Replication Data for: Toxicity of ivermectin to bed bugs (Cimex hemipterus) and risk factors associated with infestation in Kwale county, coastal Kenya. (doi:10.7910/DVN/E5VVGM)

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Part 1: Document Description
Part 2: Study Description
Part 3: Data Files Description
Part 4: Variable Description
Part 5: Other Study-Related Materials
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Replication Data for: Toxicity of ivermectin to bed bugs (Cimex hemipterus) and risk factors associated with infestation in Kwale county, coastal Kenya.

doi:10.7910/DVN/E5VVGM

Harvard Dataverse

2025-02-07

1

Odongo, Tobias; Omondi, Isaiah; Wanjiku, Caroline; Okoko, Miguel; Kiuru,Caroline; Kariuki, Mercy; Ringera, Isaac; Otieno,Bruno; Yaa, Festus; Furnival-Adams, Joanna; Sanz Gutierrez, Almudena; Otuko, Rachel; Rabinovich, Regina; Mwangangi, Joseph; Chaccour, Carlos; Maia, Marta, 2025, "Replication Data for: Toxicity of ivermectin to bed bugs (Cimex hemipterus) and risk factors associated with infestation in Kwale county, coastal Kenya.", https://doi.org/10.7910/DVN/E5VVGM, Harvard Dataverse, V1, UNF:6:GOl2BK1QYQWxI1Ky/IRvcw== [fileUNF]

Replication Data for: Toxicity of ivermectin to bed bugs (Cimex hemipterus) and risk factors associated with infestation in Kwale county, coastal Kenya.

doi:10.7910/DVN/E5VVGM

Odongo, Tobias (KEMRI Centre for Vector-Borne Disease Control, Kwale, Kenya)

Omondi, Isaiah (KEMRI Wellcome Trust Research Programme, Kilifi, Kenya; KEMRI Centre for Geographic Medicine Research - Coast, Kilifi, Kenya)

Wanjiku, Caroline (KEMRI Wellcome Trust Research Programme, Kilifi, Kenya; KEMRI Centre for Geographic Medicine Research - Coast, Kilifi, Kenya)

Okoko, Miguel (KEMRI Wellcome Trust Research Programme, Kilifi, Kenya)

Kiuru,Caroline (ISGlobal, Barcelona, Spain)

Kariuki, Mercy (KEMRI Centre for Vector-Borne Disease Control, Kwale, Kenya)

Ringera, Isaac (KEMRI Wellcome Trust Research Programme, Kilifi, Kenya)

Otieno,Bruno (KEMRI Centre for Vector-Borne Disease Control, Kwale, Kenya)

Yaa, Festus (KEMRI Wellcome Trust Research Programme, Kilifi, Kenya)

Furnival-Adams, Joanna (ISGlobal, Barcelona, Spain)

Sanz Gutierrez, Almudena (ISGlobal, Barcelona, Spain)

Otuko, Rachel (KEMRI Wellcome Trust Research Programme, Kilifi, Kenya; University of Oxford, Nuffield Department of Medicine, Centre for Tropical Medicine and Global Health, Oxford, United Kingdom)

Rabinovich, Regina (ISGlobal, Barcelona, Spain; Harvard T.H. Chan School of Public Health, Boston, MA, USA)

Mwangangi, Joseph (KEMRI Wellcome Trust Research Programme, Kilifi, Kenya; KEMRI Centre for Geographic Medicine Research - Coast, Kilifi, Kenya)

Chaccour, Carlos (KEMRI Wellcome Trust Research Programme, Kilifi, Kenya; CIBER de Enfermedades Infecciosas, Madrid, Spain; Navarra Center for International Development, Universidad de Navarra, Pamplona, Spain)

Maia, Marta (KEMRI Wellcome Trust Research Programme, Kilifi, Kenya; KEMRI Centre for Geographic Medicine Research - Coast, Kilifi, Kenya; University of Oxford, Nuffield Department of Medicine, Centre for Tropical Medicine and Global Health, Oxford, United Kingdom)

Harvard Dataverse

Mwango, Lillian

Maia, Marta

2025-02-07

https://doi.org/10.7910/DVN/E5VVGM

Medicine, Health and Life Sciences, Ivermectin, endectocides, Cimex spp, Cimex hemipterus, risk factors, bed bugs, Kwale, Kenya

<p>This is a replication dataset for the manuscript titled: "<i><strong>Toxicity of ivermectin to bed bugs (Cimex hemipterus) and risk factors associated with infestation in Kwale county, coastal Kenya</strong></i>." <p>Bed bugs (Cimex spp.) are obligate ectoparasites that have long been associated with human dwellings, causing discomfort and psychosocial distress. Conventional control strategies relying on insecticides are increasingly challenged by resistance, necessitating alternative interventions. Ivermectin, an endectocide known to impact hematophagous arthropods, is currently being assessed for malaria vector control. This study aimed to evaluate the toxicity of ivermectin on Cimex hemipterus, the predominant bed bug species in Africa, within the framework of the BOHEMIA project in Kwale, Kenya. A cross-sectional survey was done in 2393 households to obtain information on self-reported bed bug infestations, socio economic status, and household characteristics. Bed bugs were collected from 40 infested households in the control arm of the BOHEMIA trial. After collection, bed bugs were acclimatized and exposed to blood meals spiked with ivermectin at five concentrations (11 ng/ml, 21 ng/ml, 43 ng/ml, 64 ng/ml, and 85 ng/ml), corresponding to expected serum levels following a 400 mcg/kg oral dose. Mortality and fecundity were monitored over a 14-day period. Statistical analyses, including Cox proportional hazard models and probit regression, were applied to assess dose-response relationships.</p>

Open Access

• Number of cases: 2393

• No. of variables per record: 8

• Type of File: text/tab-separated-values

UNF:6:XelH/A8OCv6tLH3kcLB80Q==

• Number of cases: 40

• No. of variables per record: 5

• Type of File: text/tab-separated-values

UNF:6:U1IvOYy0ZRLtODboZp/3QA==

• cluster - cluster
• hhid - hhid
• wealthindexrank - wealthindexrank
• num_cattle_total - num_cattle_total
• bedbug_present - bedbug_present
• cattle_sleepwith50m - cattle_sleepwith50m
• wall2 - wall2
• roof2 - roof2
• Tr_Baseline - Tr_Baseline
• Cum_tr - Cum_tr
• dose_ng/ml - dose_ng/ml
• IVM_dose - IVM_dose
• Time_hrs - Time_hrs

f10873228 Location:

Summary Statistics: Mean 59.56790639364851; Valid 2393.0; Min. 5.0; Max. 96.0; StDev 28.82531008232877;

Variable Format: numeric

Notes: UNF:6:9b14ZyrHMjBigoWzRxgOvQ==

f10873228 Location:

Summary Statistics: Valid 2393.0; StDev 28833.289497092992; Mean 59621.39490179668; Min. 5006.0; Max. 96063.0;

Variable Format: numeric

Notes: UNF:6:uhFkG6FQO4NGXc7TAL50Sw==

f10873228 Location:

Variable Format: character

Notes: UNF:6:z33fTS5V6ygyitnCOPU8Kw==

f10873228 Location:

Summary Statistics: StDev 8.154322025268241; Mean 7.580049261083741; Max. 41.0; Min. 1.0; Valid 812.0;

Variable Format: numeric

Notes: UNF:6:szZEoKOh9SgAZsDszN/7zg==

f10873228 Location:

Summary Statistics: Max. 1.0; StDev 0.4900684771248092; Min. 0.0; Valid 2393.0; Mean 0.5996656916005004;

Variable Format: numeric

Notes: UNF:6:/xCnlZf3kBS3sMzWzUgbPg==

f10873228 Location:

Summary Statistics: Valid 800.0; Max. 1.0; Mean 0.5587500000000001; StDev 0.4968470677793638; Min. 0.0

Variable Format: numeric

Notes: UNF:6:vVpezm8/upN5Ca48xVcjng==

f10873228 Location:

Variable Format: character

Notes: UNF:6:yrz8zLJqpSpGbPOSHEFKrw==

f10873228 Location:

Variable Format: character

Notes: UNF:6:PlzRQsthJ3Pu0avY5OYuXA==

f10873226 Location:

Summary Statistics: Valid 40.0; Max. 143.0; StDev 18.430743546919306; Min. 94.0; Mean 116.0

Variable Format: numeric

Notes: UNF:6:czbDrc0aUMdJcauOOWNpqQ==

f10873226 Location:

Summary Statistics: StDev 44.98169855761568; Max. 131.0; Min. 0.0; Mean 65.67500000000001; Valid 40.0

Variable Format: numeric

Notes: UNF:6:u+3VNAxSaQHvONPJVmjXkA==

f10873226 Location:

Variable Format: character

Notes: UNF:6:pOhRJDqXu2O4sdkKI4qmHw==

f10873226 Location:

Summary Statistics: Mean 44.79999999999999; Max. 85.0; Valid 40.0; Min. 11.0; StDev 27.537573399229437;

Variable Format: numeric

Notes: UNF:6:0EtwZ+vN2wjoynXxUARNGg==

f10873226 Location:

Summary Statistics: Mean 84.125; Min. 1.0; StDev 55.498758359869456; Valid 40.0; Max. 168.0;

Variable Format: numeric

Notes: UNF:6:/Y/rXa6EVbESTdF/P3PsnA==

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analysis_codes.R

type/x-r-syntax

Label:

bed bug oviposition.csv

text/csv

Label:

bed bug survival.csv

text/csv

Label:

bedbug_data.xlsx

Text:

This Excel workbook includes all the files presented here in CSV format.

application/vnd.openxmlformats-officedocument.spreadsheetml.sheet

Label:

Maia_BedBug IVM_Data Dictionary_v2.pdf

application/pdf

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Maia_BedBug IVM_Readme.txt

text/plain