Data for: Controlled Human Malaria Infection in Semi-Immune Kenyan Adults (CHMI-SIKA) (doi:10.7910/DVN/YPVZFV)

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Data for: Controlled Human Malaria Infection in Semi-Immune Kenyan Adults (CHMI-SIKA)

doi:10.7910/DVN/YPVZFV

Harvard Dataverse

2022-01-11

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Kapulu, Melissa C.; Otieno, Edward; Bejon, Philip, 2022, "Data for: Controlled Human Malaria Infection in Semi-Immune Kenyan Adults (CHMI-SIKA)", https://doi.org/10.7910/DVN/YPVZFV, Harvard Dataverse, V3

Data for: Controlled Human Malaria Infection in Semi-Immune Kenyan Adults (CHMI-SIKA)

doi:10.7910/DVN/YPVZFV

Kapulu, Melissa C. (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University Oxford, Oxford, UK)

Otieno, Edward (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya)

Bejon, Philip (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya; Epidemiology and Demography, KEMRI-Wellcome Trust Research Programme, Kilifi, 80108, Kenya 2 Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK)

Harvard Dataverse

Kapulu, Melissa C.

Bejon, Philip

The Data Governance Committee

Kapulu, Melissa C.

2022-01-11

https://doi.org/10.7910/DVN/YPVZFV

Medicine, Health and Life Sciences, Medicine, Health and Life Sciences

<p>Malaria remains a major public health threat despite regulatory approval of a partially effective pre-erythrocytic malaria vaccine. There is an urgent need to accelerate the development of a more effective multi-stage vaccine. Controlled human malaria infection (CHMI) has been shown to be an important tool for the assessment of the efficacy of novel malaria vaccines and drugs prior to field trials. CHMI also allows for the evaluation of immunity to malaria and parasite growth rates in vivo. This is particularly useful in individuals from endemic areas with a level of exposure and immunity to malaria. Thus CHMI in individuals with prior exposure to malaria could be a valuable tool to accelerate malaria vaccine development. In this study, the investigators aim to use CHMI in semi-immune adults to provide a comprehensive prioritization of antigens associated with blood-stage immunity for vaccine development. The investigators will comprehensively characterize immunity to malaria using >100 antigens in up to 2,000 semi-immune adults, from known areas of malaria endemicity in Kenya, then select 200 individuals with a range of different immunological profiles, and conduct CHMI studies with serial quantitative polymerase chain reaction (PCR) to measure the parasite growth rate in vivo and relate this to host immunity. </p> <p>The trial is registered at <a href="https://clinicaltrials.gov/ct2/home">ClinicalTrials.gov</a>: <a href="https://clinicaltrials.gov/ct2/show/NCT02739763">NCT02739763</a> <p>Study Protocol: <a href="https://doi.org/10.12688/wellcomeopenres.14909.2">Controlled Human Malaria Infection in Semi-Immune Kenyan Adults (CHMI-SIKA): a study protocol to investigate in vivo Plasmodium falciparum malaria parasite growth in the context of pre-existing immunity</a> </p> <p>Extended Data: <a href="https://doi.org/10.7910/DVN/XOXLJQ">Kapulu, Melissa C.; Njuguna, Patricia; Hamaluba, Mainga, 2018, "Replication Data for: Controlled Human Malaria Infection in Semi-Immune Kenyan Adults (CHMI-SIKA): a study protocol to investigate in vivo Plasmodium falciparum malaria parasite growth in the context of pre-existing immunity", https://doi.org/10.7910/DVN/XOXLJQ, Harvard Dataverse, V1</a></p>

<p><strong>Data Access: </strong>Restricted</p> <p>Access to these data requires submission of a formal request for consideration by our Data Governance Committee. </p> <strong>How to request</strong> <ol> <li>Download and complete the <a href="https://kemri-wellcome.org/zp-content/uploads/2021/02/KWTRP_Dataverse_Data_Request_Form_2019.docx"><strong>data request form</strong></a></li> <li> Email completed data request form to the Data Governance Committee at <a href="mailto:dgc@kemri-wellcome.org?cc=lmwango@kemri-wellcome.org?Subject=Data%20Access%20Request"><strong>dgc@kemri-wellcome.org</strong></a> </li> </ol> <p><strong>License: </strong><a href="https://creativecommons.org/licenses/by/4.0/legalcode">Creative Commons Attribution 4.0 International</a> <a href="https://creativecommons.org/licenses/by/4.0/legalcode"><img src="https://i.creativecommons.org/l/by/3.0/88x31.png"> </a></p>

<p>Publications based on this data collection should acknowledge this source by means of bibliographic citation.</p>

<p>This data is licensed under the <a href="https://creativecommons.org/licenses/by/4.0/legalcode">Creative Commons Attribution 4.0 International</a> <a href="https://creativecommons.org/licenses/by/4.0/legalcode"><img src="https://i.creativecommons.org/l/by/3.0/88x31.png"> </a> </p>

For access to data and more detailed information beyond the metadata and documentation provided, please send a signed data request form to [<a href="mailto:dgc@kemri-wellcome.org">dgc@kemri-wellcome.org</a> ]. <strong> <a href="https://kemri-wellcome.org/zp-content/uploads/2021/02/KWTRP_Dataverse_Data_Request_Form_2019.docx">Click to download Data Request Form</a></strong>

Kapulu, Melissa C.; Njuguna, Patricia; Hamaluba, Mainga, 2018, "Replication Data for: Controlled Human Malaria Infection in Semi-Immune Kenyan Adults (CHMI-SIKA): a study protocol to investigate in vivo Plasmodium

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