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Part 1: Document Description
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Citation |
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Title: |
Replication Data for: Comparative performance of the InBios SCoV-2 DetectTM IgG ELISA and the in-house KWTRP ELISA in detecting SARS-CoV-2 spike IgG antibodies in Kenyan populations |
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Identification Number: |
doi:10.7910/DVN/FOYVMT |
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Distributor: |
Harvard Dataverse |
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Date of Distribution: |
2023-08-10 |
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Version: |
2 |
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Bibliographic Citation: |
Kutima, Bernadette; Kagucia,Wangeci; Mwai, Kennedy; Kimani, Makobu; Sigilai, Antipa; Mugo, Daisy; Karani, Angela; Akech, Donald; Toroitich, Monica; Karia, Boniface; Tuju, James; Ziraba, Abdhalah K.; Bigogo,Godfrey; Ochieng, Caroline; Onyango, Clayton; Lidechi, Shirley; Munywoki,Patrick K.; Uyoga, Sophie; Adetifa, Ifedayo M. O.; Ochola-Oyier,Lynette I.; Bejon, Philip; Scott,J. Anthony G.; Agweyu, Ambrose; Warimwe, George M.; Nyagwange, James, 2023, "Replication Data for: Comparative performance of the InBios SCoV-2 DetectTM IgG ELISA and the in-house KWTRP ELISA in detecting SARS-CoV-2 spike IgG antibodies in Kenyan populations", https://doi.org/10.7910/DVN/FOYVMT, Harvard Dataverse, V2 |
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Citation |
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Title: |
Replication Data for: Comparative performance of the InBios SCoV-2 DetectTM IgG ELISA and the in-house KWTRP ELISA in detecting SARS-CoV-2 spike IgG antibodies in Kenyan populations |
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Identification Number: |
doi:10.7910/DVN/FOYVMT |
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Authoring Entity: |
Kutima, Bernadette (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya) |
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Kagucia,Wangeci (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya) |
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Mwai, Kennedy (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya) |
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Kimani, Makobu (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya) |
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Sigilai, Antipa (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya) |
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Mugo, Daisy (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya) |
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Karani, Angela (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya) |
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Akech, Donald (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya) |
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Toroitich, Monica (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya) |
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Karia, Boniface (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya) |
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Tuju, James (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya) |
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Ziraba, Abdhalah K. (African Population and Health Research Center) |
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Bigogo,Godfrey (Kenya Medical Research Institute Centre for Global Health Research) |
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Ochieng, Caroline (Kenya Medical Research Institute) |
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Onyango, Clayton (Kenya Medical Research Institute Centre for Global Health Research) |
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Lidechi, Shirley (Kenya Medical Research Institute Centre for Global Health Research) |
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Munywoki,Patrick K. (United States Centers for Disease Control and Prevention, Global Health Center, Division of Global Health Protection, Nairobi, Kenya) |
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Uyoga, Sophie (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya) |
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Adetifa, Ifedayo M. O. (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya) |
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Ochola-Oyier,Lynette I. (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya) |
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Bejon, Philip (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya) |
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Scott,J. Anthony G. (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya) |
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Agweyu, Ambrose (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya) |
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Warimwe, George M. (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya) |
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Nyagwange, James (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya) |
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Distributor: |
Harvard Dataverse |
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Access Authority: |
Nyagwange, James |
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Access Authority: |
The Data Governance Committee |
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Depositor: |
Nyagwange, James |
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Date of Deposit: |
2023-08-10 |
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Holdings Information: |
https://doi.org/10.7910/DVN/FOYVMT |
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Study Scope |
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Keywords: |
Medicine, Health and Life Sciences, SARS-CoV-2, Immunoassay, Immunoglobulin G, Serology |
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Abstract: |
<p>This is a replication dataset for the manuscript titled "<a href="">Comparative performance of the InBios SCoV-2 DetectTM IgG ELISA and the in-house KWTRP ELISA in detecting SARS-CoV-2 spike IgG antibodies in Kenyan populations</a>." <p>The SARS-CoV-2 seroprevalence estimates have been carried out by institutions under the Kenya Multi-Site Sero-surveillance (KEMIS) collaboration using both the InBios SCoV-2 DetectTM IgG ELISA and in house KWTRP ELISA. For the comparability of data collected using both tests by KEMIS participating sites, we conducted a direct comparison of these assays. We directly used pre-pandemic serum/plasma collected in 2018 from 454 blood donors and 173 malaria cross-sectional survey participants designated gold standard negatives. As gold standard positives, we assayed serum/plasma from 159 SARS-CoV-2 PCR-positive patients and 166 vaccination-confirmed participants.We obtained ODs(Optical density) from the samples' reactivity to SARS-CoV-2 antigen on both ELISA assays. We then expressed the OD into a ratio using the control samples. The ratios from both assays were then used to determine specificity, sensitivity, and prevalence. Pairwise comparisons between the InBios and KWTRP was done and assays’ reproducibility was assesed by examining the raw ODs and coefficient of variation (CV) for the negative, positive and cut-off controls. </p> |
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Methodology and Processing |
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Sources Statement |
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Data Access |
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Other Study Description Materials |
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Label: |
BKutima_DATASET_Codebook_31072023.pdf |
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Notes: |
application/pdf |
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Label: |
BKutima_DATASET_Readme_31072023.txt |
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Notes: |
text/plain |
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Label: |
datasets.zip |
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Notes: |
application/zip |
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Inbios_KWTRP_230523.do |
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Notes: |
application/x-stata-syntax |
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Inbios_KWTRP_270324.do |
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Notes: |
application/x-stata-syntax |
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InBios_KWTRP_coefficient of variation plots.R |
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Notes: |
type/x-r-syntax |
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Label: |
InBios_KWTRP_vaccinated_ELISA_21062023.pzfx |
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Notes: |
text/html |
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Label: |
KWTRP_Inbios ROC.do |
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Notes: |
application/x-stata-syntax |