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Part 1: Document Description
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Citation |
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Title: |
Replication Data for: Blood Pressure and Arterial Stiffness in Kenyan Adolescents With α+Thalassemia |
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Identification Number: |
doi:10.7910/DVN/0GTMAN |
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Distributor: |
Harvard Dataverse |
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Date of Distribution: |
2018-04-23 |
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Version: |
1 |
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Bibliographic Citation: |
Etyang, A.O., 2018, "Replication Data for: Blood Pressure and Arterial Stiffness in Kenyan Adolescents With α+Thalassemia", https://doi.org/10.7910/DVN/0GTMAN, Harvard Dataverse, V1, UNF:6:/3s3KxvPr1NGrcI7F55NcA== [fileUNF] |
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Citation |
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Title: |
Replication Data for: Blood Pressure and Arterial Stiffness in Kenyan Adolescents With α+Thalassemia |
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Identification Number: |
doi:10.7910/DVN/0GTMAN |
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Authoring Entity: |
Etyang, A.O. (KEMRI-Wellcome Trust Research Programme, Kilifi Kenya) |
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Distributor: |
Harvard Dataverse |
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Access Authority: |
Etyang, A.O. |
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Depositor: |
Etyang, A.O. |
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Date of Deposit: |
2018-02-19 |
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Holdings Information: |
https://doi.org/10.7910/DVN/0GTMAN |
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Study Scope |
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Keywords: |
Medicine, Health and Life Sciences |
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Abstract: |
<p>Background recent studies have discovered that a_globin is expressed in blood vessel walls where it plays a role in regulating vascular tone. We tested the hypothesis that blood pressure (BP) might differ between normal individuals and those with alpha thalassemia, in whom the production of alpha globin is reduced.</p> <p>The related study - Shinikizo la Damu 2 (ShinDa2) - was conducted in Nairobi, Kenya, among 938 adolescents aged 11 to 17 years. Twenty‐four‐hour ambulatory BP monitoring and arterial stiffness measurements were performed using an arteriograph device. We genotyped for α+thalassemia by polymerase chain reaction. Complete data for analysis were available for 623 subjects; 223 (36%) were heterozygous (−α/αα) and 47 (8%) were homozygous (−α/−α) for α+thalassemia whereas the remaining 353 (55%) were normal (αα/αα). Mean 24‐hour systolic BP ±SD was 118±12 mm Hg in αα/αα, 117±11 mm Hg in −α/αα, and 118±11 mm Hg in −α/−α subjects, respectively. Mean 24‐hour diastolic BP ±SD in these groups was 64±8, 63±7, and 65±8 mm Hg, respectively. Mean pulse wave velocity (PWV)±SD was 7±0.8, 7±0.8, and 7±0.7 ms−1, respectively. No differences were observed in PWV and any of the 24‐hour ambulatory BP monitoring‐derived measures between those with and without α+thalassemia.</p> |
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Methodology and Processing |
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Sources Statement |
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Data Access |
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Extent of Collection: |
Two (2) datasets, analysis code (STATA do files), variable codebook and readme file |
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Citation Requirement: |
Publications based on this data collection should acknowledge this source by means of bibliographic citation. To ensure that such source attributions are captured for bibliographic utilities, citations must appear in footnotes or in the reference section of publications. The bibliographic citation for this data collection is: "Etyang, A.O., 2018, "Replication Data for: Blood Pressure and Arterial Stiffness in Kenyan Adolescents With α+Thalassemia", doi:10.7910/DVN/0GTMAN, Harvard Dataverse, V1" |
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Notes: |
This data is made available under the Creative Commons Attribution 4.0 International (CC BY 4.0) - https://creativecommons.org/licenses/by/4.0/legalcode. Publications based on these data should acknowledge this source by means of bibliographic citations. For more information on these data, please contact the authors: Etyang, AO (AEtyang@kemri-wellcome.org) OR the data governance office via this email address: dgc@kemri-wellcome.org |
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For access to restricted files and more detailed information beyond the metadata/documentation provided, please contact the Data Governance Committee via this email address- dgc@kemri-wellcome.org |
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Other Study Description Materials |
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Related Publications |
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Citation |
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Title: |
Etyang, A.O., Khayeka‐Wandabwa, C., Kapesa, S., Muthumbi, E., Odipo, E., Wamukoya, M., Ngomi, N., Haregu, T., Kyobutungi, C., Tendwa, M. and Makale, J., 2017. Blood Pressure and Arterial Stiffness in Kenyan Adolescents With α+ Thalassemia. Journal of the American Heart Association, 6(4), p.e005613. |
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Identification Number: |
10.1161/JAHA.117.005613 |
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Bibliographic Citation: |
Etyang, A.O., Khayeka‐Wandabwa, C., Kapesa, S., Muthumbi, E., Odipo, E., Wamukoya, M., Ngomi, N., Haregu, T., Kyobutungi, C., Tendwa, M. and Makale, J., 2017. Blood Pressure and Arterial Stiffness in Kenyan Adolescents With α+ Thalassemia. Journal of the American Heart Association, 6(4), p.e005613. |
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File Description--f3127060 |
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File: Etyang_et_al_Thalassemia_BP_AnalysisNbi.tab |
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Notes: |
UNF:6:lpOQMyPLkKoqlu2xD+y8GA== |
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STATA dataset |
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File Description--f3127061 |
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File: Etyang_et_al_Thalassemia_BP_Graph.tab |
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Notes: |
UNF:6:iKjDYB3w4y5sfs9m/tyB+A== |
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STATA dataset |
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Label: |
Etyang_et_al_Thalassemia_BP_Analysis.do |
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Text: |
STATA do file |
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Notes: |
application/x-stata-syntax |
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Label: |
Etyang_et_al_thalassemia_BP_Codebook.pdf |
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Text: |
Data Dictionary/ Variable Codebook |
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Notes: |
application/pdf |
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Label: |
Etyang_et_al_Thalassemia_BP_Graph.do |
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Text: |
STATA do file |
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Notes: |
application/x-stata-syntax |
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Label: |
Etyang_et_al_Thalassemia_BP_Readme.txt |
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Text: |
Readme File |
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Notes: |
text/plain |