Replication Data for: Breadth of antibodies to Plasmodium falciparum variant surface antigens is associated with immunity in a controlled human malaria infection study (doi:10.7910/DVN/AYWX0Y)

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Replication Data for: Breadth of antibodies to Plasmodium falciparum variant surface antigens is associated with immunity in a controlled human malaria infection study

doi:10.7910/DVN/AYWX0Y

Harvard Dataverse

2022-02-17

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Kinyua, Ann; Kinyanjui, Samson, 2022, "Replication Data for: Breadth of antibodies to Plasmodium falciparum variant surface antigens is associated with immunity in a controlled human malaria infection study", https://doi.org/10.7910/DVN/AYWX0Y, Harvard Dataverse, V2

Replication Data for: Breadth of antibodies to Plasmodium falciparum variant surface antigens is associated with immunity in a controlled human malaria infection study

doi:10.7910/DVN/AYWX0Y

Kinyua, Ann (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya)

Kinyanjui, Samson (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya)

Harvard Dataverse

Kinyua, Ann

Kinyua, Ann

2022-02-17

https://doi.org/10.7910/DVN/AYWX0Y

Medicine, Health and Life Sciences, Medicine, Health and Life Sciences

<p>This is a replication dataset for the manuscript titled: "<a href="">Breadth of antibodies to Plasmodium falciparum variant surface antigens is associated with immunity in a controlled human malaria infection study</a>." </p>

<p><strong>Data Access: </strong>Restricted</p> <p>Access to these data requires submission of a formal request for consideration by our Data Governance Committee. </p> <strong>How to request</strong> <ol> <li>Download and complete the <a href="https://kemri-wellcome.org/zp-content/uploads/2021/02/KWTRP_Dataverse_Data_Request_Form_2019.docx"><strong>data request form</strong></a></li> <li> Email completed data request form to the Data Governance Committee at <a href="mailto:dgc@kemri-wellcome.org?cc=lmwango@kemri-wellcome.org?Subject=Data%20Access%20Request"><strong>dgc@kemri-wellcome.org</strong></a> </li> </ol> <p><strong>License: </strong><a href="https://creativecommons.org/licenses/by/4.0/legalcode">Creative Commons Attribution 4.0 International</a> <a href="https://creativecommons.org/licenses/by/4.0/legalcode"><img src="https://i.creativecommons.org/l/by/3.0/88x31.png"> </a></p>

<p>Publications based on this data collection should acknowledge this source by means of bibliographic citation.</p>

<p>This data is licensed under the <a href="https://creativecommons.org/licenses/by/4.0/legalcode">Creative Commons Attribution 4.0 International</a> <a href="https://creativecommons.org/licenses/by/4.0/legalcode"><img src="https://i.creativecommons.org/l/by/3.0/88x31.png"> </a> </p>

For access to data and more detailed information beyond the metadata and documentation provided, please send a signed data request form to [<a href="mailto:dgc@kemri-wellcome.org">dgc@kemri-wellcome.org</a> ]. <strong> <a href="https://kemri-wellcome.org/zp-content/uploads/2021/02/KWTRP_Dataverse_Data_Request_Form_2019.docx">Click to download Data Request Form</a></strong>

Kapulu, Melissa C.; Otieno, Edward; Bejon, Philip, 2022, "Data for: Controlled Human Malaria Infection in Semi-Immune Kenyan Adults (CHMI-SIKA)", https://doi.org/10.7910/DVN/YPVZFV, Harvard Dataverse, V2

https://doi.org/10.7910/DVN/YPVZFV

Kapulu, Melissa C.; Otieno, Edward; Bejon, Philip, 2022, "Data for: Controlled Human Malaria Infection in Semi-Immune Kenyan Adults (CHMI-SIKA)", https://doi.org/10.7910/DVN/YPVZFV, Harvard Dataverse, V2

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AKinyua_Plasmodium_alciparum_variant_Codebook.pdf

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Contains variable descriptions

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breadth_inhibition_domains.csv

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Cumulative anti-VSA antibody levels (measured against 6 P. falciparum isolates), antibody levels to two PfEMP! domains (DC4, DC13) and percentage binding inhibition (ability of an individuals plasma sample to inhibit the interaction between PfEMP1 domains and ICAM1)

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CHMI_epi_data.csv

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A description of the CHMI outcome after the challenge

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correlation matrix_Sup_fig2.R

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isolates_boxplots_figure1.R

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Multivariate_analysis_Table1_2.R

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Survival_analysis_figure2.R

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Test_isolates.csv

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Anti-VSA antibody levels measured against six P. falciparum isolates

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Univariate_cox_regression-Table1_2.R

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