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Part 1: Document Description
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Citation |
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Title: |
Replication Data for: Maintenance of high temporal Plasmodium falciparum genetic diversity in Kilifi, Kenya, despite a reduction in community malaria transmission from 2007 to 2018 |
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Identification Number: |
doi:10.7910/DVN/3UE1NB |
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Distributor: |
Harvard Dataverse |
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Date of Distribution: |
2022-03-24 |
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Version: |
2 |
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Bibliographic Citation: |
Kimenyi, Kelvin M.; Wamae, Kevin; Ngoi, Joyce M.; deLaurent, Zaydah R.; Ndwiga, Leonard; Osoti, Victor; Obiero, George; Abdi, Abdirahman I.; Bejon, Philip; Ochola-Oyier, Lynette Isabella, 2022, "Replication Data for: Maintenance of high temporal Plasmodium falciparum genetic diversity in Kilifi, Kenya, despite a reduction in community malaria transmission from 2007 to 2018", https://doi.org/10.7910/DVN/3UE1NB, Harvard Dataverse, V2, UNF:6:HlgflV84siAZ2Zr5sCm0lQ== [fileUNF] |
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Citation |
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Title: |
Replication Data for: Maintenance of high temporal Plasmodium falciparum genetic diversity in Kilifi, Kenya, despite a reduction in community malaria transmission from 2007 to 2018 |
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Identification Number: |
doi:10.7910/DVN/3UE1NB |
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Authoring Entity: |
Kimenyi, Kelvin M. (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya; Department of Biochemistry, University of Nairobi) |
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Wamae, Kevin (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya) |
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Ngoi, Joyce M. (West Africa Centre for Cell Biology and Infectious Pathogen, Accra, Ghana) |
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deLaurent, Zaydah R. (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya) |
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Ndwiga, Leonard (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya) |
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Osoti, Victor (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya) |
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Obiero, George (Department of Biochemistry, University of Nairobi) |
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Abdi, Abdirahman I. (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya) |
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Bejon, Philip (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya) |
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Ochola-Oyier, Lynette Isabella (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya) |
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Distributor: |
Harvard Dataverse |
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Access Authority: |
Kimenyi, Kelvin M. |
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Access Authority: |
The Data Governance Committee |
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Depositor: |
Kimenyi, Kelvin M. |
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Date of Deposit: |
2022-03-24 |
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Holdings Information: |
https://doi.org/10.7910/DVN/3UE1NB |
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Study Scope |
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Keywords: |
Medicine, Health and Life Sciences, Medicine, Health and Life Sciences, malaria, P. falciparum, msp2, genetic diversity, complexity of infections, Kenya |
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Abstract: |
<p>This is a replication dataset for the submitted manuscript title: "<a href="">Maintenance of high temporal Plasmodium falciparum genetic diversity in Kilifi, Kenya, despite a reduction in community malaria transmission from 2007 to 2018</a>."</p> <p>The project describes the genetic diversity and complexity of asymptomatic Plasmodium falciparum infections in Kilifi from 2007 - 2018. It also describes the genetic diversity and COI of follow-up febrile malaria infections and reports that asymptomatic infections have a high genetic diversity despite a reduction in malaria transmission in the region. Blood samples and corresponding metadata were collected from children aged (0-15) years with asymptomatic and follow-up febrile malaria episodes. The samples were genotyped using capillary electrophresis based on the merozoite surface protein 2 (msp2) gene. Metadata from each participant included age and parasitemia (based on microscopy results). The genotypes data include the fragment sizes (labelled as genotypes) corresponding to each successfully identified clone based on capillary electrophoresis.The number of genotypes per participants constitute the complexity of infections otherwise known as COI. </p> |
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Notes: |
<p><strong>Data Access: </strong>Restricted</p> <p>Access to these data requires submission of a formal request for consideration by our Data Governance Committee. </p> <strong>How to request</strong> <ol> <li>Download and complete the <a href="https://kemri-wellcome.org/zp-content/uploads/2021/02/KWTRP_Dataverse_Data_Request_Form_2019.docx"><strong>data request form</strong></a></li> <li> Email completed data request form to the Data Governance Committee at <a href="mailto:dgc@kemri-wellcome.org?cc=lmwango@kemri-wellcome.org?Subject=Data%20Access%20Request"><strong>dgc@kemri-wellcome.org</strong></a> </li> </ol> <p><strong>License: </strong><a href="https://creativecommons.org/licenses/by/4.0/legalcode">Creative Commons Attribution 4.0 International</a> <a href="https://creativecommons.org/licenses/by/4.0/legalcode"><img src="https://i.creativecommons.org/l/by/3.0/88x31.png"> </a></p> |
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Methodology and Processing |
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Sources Statement |
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Data Access |
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Citation Requirement: |
<p>Publications based on this data collection should acknowledge this source by means of bibliographic citation.</p> |
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Notes: |
<p>This data is licensed under the <a href="https://creativecommons.org/licenses/by/4.0/legalcode">Creative Commons Attribution 4.0 International</a> <a href="https://creativecommons.org/licenses/by/4.0/legalcode"><img src="https://i.creativecommons.org/l/by/3.0/88x31.png"> </a> </p> |
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For access to data and more detailed information beyond the metadata and documentation provided, please send a signed data request form to [<a href="mailto:dgc@kemri-wellcome.org">dgc@kemri-wellcome.org</a> ]. <strong> <a href="https://kemri-wellcome.org/zp-content/uploads/2021/02/KWTRP_Dataverse_Data_Request_Form_2019.docx">Click to download Data Request Form</a></strong> |
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Other Study Description Materials |
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File Description--f6153084 |
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File: Asymptomatic_samples_dataset.tab |
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Notes: |
UNF:6:dh3oj9GR8iAhDCEqiEPJDg== |
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File Description--f6153081 |
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File: febrile_samples_dataset.tab |
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Notes: |
UNF:6:VKMz0dp6g/uMwvltJ8iaWQ== |
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File Description--f6153083 |
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File: Genotypes_data.tab |
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Notes: |
UNF:6:S7ngxwSqm7t0PNkmqnD17w== |
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File Description--f6153085 |
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File: Junju_cohort_cross-sectional_bleed.tab |
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Notes: |
UNF:6:+HmxvJSbh2/2Y/tRgBqCiA== |
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File Description--f6153080 |
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File: Paired_data-asymptomatic-samples.tab |
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Notes: |
UNF:6:yrJR1WThaXafKXhDDqn6Iw== |
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File Description--f6153082 |
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File: Paired_data-febrile-samples.tab |
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Notes: |
UNF:6:ZAcfWIBX6/0BzHyUCekYlw== |
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Label: |
Kimenyi_etal_MSP2_Codebook.pdf |
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Text: |
Contains variable descriptions and value labels |
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Notes: |
application/pdf |
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Label: |
Kimenyi_etal_MSP2_Readme.txt |
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Notes: |
text/plain |
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Label: |
R.markdown_msp2_3.Rmd |
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Notes: |
application/octet-stream |