|
View: |
Part 1: Document Description
|
|
Citation |
|
|---|---|
|
Title: |
Plasmodium vivax Infection Impairs Regulatory T-Cell Suppressive Function During Acute Malaria |
|
Identification Number: |
doi:10.7910/DVN/GJE2PN |
|
Distributor: |
Harvard Dataverse |
|
Date of Distribution: |
2024-03-19 |
|
Version: |
1 |
|
Bibliographic Citation: |
Costa, Pedro A C; Figueiredo Maria; Diniz, Suelen Q; Peixoto, Ana P M M; Maloy, Kevin; Teixeira-Carvalho, Andrea; Tada, Mauro; Pereira, Dhelio; Gazzinelli, Ricardo; Antonelli, Lis, 2024, "Plasmodium vivax Infection Impairs Regulatory T-Cell Suppressive Function During Acute Malaria", https://doi.org/10.7910/DVN/GJE2PN, Harvard Dataverse, V1 |
|
Citation |
|
|
Title: |
Plasmodium vivax Infection Impairs Regulatory T-Cell Suppressive Function During Acute Malaria |
|
Identification Number: |
doi:10.7910/DVN/GJE2PN |
|
Authoring Entity: |
Costa, Pedro A C (Laboratório de Biologia e Imunologia de Doenças Infecciosas e Parasitárias) |
|
Figueiredo Maria (Laboratório de Biologia e Imunologia de Doenças Infecciosas e Parasitárias; Laboratório de Imunopatologia) |
|
|
Diniz, Suelen Q (Laboratório de Biologia e Imunologia de Doenças Infecciosas e Parasitárias; Universidade Federal de Minas Gerais) |
|
|
Peixoto, Ana P M M (Laboratório de Biologia e Imunologia de Doenças Infecciosas e Parasitárias) |
|
|
Maloy, Kevin (University of Oxford) |
|
|
Teixeira-Carvalho, Andrea (Fundação Oswaldo Cruz) |
|
|
Tada, Mauro (Centro de Pesquisas em Medicina Tropical de Rondônia) |
|
|
Pereira, Dhelio (Centro de Pesquisas em Medicina Tropical de Rondônia) |
|
|
Gazzinelli, Ricardo (Laboratório de Biologia e Imunologia de Doenças Infecciosas e Parasitárias; Laboratório de Imunopatologia ; Universidade Federal de Minas Gerais) |
|
|
Antonelli, Lis (Laboratório de Biologia e Imunologia de Doenças Infecciosas e Parasitárias; Laboratório de Imunopatologia) |
|
|
Distributor: |
Harvard Dataverse |
|
Access Authority: |
Ponmattam, Jamie |
|
Depositor: |
Ponmattam, Jamie |
|
Date of Deposit: |
2024-03-18 |
|
Holdings Information: |
https://doi.org/10.7910/DVN/GJE2PN |
|
Study Scope |
|
|
Keywords: |
Medicine, Health and Life Sciences, regulatory T cells, inhibitory molecule, PD-1, Plasmodium vivax, malaria |
|
Abstract: |
Abstract The balance between pro- and antiinflammatory mechanisms is essential to limit immune-mediated pathology, and CD4+ forkhead box P3 (Foxp3+) regulatory T cells (Treg) play an important role in this process. The expression of inhibitory receptors regulates cytokine production by Plasmodium vivax-specific T cells. Our goal was to assess the induction of programmed death-1 (PD-1) and cytotoxic T-lymphocyte antigen (CTLA-4) on Treg during malaria and to evaluate their function. We found that P. vivax infection triggered an increase in circulating Treg and their expression of CTLA-4 and PD-1. Functional analysis demonstrated that Treg from malaria patients had impaired suppressive ability and PD-1+Treg displayed lower levels of Foxp3 and Helios, but had higher frequencies of T-box transcription factor+ and interferon-gamma+ cells than PD-1-Treg. Thus malaria infection alters the function of circulating Treg by triggering increased expression of PD-1 on Treg that is associated with decreased regulatory function and increased proinflammatory characteristics. |
|
Methodology and Processing |
|
|
Sources Statement |
|
|
Data Access |
|
|
Other Study Description Materials |
|
|
Related Publications |
|
|
Citation |
|
|
Title: |
Costa, P. A., Figueiredo, M. M., Diniz, S. Q., Peixoto, A. P., Maloy, K. J., Teixeira-Carvalho, A., ... & Antonelli, L. R. (2018). Plasmodium vivax infection impairs regulatory T-cell suppressive function during acute malaria. The Journal of infectious diseases, 218(8), 1314-1323. |
|
Bibliographic Citation: |
Costa, P. A., Figueiredo, M. M., Diniz, S. Q., Peixoto, A. P., Maloy, K. J., Teixeira-Carvalho, A., ... & Antonelli, L. R. (2018). Plasmodium vivax infection impairs regulatory T-cell suppressive function during acute malaria. The Journal of infectious diseases, 218(8), 1314-1323. |
|
Label: |
Data for repository ICEMR - TFH.xlsx |
|
Notes: |
application/vnd.openxmlformats-officedocument.spreadsheetml.sheet |