Replication Data for: Vectorial capacity and TEP1 genotypes of Anopheles gambiae sensu lato mosquitoes on the Kenyan coast (doi:10.7910/DVN/CKMX29)

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Part 1: Document Description
Part 2: Study Description
Part 3: Data Files Description
Part 4: Variable Description
Part 5: Other Study-Related Materials
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Replication Data for: Vectorial capacity and TEP1 genotypes of Anopheles gambiae sensu lato mosquitoes on the Kenyan coast

doi:10.7910/DVN/CKMX29

Harvard Dataverse

2022-01-07

2

Bartilol, Brian; Omuoyo, Donwilliams; Karisa, Jonathan; Ominde, Kelly; Mbogo, Charles; Mwangangi, Joseph; Maia, Marta; Rono, Martin K., 2022, "Replication Data for: Vectorial capacity and TEP1 genotypes of Anopheles gambiae sensu lato mosquitoes on the Kenyan coast", https://doi.org/10.7910/DVN/CKMX29, Harvard Dataverse, V2, UNF:6:OFR60YvUKp4Y4nfJnVB3Ag== [fileUNF]

Replication Data for: Vectorial capacity and TEP1 genotypes of Anopheles gambiae sensu lato mosquitoes on the Kenyan coast

doi:10.7910/DVN/CKMX29

Bartilol, Brian (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya; Pwani University Bioscience Research Centre (PUBReC), Pwani University, Kilifi, Kenya)

Omuoyo, Donwilliams (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya)

Karisa, Jonathan (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya)

Ominde, Kelly (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya)

Mbogo, Charles (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya)

Mwangangi, Joseph (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya)

Maia, Marta (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Old Road Campus Roosevelt Drive, Oxford, OX3 7FZ, UK)

Rono, Martin K. (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya; Pwani University Bioscience Research Centre (PUBReC), Pwani University, Kilifi, Kenya)

Harvard Dataverse

Rono, Martin K.

Bartilol, Brian

The Data Governance Committee

Bartilol, Brian

2022-01-06

https://doi.org/10.7910/DVN/CKMX29

Medicine, Health and Life Sciences, Anopheles merus, Thioester-containing protein 1, allele, Kenya

<p>This is a replication dataset for "<a href="">Vectorial capacity and TEP1 genotypes of Anopheles gambiae sensu lato mosquitoes on the Kenyan coast</a>." <p>Malaria remains one of the most important infectious diseases in Sub-Saharan Africa, responsible for approximately 228 million cases and 602,000 deaths in 2020. Malaria transmission is mainly driven by mosquitoes of the Anopheles gambiae and more recently Anopheles funestus complex. The gains made in malaria control are threatened by insecticide resistance and behavioural plasticity among these vectors. This therefore calls for the development of more effective novel interventions, e.g. gene drive systems that can lead to population replacement of infection-susceptible mosquitoes with mosquitoes that are resistant to Plasmodium spp. infection. One such gene that can be utilised is Thioester-containing protein 1 gene which mediates the killing of Plasmodium falciparum in the mosquito midgut. Mosquitoes were collected using CDC light traps both indoors and outdoors from 20 houses in Garithe village, along the Kenyan coast. The mosquitoes were dissected, and the parts used to determine its species, source of blood-meal and sporozoite status. The data was analysed and visualised using the R (v 4.0.1) and STATA (v 17.0). </p>

Open Access

<p><strong>Data Access: </strong>Open</p> <p><strong>License: </strong><a href="https://creativecommons.org/licenses/by/4.0/legalcode">Creative Commons Attribution 4.0 International</a> <a href="https://creativecommons.org/licenses/by/4.0/legalcode"><img src="https://i.creativecommons.org/l/by/3.0/88x31.png"> </a></p>

<p>Publications based on this data collection should acknowledge this source by means of bibliographic citation.</p>

<p>This data is licensed under the <a href="https://creativecommons.org/licenses/by/4.0/legalcode">Creative Commons Attribution 4.0 International</a> <a href="https://creativecommons.org/licenses/by/4.0/legalcode"><img src="https://i.creativecommons.org/l/by/3.0/88x31.png"> </a> </p>

For more information on these data, please contact the author(s) OR the data governance office via this email address: dgc@kemri-wellcome.org

Manuscript in Preparation

• Number of cases: 580

• No. of variables per record: 11

• Type of File: text/tab-separated-values

UNF:6:8d6BLGMXXmZKl3f4Gzor/A==

• Number of cases: 20

• No. of variables per record: 3

• Type of File: text/tab-separated-values

UNF:6:73pZKzeoMEKAfz1S9wi1Rw==

• Number of cases: 100

• No. of variables per record: 27

• Type of File: text/tab-separated-values

UNF:6:bNJQHvKtjNcXLFJgUIjE0g==

• mos_id - mos_id
• sporozoite_pcr - sporozoite_pcr
• location - location
• date_of_collection - date_of_collection
• site - site
• mosquito.genus - mosquito.genus
• status - status
• species - species
• BM_ELISA - BM_ELISA
• house - house
• allele - allele
• house - house
• latitude - latitude
• longitude - longitude
• Date - Date
• location - location
• latitude - latitude
• longitude - longitude
• Hse_no - Hse_no
• Ang_uf - Ang_uf
• Ang_bf - Ang_bf
• Ang_hg - Ang_hg
• Ang_g - Ang_g
• Anf_uf - Anf_uf
• Anf_bf - Anf_bf
• Anf_hg - Anf_hg
• Anf_g - Anf_g
• Ano_uf - Ano_uf
• Ano_bf - Ano_bf
• Ano_hg - Ano_hg
• Ano_g - Ano_g
• Cx_uf - Cx_uf
• Cx_bf - Cx_bf
• Cx_hg - Cx_hg
• Cx_g - Cx_g
• Remarks - Remarks
• Anopheles_gambiae - Anopheles_gambiae
• Anopheles_funestus - Anopheles_funestus
• other_Anopheles - other_Anopheles
• Culex_spp - Culex_spp
• site - site

f6697815 Location:

Variable Format: character

Notes: UNF:6:LU0UAvlAqpzloQ7aqTot2A==

f6697815 Location:

Variable Format: character

Notes: UNF:6:9xGw6io216FfckcOHfVrpQ==

f6697815 Location:

Variable Format: character

Notes: UNF:6:ZlEsIpejLBHJO/DT5fkz7Q==

f6697815 Location:

Variable Format: character

Notes: UNF:6:Rsv/nxK9BUb/L1uK+vHO2g==

f6697815 Location:

Variable Format: character

Notes: UNF:6:ayKdzCVdAEBhQEVsWcS0Iw==

f6697815 Location:

Variable Format: character

Notes: UNF:6:HzKEDIsgm5FwTroOEwNMaw==

f6697815 Location:

Variable Format: character

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f6697815 Location:

Variable Format: character

Notes: UNF:6:I1qFj6DjOOk1j1uuM9Or4A==

f6697815 Location:

Variable Format: character

Notes: UNF:6:/JqLzbXnJ1lu6qbseS3vuA==

f6697815 Location:

Summary Statistics: Max. 20.0; Valid 580.0; StDev 4.3249642018758365; Mean 14.432758620689652; Min. 1.0;

Variable Format: numeric

Notes: UNF:6:DxlpX8Y6lvXW6UdNzlyXNQ==

f6697815 Location:

Variable Format: character

Notes: UNF:6:qi5Lm7zSYGhqDTxgxl+AEg==

f6697814 Location:

Summary Statistics: Min. 1.0; Max. 20.0; Mean 10.5; StDev 5.916079783099616; Valid 20.0

Variable Format: numeric

Notes: UNF:6:/FIOZM/29oC3TK/IE52m2A==

f6697814 Location:

Summary Statistics: Min. -3.02866; Valid 20.0; Max. -3.02115; Mean -3.0249382000000002; StDev 0.0028805539598815875

Variable Format: numeric

Notes: UNF:6:wg4jd+OEa5iCoy4Ii7giFg==

f6697814 Location:

Summary Statistics: StDev 0.0017000007306499732; Max. 40.17183; Mean 40.1691862; Min. 40.167084; Valid 20.0;

Variable Format: numeric

Notes: UNF:6:Kn8/9VYstd0Ozzvd80RXyg==

f6697816 Location:

Variable Format: character

Notes: UNF:6:48LDErq1uuDWuyAiHmZkow==

f6697816 Location:

Variable Format: character

Notes: UNF:6:qT+OAmOxGjG//l0DzzTWqw==

f6697816 Location:

Summary Statistics: Mean -3.02440976; Max. -3.02115; Valid 100.0; Min. -3.02866; StDev 0.002787402647192503

Variable Format: numeric

Notes: UNF:6:Qv026hMFt7rC7k0GQstHYA==

f6697816 Location:

Summary Statistics: StDev 0.0016711110410487487; Valid 100.0; Mean 40.16947136; Min. 40.167084; Max. 40.17183;

Variable Format: numeric

Notes: UNF:6:1BGIHcaDm6aiJXlgQHiITQ==

f6697816 Location:

Summary Statistics: Mean 11.5; Min. 1.0; Valid 100.0; Max. 20.0; StDev 5.7075176369204135

Variable Format: numeric

Notes: UNF:6:FC+JRNXz/aktiagfwNa9Yg==

f6697816 Location:

Summary Statistics: Valid 100.0; Mean 39.160000000000025; Min. 0.0; StDev 150.37903088294235; Max. 1280.0;

Variable Format: numeric

Notes: UNF:6:iR/BMAotoPnTCV0o72XB9A==

f6697816 Location:

Summary Statistics: Max. 28.0; Min. 0.0; Mean 0.9000000000000009; Valid 100.0; StDev 3.696845502136472

Variable Format: numeric

Notes: UNF:6:5IJ9yiLsT7CKSlzXCUPBDg==

f6697816 Location:

Summary Statistics: Mean 0.0; StDev 0.0; Max. 0.0; Valid 100.0; Min. 0.0;

Variable Format: numeric

Notes: UNF:6:PStPdlq1HipLncxsCR0xbw==

f6697816 Location:

Summary Statistics: Mean 0.19999999999999996; Min. 0.0; Max. 3.0; Valid 100.0; StDev 0.5124707431905376;

Variable Format: numeric

Notes: UNF:6:szY5Dah96bMDx0v9IkadIw==

f6697816 Location:

Summary Statistics: Mean 0.6100000000000003; Max. 6.0; Min. 0.0; Valid 100.0; StDev 1.3990978334179307

Variable Format: numeric

Notes: UNF:6:sapz8Kn17SX0WrnuUx4fgw==

f6697816 Location:

Summary Statistics: StDev 0.2611164839335472; Max. 2.0; Mean 0.04999999999999999; Valid 100.0; Min. 0.0;

Variable Format: numeric

Notes: UNF:6:f8kCRUJVUsKZjjKjZQDsZA==

f6697816 Location:

Summary Statistics: Mean 0.0; Min. 0.0; Max. 0.0; StDev 0.0; Valid 100.0

Variable Format: numeric

Notes: UNF:6:PStPdlq1HipLncxsCR0xbw==

f6697816 Location:

Summary Statistics: Max. 1.0; Mean 0.009999999999999993; StDev 0.09999999999999995; Min. 0.0; Valid 100.0;

Variable Format: numeric

Notes: UNF:6:L88qJuf3LbKEugeFDUpqcQ==

f6697816 Location:

Summary Statistics: Mean 0.7; Max. 20.0; Min. 0.0; Valid 100.0; StDev 2.4964621431784684

Variable Format: numeric

Notes: UNF:6:XyTdZeR+6kZ2nBYwSvF6tw==

f6697816 Location:

Summary Statistics: StDev 0.3554766326548572; Max. 2.0; Valid 100.0; Mean 0.06999999999999998; Min. 0.0;

Variable Format: numeric

Notes: UNF:6:C8tRrXnfvL+lTTdjBgTEkQ==

f6697816 Location:

Summary Statistics: Min. 0.0; Max. 0.0; Valid 100.0; StDev 0.0; Mean 0.0

Variable Format: numeric

Notes: UNF:6:PStPdlq1HipLncxsCR0xbw==

f6697816 Location:

Summary Statistics: Valid 100.0; Min. 0.0; Max. 1.0; Mean 0.009999999999999995; StDev 0.09999999999999996;

Variable Format: numeric

Notes: UNF:6:cMlVvvI5QgziQV6TjpANHQ==

f6697816 Location:

Summary Statistics: Valid 100.0; Mean 141.79999999999993; StDev 439.1871509224211; Max. 3200.0; Min. 0.0;

Variable Format: numeric

Notes: UNF:6:D87Zu3k2mrp7seizk2oqPw==

f6697816 Location:

Summary Statistics: StDev 9.880145379865255; Max. 65.0; Valid 100.0; Mean 3.8299999999999996; Min. 0.0

Variable Format: numeric

Notes: UNF:6:NKcNpppcWZpVa0MJhnqpGQ==

f6697816 Location:

Summary Statistics: Min. 0.0; Valid 100.0; StDev 0.0; Max. 0.0; Mean 0.0

Variable Format: numeric

Notes: UNF:6:PStPdlq1HipLncxsCR0xbw==

f6697816 Location:

Summary Statistics: Min. 0.0; Max. 30.0; StDev 3.6663222978782417; Valid 100.0; Mean 0.75

Variable Format: numeric

Notes: UNF:6:mGY7jqFnHDNxwjyI3oMn9Q==

f6697816 Location:

Variable Format: character

Notes: UNF:6:xlHW7WD1uw7Cj8YpKd2diQ==

f6697816 Location:

Summary Statistics: Max. 1308.0; Min. 0.0; Mean 40.25999999999993; StDev 153.5260725397968; Valid 100.0

Variable Format: numeric

Notes: UNF:6:LQY2l29KsA8d4bQNeE1BOQ==

f6697816 Location:

Summary Statistics: Max. 7.0; Mean 0.6699999999999995; Min. 0.0; StDev 1.5508550916031825; Valid 100.0;

Variable Format: numeric

Notes: UNF:6:0SRB3HDwtsInC0qgYsIqOQ==

f6697816 Location:

Summary Statistics: StDev 2.6688627321067453; Mean 0.7799999999999994; Min. 0.0; Max. 22.0; Valid 100.0

Variable Format: numeric

Notes: UNF:6:1E1sLfLV1pKLRRwiXUBYmQ==

f6697816 Location:

Summary Statistics: Min. 0.0; Mean 146.31; StDev 445.3911842074301; Valid 100.0; Max. 3230.0;

Variable Format: numeric

Notes: UNF:6:mrTTSxKFwzxLeih71U0svA==

f6697816 Location:

Variable Format: character

Notes: UNF:6:a9kSV+MQE82UBP22WcdkxA==

Label:

Bartilol_Vectorial capacity and TEP1 genotypes of Anopheles gambiae_Codebook_V2.pdf

Text:

Contains variable descriptions and value labels

application/pdf

Label:

Bartilol_Vectorial capacity and TEP1 genotypes of Anopheles gambiae_readme.txt

text/plain

Label:

Vectorial capacity and TEP1 genotypes of Anopheles gambiae.R

Text:

contains the R script that was used for analysis

type/x-r-syntax