and preprocessed lipidomics data

Notes:

text/tsv

Other Study-Related Materials

Label:

forpublication.R

Notes:

type/x-r-syntax