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Part 1: Document Description
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Citation |
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Title: |
Replication Data for: Non-O ABO blood group genotypes differ in their associations with Plasmodium falciparum rosetting and severe malaria |
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Identification Number: |
doi:10.7910/DVN/A5KILM |
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Distributor: |
Harvard Dataverse |
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Date of Distribution: |
2023-06-02 |
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Version: |
1 |
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Bibliographic Citation: |
Opi, Herbert; Ndila, Carolyne M.; Uyoga, Sophie; Macharia, Alex W.; Fennell,Clare; Ochola, Lucy B.; Nyutu,Gideon; Siddondo,Bethsheba R.; Ojal, John; Shebe, Mohammed; Awuondo, Kennedy O.; Mturi, Neema; Peshu, Norbert; Tsofa, Benjamin; Band, Gavin; Maitland, Kathryn; Kwiatkowski, Dominic P.; Rockett, Kirk A.; Williams, Thomas N.; Rowe, J. Alexandra, 2023, "Replication Data for: Non-O ABO blood group genotypes differ in their associations with Plasmodium falciparum rosetting and severe malaria", https://doi.org/10.7910/DVN/A5KILM, Harvard Dataverse, V1 |
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Citation |
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Title: |
Replication Data for: Non-O ABO blood group genotypes differ in their associations with Plasmodium falciparum rosetting and severe malaria |
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Identification Number: |
doi:10.7910/DVN/A5KILM |
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Authoring Entity: |
Opi, Herbert (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya; Centre for Immunity, Infection and Evolution, Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, UK) |
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Ndila, Carolyne M. (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya) |
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Uyoga, Sophie (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya) |
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Macharia, Alex W. (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya) |
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Fennell,Clare (Centre for Immunity, Infection and Evolution, Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, UK) |
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Ochola, Lucy B. (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya) |
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Nyutu,Gideon (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya) |
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Siddondo,Bethsheba R. (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya) |
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Ojal, John (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya) |
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Shebe, Mohammed (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya) |
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Awuondo, Kennedy O. (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya) |
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Mturi, Neema (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya) |
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Peshu, Norbert (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya) |
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Tsofa, Benjamin (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya) |
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Band, Gavin (Wellcome Centre for Human Genetics, Oxford, UK) |
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Maitland, Kathryn (Kenya Medical Research Institute-Wellcome Trust Research Programme, Kilifi, Kenya; Institute for Global Health Innovation, Department of Surgery and Cancer, Imperial College, London, UK) |
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Kwiatkowski, Dominic P. (Wellcome Centre for Human Genetics, Oxford, UK) |
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Rockett, Kirk A. (Wellcome Centre for Human Genetics, Oxford, UK) |
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Williams, Thomas N. (Kenya Medical Research Institute-Wellcome Trust Research Programme, Kilifi, Kenya; Institute for Global Health Innovation, Department of Surgery and Cancer, Imperial College, London, UK) |
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Rowe, J. Alexandra (Centre for Immunity, Infection and Evolution, Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, UK) |
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Distributor: |
Harvard Dataverse |
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Access Authority: |
Opi, Herbert |
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Access Authority: |
The Data Governance Committee |
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Depositor: |
Opi, Herbert |
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Date of Deposit: |
2023-06-02 |
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Holdings Information: |
https://doi.org/10.7910/DVN/A5KILM |
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Study Scope |
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Keywords: |
Medicine, Health and Life Sciences, ABO blood group, ABO genotype, Severe malaria, Rosette, Cytoadhesion, Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) |
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Abstract: |
<p>We present here the replication dataset used to generate results for the manuscript titled "<a href="">Non-O ABO blood group genotypes differ in their associations with Plasmodium falciparum rosetting and severe malaria</a>".</p> <p>The dataset included here comprise of clinical, epidemiological and multiple host genotype (including ABO blood group) data from a cases control study (n = 1403 cases and n = 3929 controls) and longitudinal cohort study (n = 242) of children recruited as part of the Kilifi Health and Demographic Surveillance System (KHDSS) used to look at associations between ABO genotypes and severe malaria or uncomplicated malaria/asymptomatic infection respectively. Also included are data from in vitro experiments on a range of putative P. falciparum virulence phenotypes including P. falciparum rosetting and endothelial cell cytoadhesion generated using human red blood cell samples collected during routine cross-section surveys as part of the Kilifi longitudinal cohort study to used to look at variations in these parasite phenotypes by ABO genotype. </p> |
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Methodology and Processing |
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Sources Statement |
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Data Access |
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Other Study Description Materials |
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