New antigens for multi-component blood-stage vaccines against Plasmodium falciparum malaria  (doi:10.7910/DVN/EULHTX)

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Part 1: Document Description
Part 2: Study Description
Part 3: Data Files Description
Part 4: Variable Description
Part 5: Other Study-Related Materials
Entire Codebook

New antigens for multi-component blood-stage vaccines against Plasmodium falciparum malaria

doi:10.7910/DVN/EULHTX

Harvard Dataverse

2017-09-06

1

Osier, Faith; Kamuyu, Gathoni; Crosnier, Cécile; Wanaguru, Madushi; Oganda, Edna; McDade, Brian, 2017, "New antigens for multi-component blood-stage vaccines against Plasmodium falciparum malaria", https://doi.org/10.7910/DVN/EULHTX, Harvard Dataverse, V1, UNF:6:cFbr0Rlt8Ja7gGJDfq93mg== [fileUNF]

New antigens for multi-component blood-stage vaccines against Plasmodium falciparum malaria

doi:10.7910/DVN/EULHTX

Osier, Faith (Bioscience department, Kenya Medical Research Institute - Centre of Geographical Medicine Research, Coast, Post Office Box 230-80108, Kilifi, Kenya)

Kamuyu, Gathoni (Bioscience department, Kenya Medical Research Institute - Centre of Geographical Medicine Research, Coast, Post Office Box 230-80108, Kilifi, Kenya)

Crosnier, Cécile (Cell Surface Signalling Laboratory, Wellcome Trust Sanger Institute, Cambridge CB10 1HH, UK; Malaria programme, Wellcome Trust Sanger Institute, Cambridge CB10 1SA, UK)

Wanaguru, Madushi (Cell Surface Signalling Laboratory, Wellcome Trust Sanger Institute, Cambridge CB10 1HH, UK; Malaria programme, Wellcome Trust Sanger Institute, Cambridge CB10 1SA, UK)

Oganda, Edna (Bioscience department, Kenya Medical Research Institute - Centre of Geographical Medicine Research, Coast, Post Office Box 230-80108, Kilifi, Kenya)

McDade, Brian (Cell Surface Signalling Laboratory, Wellcome Trust Sanger Institute, Cambridge CB10 1HH, UK)

Harvard Dataverse

Osier, Faith

Osier, Faith

2017-08-06

https://doi.org/10.7910/DVN/EULHTX

Medicine, Health and Life Sciences, Malaria, Merozoite, Plasmodium falciparum, Immunity, Vaccine

<p>This dataset is from a prospective longitudinal cohort study of children from Chonyi village in Kilifi County, Kenya. The study was conducted for the purpose of evaluating the potential protective efficacy of antibodies to Plasmodium falciparum antigens against clinical episodes of malaria. Venous blood was collected from 286 children (age 1-10 years old) during a cross-sectional survey at the start of a malaria transmission season. Thick and thin blood smears were prepared for parasite detection by microscopy. Plasma was used to measure antibody levels to 39 Plasmodium falciparum merozoite surface and secreted proteins by enzyme linked immunosorbent assay. The children were then followed up for a period of 6 months with both active (Weekly home visits) and passive surveillance for malaria case detection.</p>

This data is made available under the Creative Commons Attribution 4.0 International (CC BY 4.0) - https://creativecommons.org/licenses/by/4.0/legalcode. Publications based on these data should acknowledge this source by means of bibliographic citations. For more information on these data, please contact the author via FOsier@kemri-wellcome.org or the data governance office via this email address: dgc@kemri-wellcome.org

This dataset is available on open access. Please contact the author via FOsier@kemri-wellcome.org OR the Data Governance Committee via dgc@kemri-wellcome.org" for any clarifications

Osier, F. H., M. J. Mackinnon, C. Crosnier, G. Fegan, G. Kamuyu, M. Wanaguru, E. Ogada, B. McDade, J. C. Rayner, G. J. Wright and K. Marsh (2014). "New antigens for a multicomponent blood-stage malaria vaccine." Sci Transl Med 6(247): 247ra102.10. DOI: 1126/scitranslmed.3008705 URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4856877/

1126/scitranslmed.3008705

Osier, F. H., M. J. Mackinnon, C. Crosnier, G. Fegan, G. Kamuyu, M. Wanaguru, E. Ogada, B. McDade, J. C. Rayner, G. J. Wright and K. Marsh (2014). "New antigens for a multicomponent blood-stage malaria vaccine." Sci Transl Med 6(247): 247ra102.10. DOI: 1126/scitranslmed.3008705 URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4856877/

• Number of cases: 286

• No. of variables per record: 44

• Type of File: text/tab-separated-values

UNF:6:cFbr0Rlt8Ja7gGJDfq93mg==

Dataset (csv)

• serialno - serialno
• p_mal4 - p_mal4
• mal4 - mal4
• t_to_mal4 - t_to_mal4
• pf_screen - pf_screen
• ageyrs - ageyrs
• agecat - agecat
• _schizont - _schizont
• msp1 - msp1
• msp2 - msp2
• msp4 - msp4
• msp5 - msp5
• msp10 - msp10
• pf12 - pf12
• pf38 - pf38
• pf92 - pf92
• pf34 - pf34
• pf113 - pf113
• gama - gama
• ama1 - ama1
• eba175 - eba175
• eba140 - eba140
• eba181 - eba181
• mtrap - mtrap
• asp - asp
• msp3 - msp3
• msp6 - msp6
• msp7 - msp7
• msp9 - msp9
• msrp1 - msrp1
• msrp2 - msrp2
• msrp3 - msrp3
• h101 - h101
• h103 - h103
• pf41 - pf41
• pff0335c - pff0335c
• rama - rama
• rhoph3 - rhoph3
• rh5 - rh5
• ron6 - ron6
• pf10_0323 - pf10_0323
• tlp - tlp
• pf11_0373 - pf11_0373
• pf14_0344 - pf14_0344

f3041271 Location:

Variable Format: character

Notes: UNF:6:+tJva2fW3O56OT0DGNPLgA==

f3041271 Location:

Summary Statistics: Mean 0.24475524475524463; Min. 0.0; StDev 0.43069561387887584; Valid 286.0; Max. 1.0;

Variable Format: numeric

Notes: UNF:6:CmJDisyJnwiQAlrLGm00ew==

f3041271 Location:

Summary Statistics: Min. 0.0; Valid 286.0; Mean 0.36013986013986027; StDev 0.7537173242880314; Max. 5.0

Variable Format: numeric

Notes: UNF:6:rrDB3iK4JUBLt9Qvh3XCDg==

f3041271 Location:

Summary Statistics: StDev 7.894996248907216; Valid 286.0; Max. 26.0; Mean 21.91808195104895; Min. 1.285714

Variable Format: numeric

Notes: UNF:6:PbrwaHmEZ04vGamLKJj4Cg==

f3041271 Location:

Summary Statistics: Min. 0.0; Max. 1.0; Mean 0.42307692307692285; StDev 0.4949133977324318; Valid 286.0;

Variable Format: numeric

Notes: UNF:6:h/4A2UH6wXqdeZ1Zfrq+6g==

f3041271 Location:

Summary Statistics: Valid 286.0; Mean 5.622377622377619; Max. 10.0; Min. 1.0; StDev 2.8978012131504287

Variable Format: numeric

Notes: UNF:6:pQlyrVA/1aCWWQ+UrWNPsA==

f3041271 Location:

Summary Statistics: Min. 1.0; Valid 286.0; StDev 1.424986036517344; Mean 3.03146853146853; Max. 5.0;

Variable Format: numeric

Notes: UNF:6:VAYVFdqL5dIHZp0UVxe6AQ==

f3041271 Location:

Summary Statistics: Valid 286.0; Min. -0.0294333; StDev 0.5054305119118345; Max. 1.9015; Mean 1.112938829020979

Variable Format: numeric

Notes: UNF:6:lh7tO6hv1AGkFE6S6gFvCw==

f3041271 Location:

Summary Statistics: Mean 0.42405069825174824; Valid 286.0; Max. 1.139; Min. 0.04; StDev 0.3063667290596415

Variable Format: numeric

Notes: UNF:6:g+g6/bA+uGEIX21johtFdg==

f3041271 Location:

Summary Statistics: Valid 286.0; Mean 0.08299825174825175; Min. 0.0385; Max. 0.553; StDev 0.08060643501206305

Variable Format: numeric

Notes: UNF:6:KCKWgEZPKpFf4yE8pyhlKQ==

f3041271 Location:

Summary Statistics: StDev 0.3451152173901564; Max. 1.602; Mean 0.3715437066433566; Min. 0.089; Valid 286.0

Variable Format: numeric

Notes: UNF:6:TuOyOv0duIcjMyzoqUB9Dg==

f3041271 Location:

Summary Statistics: Max. 0.481; Valid 282.0; Min. 0.0475; StDev 0.05561733560330638; Mean 0.1016436170212766

Variable Format: numeric

Notes: UNF:6:lQrnAHIYdcmaiHjLARuW7Q==

f3041271 Location:

Summary Statistics: Valid 286.0; Min. 0.0795; Max. 1.8525; Mean 0.5183863639860139; StDev 0.4395417410537532;

Variable Format: numeric

Notes: UNF:6:WDBQiwIyZt/D2ghgDh3Tdg==

f3041271 Location:

Summary Statistics: Valid 286.0; Max. 0.6375; StDev 0.1003768485841699; Min. 0.0675; Mean 0.13837587412587413

Variable Format: numeric

Notes: UNF:6:9qFA92FUcQH75UvF09wAsw==

f3041271 Location:

Summary Statistics: Valid 286.0; Max. 1.249; Min. 0.0405; Mean 0.23721853216783215; StDev 0.2795373423461528;

Variable Format: numeric

Notes: UNF:6:RQ9FuoH9CPWMTkEmCoD7fw==

f3041271 Location:

Summary Statistics: Mean 0.5666486013986014; Valid 286.0; Max. 1.3735; Min. 0.038; StDev 0.4553766435482447;

Variable Format: numeric

Notes: UNF:6:1lKRl4tX/fKRrogzVbKTKg==

f3041271 Location:

Summary Statistics: Min. 0.032; StDev 0.02615823503862896; Max. 0.1915; Valid 286.0; Mean 0.06943881118881119

Variable Format: numeric

Notes: UNF:6:g2SR4Sw/9nEWQBLZVKQfkg==

f3041271 Location:

Summary Statistics: Max. 0.3885; StDev 0.04504379267441728; Mean 0.07270629370629371; Valid 286.0; Min. 0.039

Variable Format: numeric

Notes: UNF:6:/jYMI6aLgqb+vewIxfyHOw==

f3041271 Location:

Summary Statistics: StDev 0.02163697908542397; Mean 0.05302797202797203; Valid 286.0; Min. 0.0325; Max. 0.2075

Variable Format: numeric

Notes: UNF:6:Rk7YopNGHKTpqqmr3RC78w==

f3041271 Location:

Summary Statistics: StDev 0.33808353996753815; Max. 1.1595; Valid 286.0; Mean 0.35521328811188807; Min. 0.0325;

Variable Format: numeric

Notes: UNF:6:z1WhpEAIPjPeiQuHGIl9ug==

f3041271 Location:

Summary Statistics: StDev 0.46174515636804847; Min. 0.0855; Max. 1.949; Valid 286.0; Mean 0.3723811192307693;

Variable Format: numeric

Notes: UNF:6:dw8NxhJBOznPZsEqHa3pUw==

f3041271 Location:

Summary Statistics: Valid 286.0; Max. 1.744; Min. 0.084; Mean 0.316078670979021; StDev 0.35922568228192614;

Variable Format: numeric

Notes: UNF:6:IK+rf3xFQpkJX5yu9YhxLg==

f3041271 Location:

Summary Statistics: Max. 1.728; Valid 286.0; StDev 0.3427511678861959; Mean 0.299805944055944; Min. 0.075

Variable Format: numeric

Notes: UNF:6:aYAQwwjm5UUOTLOb3nCdSg==

f3041271 Location:

Summary Statistics: Mean 0.055744755244755244; Valid 286.0; Max. 0.234; Min. 0.039; StDev 0.02307895427203671

Variable Format: numeric

Notes: UNF:6:J+KTedVDNCBxOMP6+xMfEg==

f3041271 Location:

Summary Statistics: Valid 286.0; Min. 0.063; StDev 0.02394642478467509; Mean 0.08945454545454545; Max. 0.2435

Variable Format: numeric

Notes: UNF:6:0XprpvOmHj6EDHwzCjdiJg==

f3041271 Location:

Summary Statistics: Max. 0.651; Valid 286.0; Min. 0.035; StDev 0.09338313178802456; Mean 0.10127797202797202;

Variable Format: numeric

Notes: UNF:6:nspoMbu8YvwTzAa0L3T89Q==

f3041271 Location:

Summary Statistics: Mean 0.14668006993006993; Min. 0.086; Max. 0.9075; Valid 286.0; StDev 0.07983797136434542

Variable Format: numeric

Notes: UNF:6:AaRJlpWJ7Ij4i0Gm+GQgKw==

f3041271 Location:

Summary Statistics: Min. 0.0835; StDev 0.3467351043137817; Mean 0.38192832167832164; Max. 1.411; Valid 286.0

Variable Format: numeric

Notes: UNF:6:eBiiGtodriwBnDwagc0oQw==

f3041271 Location:

Summary Statistics: Mean 0.0971048951048951; Min. 0.0375; Max. 0.5595; StDev 0.08013475171293798; Valid 286.0;

Variable Format: numeric

Notes: UNF:6:YVhdxO8ohgW30ZvUbX0w7w==

f3041271 Location:

Summary Statistics: Max. 0.386; Valid 286.0; StDev 0.05474718139494223; Min. 0.04; Mean 0.0791048951048951

Variable Format: numeric

Notes: UNF:6:kTgEIZyO7eDWBkoJgHYYHw==

f3041271 Location:

Summary Statistics: Min. 0.041; Mean 0.06925349650349649; StDev 0.041546121971725136; Valid 286.0; Max. 0.3325;

Variable Format: numeric

Notes: UNF:6:18ThEg2ZxznEPSSeAjlByQ==

f3041271 Location:

Summary Statistics: Min. 0.033; Max. 0.248; StDev 0.03128652183111049; Valid 286.0; Mean 0.05693356643356644

Variable Format: numeric

Notes: UNF:6:7mJhLNaRatNhXOETkP3EmA==

f3041271 Location:

Summary Statistics: StDev 0.04046190870821731; Max. 0.669; Mean 0.055117132867132865; Valid 286.0; Min. 0.0405

Variable Format: numeric

Notes: UNF:6:eSl/7piNg1JjSPtIiNDH6w==

f3041271 Location:

Summary Statistics: StDev 0.0550465352536402; Max. 0.3915; Valid 286.0; Min. 0.036; Mean 0.08047027972027973;

Variable Format: numeric

Notes: UNF:6:frug+P4JhfaGzs6czb5RNQ==

f3041271 Location:

Summary Statistics: Valid 286.0; Max. 1.1495; Mean 0.11294055944055943; StDev 0.1391290892371779; Min. 0.0385

Variable Format: numeric

Notes: UNF:6:wAjv25qIfePl/AxdG4F3CQ==

f3041271 Location:

Summary Statistics: Max. 0.684; StDev 0.0883782979887709; Min. 0.0395; Valid 286.0; Mean 0.09787062937062938

Variable Format: numeric

Notes: UNF:6:INdrTbJ+RsiWGfh3enroxA==

f3041271 Location:

Summary Statistics: Max. 0.195; Min. 0.0385; Mean 0.06419055944055944; StDev 0.02771622265537674; Valid 286.0

Variable Format: numeric

Notes: UNF:6:T6B0H2tK3lgjbAKwKYntdg==

f3041271 Location:

Summary Statistics: StDev 0.047020552310561334; Min. 0.039; Max. 0.446; Valid 286.0; Mean 0.06853146853146853;

Variable Format: numeric

Notes: UNF:6:FoEKXWtsjHJtf1SMm1ZkLw==

f3041271 Location:

Summary Statistics: Max. 1.4075; Min. 0.073; StDev 0.09786615797142961; Valid 286.0; Mean 0.1386625874125874;

Variable Format: numeric

Notes: UNF:6:j6whfS6YTkmDRnt3td8gjQ==

f3041271 Location:

Summary Statistics: Valid 286.0; StDev 0.023802463314653334; Min. 0.0395; Mean 0.052263986013986005; Max. 0.192;

Variable Format: numeric

Notes: UNF:6:FlQlSrzFvd/XYaQX4T9sxg==

f3041271 Location:

Summary Statistics: Mean 0.04817657342657342; Max. 0.11; StDev 0.009257682071674501; Min. 0.04; Valid 286.0;

Variable Format: numeric

Notes: UNF:6:AWbI0Bxxzd0sDcLpEvCzxA==

f3041271 Location:

Summary Statistics: Valid 282.0; StDev 0.009705327033778344; Max. 0.105; Mean 0.04671808510638298; Min. 0.0405;

Variable Format: numeric

Notes: UNF:6:HcWLrkUarEDXdlzgvkj2cg==

f3041271 Location:

Summary Statistics: StDev 0.021795986815604282; Mean 0.06981914893617021; Min. 0.041; Valid 282.0; Max. 0.192

Variable Format: numeric

Notes: UNF:6:HWY0kjSqKc6bW0Q/FUVn8Q==

f3041271 Location:

Summary Statistics: Mean 0.07932624113475177; Max. 0.712; StDev 0.042240288143007274; Valid 282.0; Min. 0.056

Variable Format: numeric

Notes: UNF:6:wRQAHZ2SQ9TFNP5ivvqGSw==

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Osier_et_al_2014_ScienceTranslationalMedicine.pdf

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Osier_et_al_2017_codebook.pdf

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Variable codebook

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Osier_et_al_2017_ReadmeFile.txt

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Readme file

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