Replication Data for: Absence of Association between Cord Specific Antibody Levels and Severe Respiratory Syncytial Virus (RSV) Disease in Early Infants: A Case Control Study from Coastal Kenya (doi:10.7910/DVN/FOIUHT)

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Part 1: Document Description
Part 2: Study Description
Part 3: Data Files Description
Part 4: Variable Description
Part 5: Other Study-Related Materials
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Replication Data for: Absence of Association between Cord Specific Antibody Levels and Severe Respiratory Syncytial Virus (RSV) Disease in Early Infants: A Case Control Study from Coastal Kenya

doi:10.7910/DVN/FOIUHT

Harvard Dataverse

2016-11-29

2

Nokes, David james; Scott, John Anthony G.; Nyiro, Joyce Uchi, 2016, "Replication Data for: Absence of Association between Cord Specific Antibody Levels and Severe Respiratory Syncytial Virus (RSV) Disease in Early Infants: A Case Control Study from Coastal Kenya", https://doi.org/10.7910/DVN/FOIUHT, Harvard Dataverse, V2, UNF:6:2aPIb7AM6ZBUQgMtdADXzw== [fileUNF]

Replication Data for: Absence of Association between Cord Specific Antibody Levels and Severe Respiratory Syncytial Virus (RSV) Disease in Early Infants: A Case Control Study from Coastal Kenya

doi:10.7910/DVN/FOIUHT

Nokes, David james (Kemri Wellcome Trust Research programme)

Scott, John Anthony G. (Kemri Wellcome Trust Research programme)

Nyiro, Joyce Uchi (Kemri Wellcome Trust Research programme)

Harvard Dataverse

Nyiro, Joyce Uchi

Nokes, David James

2016-11-29

https://doi.org/10.7910/DVN/FOIUHT

Medicine, Health and Life Sciences

This dataset was generated from a study nested within a previous Kilifi Birth Cohort (KBC) study, conducted between 1999 and 2007 at KEMRI-Wellcome Trust Research Programme, KEMRI CGMR-C, Kilifi, Kenya. The KBC resulted in an archive of cord and three-monthly follow-up sera from infants. The nested study involved selection from this dataset cases defined as severe RSV antigen confirmed infants admitted to Kilifi County Hospital (KCH), and controls defined as infants without documented severe RSV hospitalization matched to the case by date of birth and geographical location. Stored cord and follow samples from these cases and controls were screened for RSV specific neutralizing antibodies by the plaque reduction neutralisation test (PRNT). A comparison was made between levels of specific antibody at birth (and also rates of specific antibody decay in first 6 months of life) for cases and controls. The study arose out of interest shown by the Program for Appropriate Technology in Health (PATH) in maternal boosting as a vaccination strategy and in quantifying protective levels of neutralizing antibodies.

<a href="http://creativecommons.org/publicdomain/zero/1.0">CC0 1.0</a>

• Number of cases: 90

• No. of variables per record: 39

• Type of File: text/tab-separated-values

UNF:6:2aPIb7AM6ZBUQgMtdADXzw==

Existing PLoS Journals DOI: 10.1371/journal.pone.0166706.s001

• studyno - studyno
• dob -  dob
• date_admn -  date_admn
• iage_months - iage_months
• iage_mths_new - iage_mths_new
• assignment - assignment
• case - case
• matchset - matchset
• control - control
• serum0 - serum0
• titre0 - titre0
• serum1 - serum1
• date_collect1 -  date_collect1
• titre1 - titre1
• serum2 - serum2
• date_collect2 -  date_collect2
• titre2 - titre2
• serum3 - serum3
• date_collect3 -  date_collect3
• titre3 - titre3
• ntitre0 - ntitre0
• ntitre1 - ntitre1
• ntitre2 - ntitre2
• ntitre3 - ntitre3
• bwt - bwt
• lmp -  lmp
• gestation_period - gestation_period
• gest_agew - gest_agew
• underwt - underwt
• controlno - controlno
• cases - cases
• age_cat - age_cat
• premature - premature
• Iga_od1 - Iga_od1
• iga_od2 - iga_od2
• iga_od3 - iga_od3
• Iga_logau1 - Iga_logau1
• logau2 - logau2
• Iga_logau3 - Iga_logau3

f2961875 Location:

Summary Statistics: Valid 90.0; Min. 4093.0; Max. 9503.0; Mean 6895.844444444443; StDev 1342.4494961405028

Variable Format: numeric

Notes: UNF:6:+zagLZkHxbEwszmhz9MGSg==

f2961875 Location:

Variable Format: character

Notes: UNF:6:upj/H3q8GX8uTNCy8rBxrQ==

f2961875 Location:

Variable Format: character

Notes: UNF:6:BJdyfrC6TR8XGEahr0rHMQ==

f2961875 Location:

Summary Statistics: Valid 30.0; Max. 5.0; Min. 0.0; StDev 1.5698305055298023; Mean 2.533333333333333

Variable Format: numeric

Notes: UNF:6:uKOXoMDAuIG3mYcEHvYA5A==

f2961875 Location:

Summary Statistics: Min. 0.0; Mean 2.533333333333333; StDev 1.5520917382825483; Valid 90.0; Max. 5.0

Variable Format: numeric

Notes: UNF:6:kYXFQrS1N3dtyjAXIEBP0Q==

f2961875 Location:

Variable Format: character

Notes: UNF:6:kW07SY5+MlBVYXegQSn90Q==

f2961875 Location:

Summary Statistics: Valid 90.0; StDev 1336.3147479609656; Min. 4131.0; Max. 9445.0; Mean 6892.866666666665;

Variable Format: numeric

Notes: UNF:6:+3xrCi2BsIdZ0hQWQ2lCAg==

f2961875 Location:

Summary Statistics: Min. 3.0; Max. 55.0; StDev 13.837134534824449; Valid 90.0; Mean 30.166666666666654;

Variable Format: numeric

Notes: UNF:6:6p1dumVTPT1dO/XTQTKm2g==

f2961875 Location:

Summary Statistics: StDev 1342.4494961405028; Max. 9503.0; Mean 6895.844444444443; Valid 90.0; Min. 4093.0

Variable Format: numeric

Notes: UNF:6:+zagLZkHxbEwszmhz9MGSg==

f2961875 Location:

Variable Format: character

Notes: UNF:6:YQhUeodpddO06eHTvHA9gA==

f2961875 Location:

Summary Statistics: Max. 6088.74; Min. 258.125; Valid 90.0; Mean 2188.672666666667; StDev 1357.2076666108296;

Variable Format: numeric

Notes: UNF:6:5Pbzu6imZcD9Le8hJX2tgg==

f2961875 Location:

Variable Format: character

Notes: UNF:6:LlBpe5bK9Yc1ySAaDlAhzg==

f2961875 Location:

Variable Format: character

Notes: UNF:6:uHgLQiTPvHBHlzUuwrM/8w==

f2961875 Location:

Summary Statistics: Valid 83.0; Min. 58.563; Max. 3853.432; Mean 905.9600361445783; StDev 758.1070214175544

Variable Format: numeric

Notes: UNF:6:rTeQlwo/blqYlPiLqZjBLQ==

f2961875 Location:

Variable Format: character

Notes: UNF:6:zlUFkfSaP5BT8fp7Z8jFgg==

f2961875 Location:

Variable Format: character

Notes: UNF:6:2UPK/5yU3mhJjBa9pu6t5w==

f2961875 Location:

Summary Statistics: Min. 31.821; Max. 5300.556; StDev 880.9444825213758; Valid 61.0; Mean 607.7104606557377

Variable Format: numeric

Notes: UNF:6:MvpXU8SB3AsZRCrse0/ZTQ==

f2961875 Location:

Variable Format: character

Notes: UNF:6:uWes6Deo+Dne6Lmffrvsig==

f2961875 Location:

Variable Format: character

Notes: UNF:6:y+Gv+gXhZz8tKZ6mSyV0HQ==

f2961875 Location:

Summary Statistics: Mean 1165.3450266666666; Min. 347.755; Max. 2775.621; Valid 15.0; StDev 827.0816525964319;

Variable Format: numeric

Notes: UNF:6:3yJOd+ziI8OeOQdQIKEdWA==

f2961875 Location:

Summary Statistics: Max. 12.57193; Valid 90.0; Mean 10.774921422222222; Min. 8.011926; StDev 1.0310978034213303;

Variable Format: numeric

Notes: UNF:6:u6B79it57b+6zorq6JW27A==

f2961875 Location:

Summary Statistics: Max. 11.91193; Min. 5.871918; Valid 83.0; StDev 1.2736868358487952; Mean 9.329779180722891

Variable Format: numeric

Notes: UNF:6:Ss/YWBy0xEcdcYrQUO7Tog==

f2961875 Location:

Summary Statistics: StDev 1.5536829487945505; Min. 4.991907; Mean 8.386424655737706; Max. 12.37193; Valid 61.0

Variable Format: numeric

Notes: UNF:6:LDzCzk6/4BFatesQ0PWi7Q==

f2961875 Location:

Summary Statistics: Min. 8.441928; Valid 15.0; Max. 11.43859; StDev 1.0071884647667106; Mean 9.856594866666667

Variable Format: numeric

Notes: UNF:6:AV4gSdGOhl93n8tpr8/RbA==

f2961875 Location:

Summary Statistics: Max. 3.97; Mean 2.8755555555555556; Min. 1.45; StDev 0.5291171892879686; Valid 81.0

Variable Format: numeric

Notes: UNF:6:I0VNkR2GNiwB67iwdip+Wg==

f2961875 Location:

Variable Format: character

Notes: UNF:6:qDZZBbGVwwa2thSM+LKKfg==

f2961875 Location:

Summary Statistics: Max. 534.0; Valid 63.0; Min. 200.0; Mean 273.2857142857143; StDev 39.29147842087005

Variable Format: numeric

Notes: UNF:6:AGtGsAU8yw3LpP17DVBC3w==

f2961875 Location:

Summary Statistics: Min. 28.57143; Max. 43.0; Mean 38.44009274193549; StDev 2.985893115331518; Valid 62.0

Variable Format: numeric

Notes: UNF:6:WVqqlnsgRriUQPGe1LhvHw==

f2961875 Location:

Summary Statistics: Min. 0.0; Mean 0.1666666666666667; Valid 90.0; Max. 1.0; StDev 0.37476584449793093

Variable Format: numeric

Notes: UNF:6:Rr8IWOm8Z5eZ41bfTz+mYw==

f2961875 Location:

Summary Statistics: Mean 1.5; StDev 0.5042194840896107; Min. 1.0; Max. 2.0; Valid 60.0;

Variable Format: numeric

Notes: UNF:6:Wqs4eiyU0IiSo973B8g+FA==

f2961875 Location:

Summary Statistics: Mean 0.33333333333333337; Valid 90.0; Max. 1.0; StDev 0.4740454631399769; Min. 0.0

Variable Format: numeric

Notes: UNF:6:0oaB2Vqbgwx5P7TeHmHnLQ==

f2961875 Location:

Summary Statistics: StDev 1.4949352697271392; Mean 3.7; Valid 90.0; Max. 5.0; Min. 2.0

Variable Format: numeric

Notes: UNF:6:iR62xeDrg6gmkIaK8qLlSQ==

f2961875 Location:

Summary Statistics: Max. 1.0; Mean 0.5; Valid 62.0; StDev 0.5040817003777639; Min. 0.0

Variable Format: numeric

Notes: UNF:6:KeHDG1LVIFoWL6lJwEBzvw==

f2961875 Location:

Summary Statistics: Mean 0.13185849056603774; Min. 0.071; Valid 53.0; Max. 0.325; StDev 0.05842857057310452

Variable Format: numeric

Notes: UNF:6:kgdE2zPIJQip043q93zNIQ==

f2961875 Location:

Summary Statistics: Valid 52.0; Min. 0.0905; StDev 0.5327005892599409; Mean 0.3163846153846154; Max. 3.0

Variable Format: numeric

Notes: UNF:6:n1djqu0t64kfQ1jtUcoLZQ==

f2961875 Location:

Summary Statistics: Max. 3.242; Valid 43.0; Min. 0.0975; StDev 0.5662992739385637; Mean 0.4078255813953488;

Variable Format: numeric

Notes: UNF:6:w+ftktHlsVuQK8EjIOzFLA==

f2961875 Location:

Summary Statistics: Valid 53.0; StDev 0.06464259774901479; Min. 1.34348; Mean 1.5096149056603774; Max. 1.637126

Variable Format: numeric

Notes: UNF:6:zK5HROoSIsjNzDwPj34rzQ==

f2961875 Location:

Summary Statistics: StDev 0.716563500607082; Mean 1.7453548653846154; Max. 5.834039; Min. 1.396137; Valid 52.0

Variable Format: numeric

Notes: UNF:6:8Wnx4N318UXvhEpeztjbiw==

f2961875 Location:

Summary Statistics: Mean 1.844803738095238; Valid 42.0; Max. 5.114899; Min. 1.44105; StDev 0.6651359892187851;

Variable Format: numeric

Notes: UNF:6:6tf5vOj1XG9YWUkCghjVsg==

Label:

journal.pone.0166706.pdf

Text:

Article

application/pdf

Label:

PATH_KBC_casecontrol_data_analysis.do

Text:

data analysis code

application/x-stata-syntax

Label:

readme.txt

text/plain

Label:

RSV data dictionary.pdf

Text:

variable codebook Existing PLoS Journals DOI: 10.1371/journal.pone.0166706.s002

application/pdf