Replication data for: Characterization of naturally acquired immunity to a panel of antigens expressed in mature P. falciparum gametocytes (doi:10.7910/DVN/WL8TRW)

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Replication data for: Characterization of naturally acquired immunity to a panel of antigens expressed in mature P. falciparum gametocytes

doi:10.7910/DVN/WL8TRW

Harvard Dataverse

2021-09-01

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Muthui, Michelle K.; Takashima, Eizo; Omondi, Brian R.; Kinya, Christine; Muasya, William I.; Nagaoka, Hikaru; Mwai, Kennedy; Orindi, Benedict; Wambua, Juliana; Bousema, Teun; Drakeley, Chris; Blagborough, Andrew M.; Marsh, Kevin; Bejon, Philip; Kapulu, Melissa C., 2021, "Replication data for: Characterization of naturally acquired immunity to a panel of antigens expressed in mature P. falciparum gametocytes", https://doi.org/10.7910/DVN/WL8TRW, Harvard Dataverse, V1, UNF:6:nsb4jqYIxaNgnqdR30WSCw== [fileUNF]

Replication data for: Characterization of naturally acquired immunity to a panel of antigens expressed in mature P. falciparum gametocytes

doi:10.7910/DVN/WL8TRW

Muthui, Michelle K. (KEMRI Wellcome Trust Research Programme)

Takashima, Eizo (Division of Malaria Research, Proteo-Science Centre, Ehime University, Matsuyama, Japan)

Omondi, Brian R. (KEMRI Wellcome Trust Research Programme)

Kinya, Christine (KEMRI Wellcome Trust Research Programme)

Muasya, William I. (KEMRI Wellcome Trust Research Programme)

Nagaoka, Hikaru (Division of Malaria Research, Proteo-Science Centre, Ehime University, Matsuyama, Japan)

Mwai, Kennedy (KEMRI Wellcome Trust Research Programme)

Orindi, Benedict (KEMRI Wellcome Trust Research Programme)

Wambua, Juliana (KEMRI Wellcome Trust Research Programme)

Bousema, Teun (Department of Medical Microbiology, Radboud University Medical Centre, Nijmegen, The Netherlands)

Drakeley, Chris (Department of Biology of Infection, London School of Hygiene and Tropical Medicine, Faculty of Infectious and Tropical Diseases, London, UK)

Blagborough, Andrew M. (Division of Microbiology and Parasitology, Department of Pathology, Cambridge University, Tennis Court Road, Cambridge, CB2 1QP, UK)

Marsh, Kevin (Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK)

Bejon, Philip (KEMRI Wellcome Trust Research Programme)

Kapulu, Melissa C. (KEMRI Wellcome Trust Research Programme)

Harvard Dataverse

Data Governance Office

Muthui, Michelle K.

Kapulu, Melissa C.

Wafula, James

2021-09-01

https://doi.org/10.7910/DVN/WL8TRW

Medicine, Health and Life Sciences

We used data from a longitudinally monitored cohort of children and adults from Kilifi county located along the Kenyan coast collected between 1998-2016 to describe the factors associated with the acquisition of antibody responses to antigens expressed on the surface of mature gametocytes. A panel of candidate gametocyte antigens were identified and produced as recombinant protein for this analysis. The datasets comprise data from cross-sectional surveys carried out to assess parasite prevalence. The datasets were used to carry out analyses aimed at describing the seroprevalence of antibodies to the candidate antigens, and assess the factors associated with antibody responses to these antigens. The overall aim of the analyses was to improve our understanding of immunity to the transmissible stages of the malaria parasite.

Data that support the findings of this manuscript are available through the KEMRI-Wellcome Trust Research Programme Data Governance Committee if the use of the data is complaint with the consent provided by the participants. Details of the criteria can be found in the KEMRI-Wellcome data sharing guidelines <a href="https://kemri-wellcome.org/about-us/#ChildVerticalTab_15">https://kemri-wellcome.org/about-us/#ChildVerticalTab_15</a>. Requests for the data can be made to the Data Governance Committee through the corresponding author.

Publications based on this data collection should acknowledge this source by means of bibliographic citation. To cite this dataset, use the following citation: "Muthui, Michelle K.; Takashima, Eizo; Omondi, Brian R.; Kinya, Christine; Muasya, William I.; Nagaoka, Hikaru; Mwai, Kennedy; Orindi, Benedict; Wambua, Juliana; Bousema, Teun; Drakeley, Chris; Blagborough, Andrew M.; Marsh, Kevin; Bejon, Philip; Kapulu, Melissa C., 2021, "Kilifi Malaria Longitudinal Cohort cross-sectional survey and weekly-follow-up surveillance data for the estimation of parasite prevalence and factors associated with gametocyte carriage.", https://doi.org/10.7910/DVN/WL8TRW, Harvard Dataverse, V1"

This data is made available under the Creative Commons Attribution 4.0 International (CC BY 4.0) - https://creativecommons.org/licenses/by/4.0/legalcode

The data includes information of a personal nature and its use can only be permitted under the conditions provided by the research participants and approved by the Kenya Medical Research Institute Ethics Review Committee. Details of the data access criteria can be found in the KEMRI-Wellcome data sharing guidelines (https://kemri-wellcome.org/about-us/#ChildVerticalTab_15). Requests for the data can be made to the Data Governance Committee through the corresponding author.

• Number of cases: 216

• No. of variables per record: 41

• Type of File: text/tab-separated-values

UNF:6:TTwJhndrYncdD9eEs69hAw==

• Number of cases: 272

• No. of variables per record: 41

• Type of File: text/tab-separated-values

UNF:6:aH5ZC1sgmarGtz3eS4sAYQ==

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AFIRM_parasitaemia.R

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AFIRM_seroprevalence.R

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Breadth_analysis.R

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KMLC_parasitaemia.R

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KWTRP_DATA_CODEBOOK_MMuthui.docx

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MMuthui_ReadMe.txt

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Models - AFIRM.R

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Models AFIRM_patentsubpatent.R

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