Immune cells and checkpoints in pancreatic adenocarcinoma: association with clinical and pathological aspects. (doi:10.7910/DVN/UJQ7ZW)

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Part 1: Document Description
Part 2: Study Description
Part 3: Data Files Description
Part 4: Variable Description
Part 5: Other Study-Related Materials
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Document Description

Citation

Title:

Immune cells and checkpoints in pancreatic adenocarcinoma: association with clinical and pathological aspects.

Identification Number:

doi:10.7910/DVN/UJQ7ZW

Distributor:

Harvard Dataverse

Date of Distribution:

2022-08-09

Version:

Bibliographic Citation:

de Figueiredo Barbosa, Lucas, 2022, "Immune cells and checkpoints in pancreatic adenocarcinoma: association with clinical and pathological aspects.", https://doi.org/10.7910/DVN/UJQ7ZW, Harvard Dataverse, V4, UNF:6:5EdrkK7TxzdJdDIcurOFAw== [fileUNF]

Study Description

Citation

Title:

Immune cells and checkpoints in pancreatic adenocarcinoma: association with clinical and pathological aspects.

Identification Number:

doi:10.7910/DVN/UJQ7ZW

Authoring Entity:

de Figueiredo Barbosa, Lucas

Distributor:

Harvard Dataverse

Access Authority:

de Figueiredo Barbosa, Lucas

Depositor:

de Figueiredo Barbosa, Lucas

Date of Deposit:

2022-07-12

Holdings Information:

https://doi.org/10.7910/DVN/UJQ7ZW

Study Scope

Keywords:

Medicine, Health and Life Sciences

Abstract:

This research is about the inflamatory aspects that occurs in pancreatic adenocarcinomas (regarding CD4, CD8, FOXP3 and CD163 cells; PD-L1, PD-L2 and HLA-G aspects). Main author: MD, PhD Maria Auxiliadora de Paula Carneiro Cysneiros.

Methodology and Processing

Sources Statement

Data Access

Other Study Description Materials

File Description--f10224721

File: DATA - FINAL.tab

Number of cases: 70
No. of variables per record: 35
Type of File: text/tab-separated-values

Notes:

UNF:6:5EdrkK7TxzdJdDIcurOFAw==

Variable Description

List of Variables:

SAMPLENUMBER - SAMPLE NUMBER
GROUP - GROUP
AGE - AGE
SEX - SEX
ALCOHOL - ALCOHOL
SMOKING - SMOKING
PANCREATIC_BACKGROUND - PANCREATIC BACKGROUND
PANCREATIC_BACKGROUND_TYPE - PANCREATIC BACKGROUND TYPE
FAMILIAL_PANCREATIC_CA_BACKGROUND - FAMILIAL PANCREATIC CA BACKGROUND
DIAGN_DT - DIAGNOSIS DATE
WHIPPLE_DT - WHIPPLE DATE
DEATH - DEATH
LASTEVENT_DT - DATE OF DEATH OR LAST DAY (CENSORED)
SURVIVAL_DAYS - SURVIVAL (DAYS)
SURGICAL_COMPLICATION - SURGICAL COMPLICATION
HISTOLOGIC_GRADE - HISTOLOGIC GRADE
T_STAGING - T STAGING
T_STAGING_STAT - T STAGING - STATISTICS
N_DICOTOMIC_STAGING - N DICHOTOMOUS
N_STAGING - N STAGING
M_STAGING - M STAGING
AJCC_GROUP - AJCC GROUP
PERINEURAL_INVASION - PERINEURAL INVASION
TUMORAL_SIZE - TUMORAL SIZE
CD4 - CD4
CD8 - CD8
CD163 - CD163
FOXP3 - FOXP3
HLAG - HLA-G
PDL1 - PD-L1
PDL2 - PD-L2
HLAG_DIC - HLA G - DICHOTOMOUS
PDL1_DIC - PDL1 DICHOTMOUS
PDL2_DIC - PDL2 DICHOTMOUS
AJCC_GROUP_STAT - AJCC GROUP - STATISTICS

Variables

SAMPLE NUMBER

f10224721 Location:

Variable Format: character

Notes: UNF:6:X0YsHyn4JjZXqB/wxuUX4Q==

GROUP

f10224721 Location:

Value	Label	Frequency	Text
2.	Inoperable group	27
1.	Operated group	43

Summary Statistics: Valid 70.0; Min. 1.0; Max. 2.0; StDev 0.49027815656773166; Mean 1.3857142857142855;

Variable Format: numeric

Notes: UNF:6:WGIxQhAdF99Obb/WZEZhzQ==

AGE

f10224721 Location:

Summary Statistics: Mean 62.22857142857143; Valid 70.0; Min. 35.0; StDev 9.830699370010235; Max. 79.0

Variable Format: numeric

Notes: UNF:6:Ze7H9pOHPDFLaiKVBO0lxA==

SEX

f10224721 Location:

Value	Label	Frequency	Text
2.	Female	29
1.	Male	41

Summary Statistics: Max. 2.0; Min. 1.0; StDev 0.49615498814052905; Mean 1.4142857142857141; Valid 70.0

Variable Format: numeric

Notes: UNF:6:d231x+y5m6j0pq3YXrRXKg==

ALCOHOL

f10224721 Location:

Value	Label	Frequency
2.	No	34
1.	Yes	26
9.	Ignored	9

Summary Statistics: StDev 2.56434666685142; Min. 1.0; Mean 2.536231884057971; Max. 9.0; Valid 69.0;

Variable Format: numeric

Notes: UNF:6:M6LclzWJ9UVsrORAcUzIcw==

SMOKING

f10224721 Location:

Value	Label	Frequency
2.	No	24
1.	Yes	36
9.	Ignored	10

Summary Statistics: Min. 1.0; Valid 70.0; Mean 2.4857142857142858; StDev 2.717324222774496; Max. 9.0;

Variable Format: numeric

Notes: UNF:6:n7Wb7D4blj+KNTJ4pMVJVw==

PANCREATIC BACKGROUND

f10224721 Location:

Value	Label	Frequency
9.	Ignored	11
1.	Yes	21
2.	No	38

Summary Statistics: Valid 70.0; StDev 2.7325202042558923; Min. 1.0; Max. 9.0; Mean 2.8

Variable Format: numeric

Notes: UNF:6:nMS8wws6PcBt+i0Rtmm2XA==

PANCREATIC BACKGROUND TYPE

f10224721 Location:

Value	Label	Frequency
8.	Others	0
9.	Ignored	0
3.	Chronic pancreatitis	2
1.	Diabetes	17
4.	Diabetes + acute pancreatitis	0
2.	Acute pancreatitis	1
5.	Diabetes + chronic pancreatitis	1

Summary Statistics: Max. 5.0; Valid 21.0; Mean 1.4285714285714284; StDev 1.0281745265969477; Min. 1.0;

Variable Format: numeric

Notes: UNF:6:Il94m+H7fR8urI6vMaFcOw==

FAMILIAL PANCREATIC CA BACKGROUND

f10224721 Location:

Summary Statistics: Min. 1.0; Mean 3.3571428571428568; Valid 70.0; Max. 9.0; StDev 2.849030927468648;

Variable Format: numeric

Notes: UNF:6:t67A74B/8hZxeW8mhfR26g==

DIAGNOSIS DATE

f10224721 Location:

Variable Format: character

Notes: UNF:6:fgPNC8qEfmdaW/Fim2L1WA==

WHIPPLE DATE

f10224721 Location:

Variable Format: character

Notes: UNF:6:0L2u/nobtdeG7fca5lMMYA==

DEATH

f10224721 Location:

Value	Label	Frequency	Text
1.	Death event	59
3.	Censored data	11

Summary Statistics: Mean 1.3142857142857143; StDev 0.7331262647612734; Max. 3.0; Min. 1.0; Valid 70.0;

Variable Format: numeric

Notes: UNF:6:oJFCBbJJ8FXHnHth47GPHg==

DATE OF DEATH OR LAST DAY (CENSORED)

f10224721 Location:

Variable Format: character

Notes: UNF:6:SJMTadR29wOYa22wWqQUqg==

SURVIVAL (DAYS)

f10224721 Location:

Summary Statistics: Valid 70.0; Max. 2165.0; StDev 408.5595321423156; Mean 334.5; Min. 2.0

Variable Format: numeric

Notes: UNF:6:tW/Ylc1iGiVmg2gMuTd2Gw==

SURGICAL COMPLICATION

f10224721 Location:

Value	Label	Frequency	Text
1.	Yes	14
0.	No	56

Summary Statistics: Mean 0.19999999999999993; Max. 1.0; StDev 0.40288812414826736; Valid 70.0; Min. 0.0

Variable Format: numeric

Notes: UNF:6:GY96dzdhme22TQU7d4c7sQ==

HISTOLOGIC GRADE

f10224721 Location:

Value	Label	Frequency
3.	Grade 3	6
2.	Grade 2	49
1.	Grade 1	11

Summary Statistics: Mean 1.9242424242424243; Min. 1.0; StDev 0.505678707986559; Valid 66.0; Max. 3.0

Variable Format: numeric

Notes: UNF:6:wK4WM/AaSMX3lELWec3WTA==

T STAGING

f10224721 Location:

Value	Label	Frequency
6.	T3	9
1.	T1	0
5.	T2	22
4.	T1c	10
2.	T1a	1
7.	T4	27
3.	T1b	0

Summary Statistics: Valid 69.0; Max. 7.0; Mean 5.724637681159419; StDev 1.2112713055373159; Min. 2.0;

Variable Format: numeric

Notes: UNF:6:5Jl2/hWZ6cJbLqAc+duPJA==

T STAGING - STATISTICS

f10224721 Location:

Value	Label	Frequency
1.	T1	11
7.	T4	27
5.	T2	22
6.	T3	9

Summary Statistics: Min. 1.0; StDev 2.057154359296116; Mean 5.275362318840581; Max. 7.0; Valid 69.0

Variable Format: numeric

Notes: UNF:6:xS6IRBGrDrsVOOp1tEjN1w==

N DICHOTOMOUS

f10224721 Location:

Value	Label	Frequency	Text
1.	Positive	13
0.	Negative	29

Summary Statistics: Max. 1.0; Valid 42.0; Mean 0.30952380952380953; StDev 0.4679011380933328; Min. 0.0

Variable Format: numeric

Notes: UNF:6:8N29AUh6+4LWRc3qGdD2hw==

N STAGING

f10224721 Location:

Value	Label	Frequency
2.	N2	4
1.	N1	9
0.	N0	29

Summary Statistics: StDev 0.664776647234602; Mean 0.4047619047619048; Min. 0.0; Valid 42.0; Max. 2.0

Variable Format: numeric

Notes: UNF:6:Bv8o3aRfGyuC+ZIUeWaWlg==

M STAGING

f10224721 Location:

Value	Label	Frequency	Text
0.	M0	62
1.	M1	7

Summary Statistics: Max. 1.0; Mean 0.10144927536231885; Valid 69.0; Min. 0.0; StDev 0.3041346226799943

Variable Format: numeric

Notes: UNF:6:+KF2f6ZdIsuRp0ZxQsKSFw==

AJCC GROUP

f10224721 Location:

Value	Label	Frequency
3.	IB	14
0.	0	0
6.	IV	7
2.	IIA	5
1.	IA	8
5.	III	26
4.	IIB	8

Summary Statistics: Valid 68.0; Min. 1.0; StDev 1.5407830124594954; Mean 3.88235294117647; Max. 6.0;

Variable Format: numeric

Notes: UNF:6:1FJHNhbclSurVjTNN/qeXw==

PERINEURAL INVASION

f10224721 Location:

Value	Label	Frequency	Text
2.	Not detected	7
1.	Detected	18

Summary Statistics: StDev 0.45825756949558394; Valid 25.0; Mean 1.28; Max. 2.0; Min. 1.0;

Variable Format: numeric

Notes: UNF:6:o46B/LgxB0QcOnEhMcc8DQ==

TUMORAL SIZE

f10224721 Location:

Summary Statistics: Mean 3.257142857142857; Min. 0.2; Max. 7.0; StDev 1.3884792272338573; Valid 42.0;

Variable Format: numeric

Notes: UNF:6:FF0ok9lzIwres9wyw0xJDA==

CD4

f10224721 Location:

Summary Statistics: Mean 219.04285714285712; Min. 42.0; Max. 627.0; StDev 121.96642870416785; Valid 70.0;

Variable Format: numeric

Notes: UNF:6:8MP7KOSNMrHvbXI5KT8psg==

CD8

f10224721 Location:

Summary Statistics: Mean 401.0; Max. 859.0; Valid 70.0; Min. 45.0; StDev 178.1948127874317

Variable Format: numeric

Notes: UNF:6:LA4jYEQUXXsupGg84jVMrA==

CD163

f10224721 Location:

Summary Statistics: Mean 383.6857142857143; Valid 70.0; Min. 139.0; Max. 722.0; StDev 135.3820726317267

Variable Format: numeric

Notes: UNF:6:i15DHcW8pRb6QUSIhSK2Pw==

FOXP3

f10224721 Location:

Summary Statistics: StDev 46.36680873621725; Max. 244.0; Valid 70.0; Mean 50.78571428571429; Min. 1.0;

Variable Format: numeric

Notes: UNF:6:cdDFotoOhuBIwxs7NnKQig==

HLA-G

f10224721 Location:

Summary Statistics: Mean 62.8; Max. 99.0; Valid 70.0; StDev 29.438513667583848; Min. 0.0;

Variable Format: numeric

Notes: UNF:6:43v2XBdytcV+fUtfq7oWVg==

PD-L1

f10224721 Location:

Summary Statistics: Valid 70.0; Min. 0.0; Mean 7.485714285714285; Max. 60.0; StDev 13.17523242612447

Variable Format: numeric

Notes: UNF:6:w+gstDP2T8eL2lclY8+ZqQ==

PD-L2

f10224721 Location:

Summary Statistics: Valid 70.0; Min. 0.0; Mean 52.142857142857146; Max. 95.0; StDev 28.40661574009447

Variable Format: numeric

Notes: UNF:6:dXrkiSPDi55IdYRujQObjg==

HLA G - DICHOTOMOUS

f10224721 Location:

Value	Label	Frequency	Text
1.	Positive	32
0.	Negative	38

Summary Statistics: StDev 0.501756748204277; Max. 1.0; Valid 70.0; Mean 0.4571428571428572; Min. 0.0

Variable Format: numeric

Notes: UNF:6:20/xAKLEWbxkGFTFcGyqdQ==

PDL1 DICHOTMOUS

f10224721 Location:

Value	Label	Frequency	Text
0.	Negative	48
1.	Positive	22

Summary Statistics: Max. 1.0; Mean 0.31428571428571433; StDev 0.4675826561931813; Min. 0.0; Valid 70.0;

Variable Format: numeric

Notes: UNF:6:5nWSmxCtkfeQz6sv1eBnXg==

PDL2 DICHOTMOUS

f10224721 Location:

Value	Label	Frequency	Text
0.	Negative	11
1.	Positive	59

Summary Statistics: Valid 70.0; Max. 1.0; Mean 0.8428571428571429; StDev 0.3665631323806366; Min. 0.0

Variable Format: numeric

Notes: UNF:6:0Hidddy2nplT4uLidwoMeA==

AJCC GROUP - STATISTICS

f10224721 Location:

Value	Label	Frequency
6.	IV	7
2.	II	13
5.	III	26
1.	I	22

Summary Statistics: Max. 6.0; Min. 1.0; Valid 68.0; Mean 3.2352941176470598; StDev 1.9859029079904382

Variable Format: numeric

Notes: UNF:6:dxQFcO+Kmfe+VOUTzENkoQ==

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