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Part 1: Document Description
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Citation |
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Title: |
Replication Data for: The malaria vaccine R21 is protective against intradermal but not intravenous Plasmodium falciparum sporozoites in controlled human malaria infection in Kenyan adults |
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Identification Number: |
doi:10.7910/DVN/TNHS14 |
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Distributor: |
Harvard Dataverse |
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Date of Distribution: |
2024-07-29 |
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Version: |
3 |
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Bibliographic Citation: |
Kapulu, Melissa C.; Orenge, Francesca; Kimani,Domtila; Kibwana, Elizabeth; Kibet Hillary; Mutahi, Mary; Datoo, Mehreen S.; Bellamy, Duncan; Musembi, Janet; Ngoto, Omar; Rashid, Hamisi; Akinyi, Stellamaris; Mwatasa, Mwaganyuma; Nyamako, Lydia; Keter, Kelvias; Gatheru, Rose; Mutiso, Agnes; Musyoki, Jennifer; Mwacharo, Jedidah; Abebe, Yonas; James, Eric J.; Billingsley, Peter F.; Ngetsa, Caroline; Mosobo, Moses; Makale, Johnstone; Tawa, Brian; Wamae, Kevin; Ochola-Oyier, Lynette I.; Wambua, Juliana; Lawrie, Alison; Ramos-Lopez, Fernando; Roberts, Rachel; Richie, Thomas L.; Sim, B. Kim Lee; Hoffman, Stephen L.; Ewer, Katie J.; Hill, Adrian V. S.; Hamaluba, Mainga.; Bejon, Philip, 2024, "Replication Data for: The malaria vaccine R21 is protective against intradermal but not intravenous Plasmodium falciparum sporozoites in controlled human malaria infection in Kenyan adults", https://doi.org/10.7910/DVN/TNHS14, Harvard Dataverse, V3, UNF:6:uSl7BVIrsuW6q3SVxM0ARA== [fileUNF] |
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Citation |
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Title: |
Replication Data for: The malaria vaccine R21 is protective against intradermal but not intravenous Plasmodium falciparum sporozoites in controlled human malaria infection in Kenyan adults |
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Identification Number: |
doi:10.7910/DVN/TNHS14 |
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Authoring Entity: |
Kapulu, Melissa C. (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya) |
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Orenge, Francesca (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya) |
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Kimani,Domtila (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya) |
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Kibwana, Elizabeth (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya) |
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Kibet Hillary (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya) |
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Mutahi, Mary (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya) |
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Datoo, Mehreen S. (Jenner Institute, University of Oxford, United Kingdom) |
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Bellamy, Duncan (Jenner Institute, University of Oxford, United Kingdom) |
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Musembi, Janet (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya) |
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Ngoto, Omar (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya) |
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Rashid, Hamisi (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya) |
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Akinyi, Stellamaris (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya) |
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Mwatasa, Mwaganyuma (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya) |
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Nyamako, Lydia (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya) |
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Keter, Kelvias (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya) |
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Gatheru, Rose (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya) |
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Mutiso, Agnes (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya) |
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Musyoki, Jennifer (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya) |
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Mwacharo, Jedidah (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya) |
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Abebe, Yonas (Sanaria Inc., Rockville, MD, USA) |
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James, Eric J. (Sanaria Inc., Rockville, MD, USA) |
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Billingsley, Peter F. (Sanaria Inc., Rockville, MD, USA) |
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Ngetsa, Caroline (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya) |
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Mosobo, Moses (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya) |
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Makale, Johnstone (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya) |
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Tawa, Brian (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya) |
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Wamae, Kevin (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya) |
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Ochola-Oyier, Lynette I. (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya) |
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Wambua, Juliana (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya) |
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Lawrie, Alison (Jenner Institute, University of Oxford, United Kingdom) |
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Ramos-Lopez, Fernando (Jenner Institute, University of Oxford, United Kingdom) |
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Roberts, Rachel (Jenner Institute, University of Oxford, United Kingdom) |
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Richie, Thomas L. (Sanaria Inc., Rockville, MD, USA) |
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Sim, B. Kim Lee (Sanaria Inc., Rockville, MD, USA) |
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Hoffman, Stephen L. (Sanaria Inc., Rockville, MD, USA) |
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Ewer, Katie J. (Jenner Institute, University of Oxford, United Kingdom) |
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Hill, Adrian V. S. (Jenner Institute, University of Oxford, United Kingdom) |
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Hamaluba, Mainga. (Jenner Institute, University of Oxford, United Kingdom) |
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Bejon, Philip (Jenner Institute, University of Oxford, United Kingdom) |
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Distributor: |
Harvard Dataverse |
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Access Authority: |
Kapulu, Melissa C. |
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Access Authority: |
The Data Governance Committee |
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Depositor: |
Kapulu, Melissa C. |
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Date of Deposit: |
2024-07-19 |
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Holdings Information: |
https://doi.org/10.7910/DVN/TNHS14 |
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Study Scope |
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Keywords: |
Medicine, Health and Life Sciences |
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Abstract: |
<p>This is a replication dataset for the manuscript titled: "<strong><i>The malaria vaccine R21 is protective against intradermal but not intravenous Plasmodium falciparum sporozoites in controlled human malaria infection in Kenyan adults.</i></strong>"</p> <p>We undertook controlled human malaria infections in volunteers vaccinated with the PfCSP-based vaccine R21/Matrix-M, using either intradermal injection (ID) or direct venous inoculation (DVI) of P. falciparum sporozoites (PfSPZ Challenge).</p> <p>Data package contains: <li>Elisa data - calculation of levels of anti-whole schizont antibody (3D7 strain) for comparison amongst the R21/Matrix M ID, R21/Matrix-M DVI, Control ID and control DVI groups</li> <li>PCR data - quantification the malaria parasites for comparison amongst the R21/Matrix M ID, R21/Matrix-M DVI, Control ID and control DVI groups.</li> <li>safety data - contains safety blood variables, their levels and tests.</li> <li>AE data - contains unsolicited Adverse Events.</li> </p> |
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Kind of Data: |
Restricted Access |
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Notes: |
<p><strong>Data Access: </strong>Restricted</p> <p>Access to these data requires submission of a formal request for consideration by our Data Governance Committee. </p> <strong>How to request</strong> <ol> <li>Download and complete the <a href="https://kemri-wellcome.org/zp-content/uploads/2021/02/KWTRP_Dataverse_Data_Request_Form_2019.docx"><strong>data request form</strong></a></li> <li> Email completed data request form to the Data Governance Committee at <a href="mailto:dgc@kemri-wellcome.org?cc=lmwango@kemri-wellcome.org?Subject=Data%20Access%20Request"><strong>dgc@kemri-wellcome.org</strong></a> </li> </ol> |
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Methodology and Processing |
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Sources Statement |
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Data Access |
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Notes: |
Access to these data requires submission of a formal request for consideration by our Data Governance Committee. Please download and complete the <a href="https://kemri-wellcome.org/zp-content/uploads/2021/02/KWTRP_Dataverse_Data_Request_Form_2019.docx"><strong>data request form</strong></a> and send to the Data Governance Committee at <a href="mailto:dgc@kemri-wellcome.org?Subject=Data%20Access%20Request"><strong>dgc@kemri-wellcome.org</strong></a> |
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Other Study Description Materials |
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Label: |
Analysis code.zip |
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Notes: |
application/zip |
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Label: |
ICF_CRFs.zip |
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Notes: |
application/zip |
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Label: |
R21_data_csv.zip |
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Notes: |
application/zip |
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Label: |
R21_data_stata.zip |
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Notes: |
application/zip |
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Label: |
R21_Malaria_Vaccine_MKapulu_Data Dictionary.pdf |
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Notes: |
application/pdf |
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Label: |
R21_Malaria_Vaccine_MKapulu_Data Dictionary.xlsx |
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Notes: |
application/vnd.openxmlformats-officedocument.spreadsheetml.sheet |
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Label: |
VAC074 R21-CHMI Protocol Version 1.5 dated 6Apr2022.pdf |
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Notes: |
application/pdf |