Replication Data for: The impact of rickets on growth and morbidity during recovery among children with complicated severe acute malnutrition in Kenya: A cohort study (doi:10.7910/DVN/XG8KDS)

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Replication Data for: The impact of rickets on growth and morbidity during recovery among children with complicated severe acute malnutrition in Kenya: A cohort study

doi:10.7910/DVN/XG8KDS

Harvard Dataverse

2019-05-22

1

Ngari, Moses M.; Berkley, James A., 2019, "Replication Data for: The impact of rickets on growth and morbidity during recovery among children with complicated severe acute malnutrition in Kenya: A cohort study", https://doi.org/10.7910/DVN/XG8KDS, Harvard Dataverse, V1, UNF:6:wpGRAuzOUwVGjzrV8JoAzw== [fileUNF]

Replication Data for: The impact of rickets on growth and morbidity during recovery among children with complicated severe acute malnutrition in Kenya: A cohort study

doi:10.7910/DVN/XG8KDS

Ngari, Moses M. (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya)

Berkley, James A. (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya)

WT083579MA

OPP1131320

Harvard Dataverse

Ngari, Moses M.

Ngari, Moses M.

2019-05-15

https://doi.org/10.7910/DVN/XG8KDS

Medicine, Health and Life Sciences, children, mortality, rickets, severe acute malnutrition, severe pneumonia

<p>This was seconday analysis of data from Daily co-trimoxazole prophylaxis to prevent mortality in children with complicated severe acute malnutrition: a multicentre, double-blind, randomized placebo-controlled trial ((ClinicalTrials.gov ID <a href="https://clinicaltrials.gov/ct2/show/NCT00934492">NCT00934492</a>). </p> <p>The aim of this secondary analysis was to investigate the associations of clinically diagnosed rickets at study enrolment with anthropometric recovery and life‐threatening events during 1 year following inpatient treatment for complicated SAM. The main outcomes were episodes of life‐threatening events and anthropometry (MUAC, weight, length/height, and head circumference) during the course of the primary trial of 12 months. Life‐threatening events were defined as all‐cause mortality or all hospital readmissions. Study participants data were collected at baseline and during one year follow-up.</p>

Access to datasets is restricted as it contains sensitive information on participants. Accompanying documentation is available under open access. For more detailed information beyond the metadata and documentation provided, there is a process of managed access requiring submission of a request form for consideration by our Data Governance Committee <a href="http://kemri-wellcome.org/about-us/#ChildVerticalTab_15">( http://kemri-wellcome.org/about-us/#ChildVerticalTab_15 )</a>

Publications based on this data collection should acknowledge this source by means of bibliographic citation. To ensure that such source attributions are captured for bibliographic utilities, citations must appear in footnotes or in the reference section of publications. The bibliographic citation for this data collection is: "Ngari, Moses M.; Berkley, James A., 2019, "Replication Data for: The impact of rickets on growth and morbidity during recovery among children with complicated severe acute malnutrition in Kenya: A cohort study", https://doi.org/10.7910/DVN/XG8KDS, Harvard Dataverse, V1"

This data is made available under the Creative Commons Attribution 4.0 International (CC BY 4.0) - https://creativecommons.org/licenses/by/4.0/legalcode. Publications based on these data should acknowledge this source by means of bibliographic citations. For more information on these data, please contact the Principal Investigator, author(s) OR the data governance office via this email address: dgc@kemri-wellcome.org

Access to the dataset is restricted as it contains sensitive information on participants. Accompanying documentation is available under open access. For more detailed information beyond the metadata and documentation provided, there is a process of managed access requiring submission of a request form for consideration by our Data Governance Committee <a href="http://kemri-wellcome.org/about-us/#ChildVerticalTab_15">( http://kemri-wellcome.org/about-us/#ChildVerticalTab_15 )</a>.

Berkley, James A.; Ngari, Moses M., 2019, "Daily co-trimoxazole prophylaxis to prevent mortality in children with complicated severe acute malnutrition", https://doi.org/10.7910/DVN/PS2XH1, Harvard Dataverse, V1

Ngari, M.M., Thitiri, J., Mwalekwa, L., Timbwa, M., Iversen, P.O., Fegan, G.W. and Berkley, J.A., 2018. The impact of rickets on growth and morbidity during recovery among children with complicated severe acute malnutrition in Kenya: A cohort study. Maternal & child nutrition, 14(2), p.e12569.

10.1111/mcn.12569

Ngari, M.M., Thitiri, J., Mwalekwa, L., Timbwa, M., Iversen, P.O., Fegan, G.W. and Berkley, J.A., 2018. The impact of rickets on growth and morbidity during recovery among children with complicated severe acute malnutrition in Kenya: A cohort study. Maternal & child nutrition, 14(2), p.e12569.

<p>Berkley, J.A., Ngari, M., Thitiri, J., Mwalekwa, L., Timbwa, M., Hamid, F., Ali, R., Shangala, J., Mturi, N., Jones, K.D. and Alphan, H., 2016. Daily co-trimoxazole prophylaxis to prevent mortality in children with complicated severe acute malnutrition: a multicentre, double-blind, randomized placebo-controlled trial. The Lancet Global Health, 4(7), pp.e464-e473.

10.1016/S2214-109X(16)30096-1

<p>Berkley, J.A., Ngari, M., Thitiri, J., Mwalekwa, L., Timbwa, M., Hamid, F., Ali, R., Shangala, J., Mturi, N., Jones, K.D. and Alphan, H., 2016. Daily co-trimoxazole prophylaxis to prevent mortality in children with complicated severe acute malnutrition: a multicentre, double-blind, randomized placebo-controlled trial. The Lancet Global Health, 4(7), pp.e464-e473.

• Number of cases: 1778

• No. of variables per record: 358

• Type of File: text/tab-separated-values

UNF:6:gZbc+QtzyVvmY45FdylkEg==

This file contains baseline, follow-up and study conclusion clinical, intervention adherence, follow-up dates and anthropometry. (STATA Version 13.1)

• Number of cases: 461

• No. of variables per record: 6

• Type of File: text/tab-separated-values

UNF:6:5J1aNfKc0kMMnm7xcBgjBg==

This file contains all all hospital re-admission during follow-up for diarrhoea only. ( STATA Version 13.1)

• Number of cases: 1778

• No. of variables per record: 93

• Type of File: text/tab-separated-values

UNF:6:iIimTNMxrTwKnALkKV27bw==

This file contains all the study anthropometric measurements (Weight, Height, MUAC, Head Circumference, weight-for-age, height-for-age, weight-for-length z-scores) used for growth analysis ( STATA Version 13.1)

• Number of cases: 999

• No. of variables per record: 8

• Type of File: text/tab-separated-values

UNF:6:LgMc6XYvDHcYd9hDX5+zfQ==

This file contains all hospital re-admission during follow-up. (STATA Version 13.1)

• Number of cases: 700

• No. of variables per record: 5

• Type of File: text/tab-separated-values

UNF:6:QLUX2T5DkPu/bGb6+ovz5w==

This file contains all hospital re-admission during follow-up for Severe pneumonia only. (STATA Version 13.1)

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Baseline Factors associated with rickets.do

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This script was used to create Table 1 (Study participnats characteristics), Table 2 (factors associated with rickets) and Supplementary Table 1. (Software: STATA Version 13.1)

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CTX_data_Codebook.pdf

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Contains variable description, value labels and format. This codebook related to the Clotrimoxazole Trial data - doi:https://doi.org/10.7910/DVN/PS2XH1

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NgariMM_Rickets_Readme.txt

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File contains a brief description of the dataset, related study, methods of processing, file contents and terms of use

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Rickets_Diarrhoea.do

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This script was used to create Table 3 (diarrhoea) and Figure 1d (Software: STATA Version 13.1)

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Rickets_growth.do

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This script was used to create Table 4 (Effects of rickets on growth), Supplementary Table 3 to 4 and Supplementary Figure 1. (Software: STATA Version 13.1)

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Rickets_re_admissions.do

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This script was used to create Table 3 (All hospital readmissions) and Figure 1b (Software: STATA Version 13.1)

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Rickets_severe_pneumonia.do

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This script was used to create Table 3 (severe pneumonia) and Figure 1c (Software: STATA Version 13.1)

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Rickets_survival.do

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This script was used to create Table 3 (Mortality) and Figure 1a (Kaplan-Meier curves for mortality) (Software: STATA Version 13.1)

application/x-stata-syntax