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Part 1: Document Description
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Citation |
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Title: |
Replication Data for: Systemic biological mechanisms underpin poor post-discharge growth among severely wasted children with HIV |
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Identification Number: |
doi:10.7910/DVN/D8HZLJ |
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Distributor: |
Harvard Dataverse |
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Date of Distribution: |
2024-06-05 |
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Version: |
2 |
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Bibliographic Citation: |
Mudibo, Evans O.; Bogaert, Jasper; Tigoi, Caroline; Ngari, Moses M.; Singa, Benson O.; Lancioni, Christina L.; Diallo, Abdoulaye Hama; Mbale, Emmie; Thitiri, Johnstone; Timbwa, Molline; Omer, Elisha; Ngao, Narshion; Musyimi,Robert; Kahindi, Eunice; Mupere, Ezekiel; Mukisa,John; Bamouni, Roseline Maìˆmouna; Bandsma, Robert H.J.; Kelly, Paul; Prendergast, Andrew J.; McGrath, Christine J.; Tickell, Kirkby D.; Walson, Judd L.; Berkley, James A.; Njunge, James M.; Gonzales, Gerard Bryan., 2024, "Replication Data for: Systemic biological mechanisms underpin poor post-discharge growth among severely wasted children with HIV", https://doi.org/10.7910/DVN/D8HZLJ, Harvard Dataverse, V2 |
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Citation |
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Title: |
Replication Data for: Systemic biological mechanisms underpin poor post-discharge growth among severely wasted children with HIV |
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Identification Number: |
doi:10.7910/DVN/D8HZLJ |
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Authoring Entity: |
Mudibo, Evans O. (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya) |
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Bogaert, Jasper (epartment of Data Analysis, Faculty of Psychology and Education Sciences, Ghent University) |
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Tigoi, Caroline (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya) |
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Ngari, Moses M. (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya) |
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Singa, Benson O. (Center for Clinical Research, Kenya Medical Research Institute, Nairobi, Kenya) |
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Lancioni, Christina L. (Department of Pediatrics, Oregon Health and Science University, Portland, OR, USA) |
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Diallo, Abdoulaye Hama (Department of Public Health, University Joseph Ki-Zerbo, Ouagadougou, Burkina Faso) |
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Mbale, Emmie (Department of Paediatrics and Child Health, Kamuzu University of Health Sciences, Blantyre, Malawi) |
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Thitiri, Johnstone (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya) |
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Timbwa, Molline (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya) |
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Omer, Elisha (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya) |
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Ngao, Narshion (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya) |
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Musyimi,Robert (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya) |
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Kahindi, Eunice (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya) |
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Mupere, Ezekiel (Department of Paediatrics and Child Health, Makerere University College of Health Sciences, Kampala, Uganda) |
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Mukisa,John (Department of Immunology and Department of Molecular Biology Makerere University College of Health Sciences, Kampala, Uganda) |
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Bamouni, Roseline Maìˆmouna (Department of Pediatrics and Child Health, Aga Khan University, Karachi, Pakistan) |
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Bandsma, Robert H.J. (Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, ON, Canada) |
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Kelly, Paul (Tropical Gastroenterology and Nutrition Group, Department of Medicine, University of Zambia School of Medicine, Lusaka, Zambia) |
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Prendergast, Andrew J. (Zvitambo Institute for Maternal and Child Health Research, 16 Lauchlan Ave, Meyrick Park, Harare, Zimbabwe) |
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McGrath, Christine J. (Department of Global Health, University of Washington, Seattle, USA) |
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Tickell, Kirkby D. (Department of Global Health, University of Washington, Seattle, USA) |
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Walson, Judd L. (Departments of International Health, Pediatrics and Medicine, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA) |
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Berkley, James A. (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya) |
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Njunge, James M. (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya) |
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Gonzales, Gerard Bryan. (Department of Public Health and Primary Care, Faculty of Medicine and Health Sciences, Ghent University) |
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Distributor: |
Harvard Dataverse |
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Access Authority: |
Mudibo, Evans O. |
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Access Authority: |
Njunge, James M. |
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Access Authority: |
The Data Governance Committee |
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Depositor: |
Mudibo, Evans O. |
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Date of Deposit: |
2024-06-05 |
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Holdings Information: |
https://doi.org/10.7910/DVN/D8HZLJ |
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Study Scope |
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Keywords: |
Medicine, Health and Life Sciences, HIV, Severe malnutrition, Protein modules, Biological processes, Structural equation modelling, Post-discharge growth |
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Abstract: |
<p>This is a replication dataset for the manuscript titled: "<strong><i>Systemic biological mechanisms underpin poor post-discharge growth among severely wasted children with HIV</i></strong>."</p> <p>In sub-Saharan Africa, a proportion of children hospitalised with severe malnutrition (SM) also have HIV infection (HIV-SM). Children with HIV-SM have poorer clinical outcomes than children with SM alone. They face high mortality both during and after hospitalisation, have impaired nutritional recovery post-hospitalisation and have increased relapse recovery. Despite this elevated risks biological mechanisms underlying the risk remain unclear. This study is nested with the CHAIN cohort sites in Kenya, Uganda, Malawi and Burkina Faso. The current study aimed to understand how HIV influences post-discharge growth among children with HIV-SM in sub-Saharan Africa. In the current study proteins from plasma collected from children at hospital discharge were quantified using SomaScan assay. Over 7300 proteins were quantified. The analysis also included anthropometric measurements e.g., mid-upper arm circumference, weight-for-age, weight-for-height and height-for-age scores taken at discharge, 45-days post-discharge, 90-days post-discharge, and 180-days post-discharge. Demographic data included sex, age, site of enrolment. </p> |
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Kind of Data: |
Restricted Access |
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Notes: |
<strong>Data Access</strong> <p>Access to these data requires submission of a formal request for consideration by our Data Governance Committee. </p> <strong>How to request</strong> <ol> <li>Download and complete the <a href="https://kemri-wellcome.org/zp-content/uploads/2021/02/KWTRP_Dataverse_Data_Request_Form_2019.docx"><strong>data request form</strong></a></li> <li> Email completed data request form to the Data Governance Committee at <a href="mailto:dgc@kemri-wellcome.org?cc=lmwango@kemri-wellcome.org?Subject=Data%20Access%20Request"><strong>dgc@kemri-wellcome.org</strong></a> </li> </ol> |
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Methodology and Processing |
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Sources Statement |
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Data Access |
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Notes: |
For access to data and more detailed information beyond the metadata and documentation provided, please send a signed data request form to [<a href="mailto:dgc@kemri-wellcome.org">dgc@kemri-wellcome.org</a> ]. <strong> <a href="https://kemri-wellcome.org/zp-content/uploads/2021/02/KWTRP_Dataverse_Data_Request_Form_2019.docx">Click to download Data Request Form</a></strong> |
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Other Study Description Materials |
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Related Publications |
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Citation |
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Title: |
Njunge JM, Tickell K, Diallo AH et al. The Childhood Acute Illness and Nutrition (CHAIN) network nested case-cohort study protocol: a multi-omics approach to understanding mortality among children in sub-Saharan Africa and South Asia [version 2; peer review: 2 approved]. Gates Open Res 2022, 6:77 |
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Identification Number: |
https://doi.org/10.12688/gatesopenres.13635.2 |
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Bibliographic Citation: |
Njunge JM, Tickell K, Diallo AH et al. The Childhood Acute Illness and Nutrition (CHAIN) network nested case-cohort study protocol: a multi-omics approach to understanding mortality among children in sub-Saharan Africa and South Asia [version 2; peer review: 2 approved]. Gates Open Res 2022, 6:77 |
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Label: |
Data.zip |
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Notes: |
application/zip |
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Label: |
EMudibo_Proteomics_Data Dictionary_June2024_.pdf |
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Notes: |
application/pdf |
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Label: |
EMudibo_Proteomics_Data Dictionary_June_2024.xlsx |
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Notes: |
application/vnd.openxmlformats-officedocument.spreadsheetml.sheet |
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Label: |
EMudibo_Proteomics_Readme_June2024.txt |
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Notes: |
text/plain |
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Label: |
Supplementary_File_S1_R_codes.R |
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Notes: |
type/x-r-syntax |
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Label: |
Supplementary_File_S1_R_codes.Rmd |
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Notes: |
text/x-r-notebook |