Replication Data for: A field bioassay for assessing ivermectin bio-efficacy in wild malaria (doi:10.7910/DVN/YYUKHF)

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Part 1: Document Description
Part 2: Study Description
Part 3: Data Files Description
Part 4: Variable Description
Part 5: Other Study-Related Materials
Entire Codebook

Replication Data for: A field bioassay for assessing ivermectin bio-efficacy in wild malaria

doi:10.7910/DVN/YYUKHF

Harvard Dataverse

2023-03-07

2

Ominde, Kelly M.; Kamau, Yvonne; Karisa, Jonathan; Muturi, Martha N.; Kiuru, Caroline; Wanjiku, Caroline; Babu, Lawrence; Yaah, Festus; Tuwei, Mercy; Musani, Haron; Ondieki, Zedekiah; Muriu, Simon; Mwangangi, Joseph; Maia, Marta F., 2023, "Replication Data for: A field bioassay for assessing ivermectin bio-efficacy in wild malaria", https://doi.org/10.7910/DVN/YYUKHF, Harvard Dataverse, V2, UNF:6:CFC+etNXifMwJmKNlpTWtg== [fileUNF]

Replication Data for: A field bioassay for assessing ivermectin bio-efficacy in wild malaria

doi:10.7910/DVN/YYUKHF

Ominde, Kelly M. (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya)

Kamau, Yvonne (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya)

Karisa, Jonathan (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya)

Muturi, Martha N. (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya)

Kiuru, Caroline (IS Global, Barcelona, Spain)

Wanjiku, Caroline (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya)

Babu, Lawrence (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya)

Yaah, Festus (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya)

Tuwei, Mercy (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya)

Musani, Haron (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya)

Ondieki, Zedekiah (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya)

Muriu, Simon (Pwani University, Kilifi, Kenya)

Mwangangi, Joseph (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya)

Maia, Marta F. (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya)

Harvard Dataverse

Ominde, Kelly M.

Maia, Marta F.

Ominde, Kelly M.

2023-03-06

https://doi.org/10.7910/DVN/YYUKHF

Medicine, Health and Life Sciences, Ivermectin, monitoring, vector control, bio-efficacy, Anopheles gambiae, Kenya, field bioassay, wild vectors

<p>This is a replication dataset for the manuscript titled: "<a href="">A field bioassay for assessing ivermectin bio-efficacy in wild malaria</a>."</p> <p>The files contain survival dataset for insectary cohort mosquitoes exposed to different concentrations of ivermectin and followed up for 28 days including wild mosquitoes followed up for 14 days post exposure as well. The nature of data is binnary and data was collected by recording 0 for no mortality and 1 for each individual mortality event. The goal was to determine mosquitocidal effect of ivermectin administered in sugar alone compared to blood and later administered in different mixtures of blood and sugar mixtures with an aim of developing a field friendly bioassay for assessing ivermectin bio-efficacy in wild malaria vectors. The different datasets are grouped as ivermectin spiked in sugar (glucose solution), ivermectin spiked in blood, ivermectin spiked in different mixtures of blood and glucose solution of varying ratios (Blood to sugar) 1:1, 1:2, 1:4 and 1:8. Mealsize estimation file contains dataset for individual mosquito weights (in milligrams) obtained after being fed on either: 1) blood; 2) glucose solution; 3) 1:1 blood to glucose mixture; 4) 1:2 blood to glucose mixture; 5) 1:4 blood to glucose mixture; or 6) 1:8 blood to glucose mixtures. Species ID by morphology and PCR are dataset for the wild mosquitoes identified to species complex by microscopy and at sibling species molecularly by PCR methods respectively. </p>

Open Access

<p><strong>Data Access: </strong>Open</p> <p><strong>Data Citation Requirements: </strong>All outputs based on this data collection should acknowledge this source by means of bibliographic citation</p>

• Number of cases: 872

• No. of variables per record: 5

• Type of File: text/tab-separated-values

UNF:6:59mSXcpkfSAwxif7rtUd/g==

• Number of cases: 830

• No. of variables per record: 5

• Type of File: text/tab-separated-values

UNF:6:SMstiMrUe+Cua+jIxFyAnQ==

• Number of cases: 922

• No. of variables per record: 5

• Type of File: text/tab-separated-values

UNF:6:g20x/cdqpTwZsCc5OskqbA==

• Number of cases: 598

• No. of variables per record: 5

• Type of File: text/tab-separated-values

UNF:6:Zp1DdbOVTAqU9ORrMB9E3A==

• Number of cases: 894

• No. of variables per record: 5

• Type of File: text/tab-separated-values

UNF:6:JqJzD34PosGLqeRwMOmvOg==

• Number of cases: 815

• No. of variables per record: 5

• Type of File: text/tab-separated-values

UNF:6:W5Cql0JPHKFfpuq1HLK5xw==

• Number of cases: 906

• No. of variables per record: 5

• Type of File: text/tab-separated-values

UNF:6:MrUTc9uyJX9r0Ug087+VTw==

• mosquito - mosquito
• replicate - replicate
• outcome - outcome
• time - time
• treatment - treatment
• mosquito - mosquito
• replicate - replicate
• outcome - outcome
• time - time
• treatment - treatment
• mosquito - mosquito
• replicate - replicate
• outcome - outcome
• time - time
• treatment - treatment
• mosquito - mosquito
• replicate - replicate
• outcome - outcome
• time - time
• treatment - treatment
• mosquito - mosquito
• replicate - replicate
• outcome - outcome
• time - time
• treatment - treatment
• mosquito - mosquito
• replicate - replicate
• outcome - outcome
• time - time
• treatment - treatment
• mosquito - mosquito
• replicate - replicate
• outcome - outcome
• time - time
• treatment - treatment

f6970286 Location:

Summary Statistics: Min. 1.0; Max. 872.0; Mean 436.5; StDev 251.86901357650171; Valid 872.0

Variable Format: numeric

Notes: UNF:6:JURSrCUpkbl/71zKLTTkjw==

f6970286 Location:

Summary Statistics: Max. 3.0; Valid 872.0; StDev 0.8149678038445182; Mean 2.0240825688073403; Min. 1.0

Variable Format: numeric

Notes: UNF:6:JHnU3yCkaCJ8/FYb6D67Mw==

f6970286 Location:

Summary Statistics: StDev 0.473403641854395; Max. 1.0; Mean 0.6616972477064192; Min. 0.0; Valid 872.0

Variable Format: numeric

Notes: UNF:6:1LLcVeRYlXlBECHwnx7OUA==

f6970286 Location:

Summary Statistics: Max. 28.0; Valid 872.0; StDev 11.925465055358165; Mean 15.863532110091695; Min. 0.0

Variable Format: numeric

Notes: UNF:6:Y3uCwNPZ2sCt64fiJk2a6A==

f6970286 Location:

Variable Format: character

Notes: UNF:6:B4xYjsFqMtM75tu35aMXZA==

f6970287 Location:

Summary Statistics: Min. 1.0; Valid 830.0; Mean 415.5; StDev 239.7446558319914; Max. 830.0

Variable Format: numeric

Notes: UNF:6:SlcnSzpISXZ9ykrMYc6gVw==

f6970287 Location:

Summary Statistics: Min. 1.0; StDev 0.8203949051335887; Mean 2.00722891566265; Valid 830.0; Max. 3.0

Variable Format: numeric

Notes: UNF:6:L16QAXRYW7tQNIVkwdRUQw==

f6970287 Location:

Summary Statistics: StDev 0.47140383567925015; Min. 0.0; Mean 0.6674698795180739; Max. 1.0; Valid 830.0

Variable Format: numeric

Notes: UNF:6:AZD4az95hQ6Fo+th4Yq3PQ==

f6970287 Location:

Summary Statistics: StDev 11.999520630282609; Mean 15.127710843373535; Min. 0.0; Max. 28.0; Valid 830.0

Variable Format: numeric

Notes: UNF:6:qt2VHbVuSn/o5s3UR0k4IQ==

f6970287 Location:

Variable Format: character

Notes: UNF:6:wfn/Yli1Sfr+AD/AjVVdRA==

f6970282 Location:

Summary Statistics: Max. 922.0; Valid 922.0; StDev 266.3027725478401; Mean 461.5; Min. 1.0

Variable Format: numeric

Notes: UNF:6:RM/f8Ag+PikU+eQJCjQYpg==

f6970282 Location:

Summary Statistics: Valid 922.0; Mean 2.014099783080259; StDev 0.8157094277971342; Min. 1.0; Max. 3.0

Variable Format: numeric

Notes: UNF:6:FrrmAgipYWQ6sFv8U57SuA==

f6970282 Location:

Summary Statistics: StDev 0.4408011798852567; Mean 0.736442516268981; Max. 1.0; Min. 0.0; Valid 922.0

Variable Format: numeric

Notes: UNF:6:mUhWXBMVdWUuewNe0HqoDg==

f6970282 Location:

Summary Statistics: Min. 0.0; StDev 10.65980107301268; Valid 922.0; Max. 28.0; Mean 12.737527114967461

Variable Format: numeric

Notes: UNF:6:9pgS95Es+rhCUS669OGbDw==

f6970282 Location:

Variable Format: character

Notes: UNF:6:NkLaesNBDr2hyRVc5hOysQ==

f6970288 Location:

Summary Statistics: Min. 1.0; StDev 172.7720077636035; Max. 598.0; Mean 299.5; Valid 598.0

Variable Format: numeric

Notes: UNF:6:omG/UiLAzdtjNYxN7FsluQ==

f6970288 Location:

Summary Statistics: StDev 0.7618724488374425; Min. 1.0; Max. 3.0; Mean 2.2876254180602; Valid 598.0;

Variable Format: numeric

Notes: UNF:6:SNYZ2tUaFkhbG+Yb47PxHQ==

f6970288 Location:

Summary Statistics: Mean 0.4180602006688956; StDev 0.49365310016698993; Max. 1.0; Valid 598.0; Min. 0.0;

Variable Format: numeric

Notes: UNF:6:xkUz0YOznR36a/0CR2aPNw==

f6970288 Location:

Summary Statistics: Min. 1.0; Mean 10.220735785953181; Max. 14.0; StDev 4.997296233161194; Valid 598.0;

Variable Format: numeric

Notes: UNF:6:6ZgV28HZnRLQ4p2QwrZ+Og==

f6970288 Location:

Variable Format: character

Notes: UNF:6:Pc1GxevkQmvCmDpqr0cJ5A==

f6970285 Location:

Summary Statistics: Valid 894.0; Max. 894.0; Min. 1.0; Mean 447.5; StDev 258.2198675547643

Variable Format: numeric

Notes: UNF:6:FqmuCtB+NtF/W8he2xzVqA==

f6970285 Location:

Summary Statistics: Valid 894.0; Max. 3.0; Mean 1.9966442953020143; Min. 1.0; StDev 0.8162610609927874

Variable Format: numeric

Notes: UNF:6:77/nk/RaStKXbfnLPbLC2A==

f6970285 Location:

Summary Statistics: Valid 894.0; Min. 0.0; Mean 0.3780760626398215; Max. 1.0; StDev 0.48517817559030224

Variable Format: numeric

Notes: UNF:6:z2DBpZfUIFudxPSSYCraJg==

f6970285 Location:

Summary Statistics: Max. 28.0; StDev 9.12897939551871; Valid 894.0; Min. 0.0; Mean 22.23154362416107

Variable Format: numeric

Notes: UNF:6:br5G7Ijo7RixRjgHiLjSaw==

f6970285 Location:

Variable Format: character

Notes: UNF:6:Ji1HECBgd0T7JrcjE1uOMw==

f6970280 Location:

Summary Statistics: Max. 815.0; Min. 1.0; StDev 235.41452801388448; Mean 408.0; Valid 815.0;

Variable Format: numeric

Notes: UNF:6:9uJiZBfzWAuaV3WlIrkf0A==

f6970280 Location:

Summary Statistics: Min. 1.0; Max. 3.0; Valid 815.0; StDev 0.8114657469521794; Mean 2.0

Variable Format: numeric

Notes: UNF:6:Xg9ylppVijdvIL8bLVYpfA==

f6970280 Location:

Summary Statistics: StDev 0.47437143997617887; Max. 1.0; Valid 815.0; Mean 0.6588957055214714; Min. 0.0;

Variable Format: numeric

Notes: UNF:6:wUPpQsNArRQxcDwO/YUDPA==

f6970280 Location:

Summary Statistics: Min. 0.0; Valid 815.0; StDev 11.640375569866466; Mean 13.586503067484735; Max. 28.0;

Variable Format: numeric

Notes: UNF:6:Lyqs+9KWfnerHx8X6fEr+Q==

f6970280 Location:

Variable Format: character

Notes: UNF:6:HDUsjUppPbibTB2tHe58Hg==

f6970283 Location:

Summary Statistics: Min. 1.0; Mean 453.5; Max. 906.0; StDev 261.6839697039159; Valid 906.0;

Variable Format: numeric

Notes: UNF:6:fguvBn7E/wWvhwABlet0jA==

f6970283 Location:

Summary Statistics: Valid 906.0; StDev 0.8169356162245539; Mean 1.9955849889624735; Min. 1.0; Max. 3.0

Variable Format: numeric

Notes: UNF:6:2tZaFFwziFEZDjQUN0ydkA==

f6970283 Location:

Summary Statistics: StDev 0.47087816356606016; Min. 0.0; Mean 0.6688741721854309; Valid 906.0; Max. 1.0

Variable Format: numeric

Notes: UNF:6:ijXiZsEMbPzW+Rtnr71b5g==

f6970283 Location:

Summary Statistics: StDev 9.588123512836525; Valid 906.0; Min. 0.0; Max. 28.0; Mean 19.94812362030902;

Variable Format: numeric

Notes: UNF:6:kB9HIRnU2vbWoH+DItdB8g==

f6970283 Location:

Variable Format: character

Notes: UNF:6:6bLj2BeZSxHVhQ+ZHg13Ew==

Label:

KOminde_ivermectin_bioefficacy_data_codebook.pdf

application/pdf

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KOminde_ivermectin_bioefficacy_data_readme.txt

text/plain

Label:

Meal size estimation IVM Bioefficacy_Rep2.xlsx

application/vnd.openxmlformats-officedocument.spreadsheetml.sheet

Label:

Meal size estimation IVM Bioefficacy.xlsx

application/vnd.openxmlformats-officedocument.spreadsheetml.sheet

Label:

Species ID by Morphology and PCR.xlsx

application/vnd.openxmlformats-officedocument.spreadsheetml.sheet