Replication Data for: Systemic Inflammation is Negatively Associated with Early Post Discharge Growth following Acute Illness among Severely Malnourished Children- a Pilot Study

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Njunge, James M.; Gonzales, Gerard B.; Ngari, Moses M.; Thitiri, Johnstone; Bandsma, Robert H.J.; Berkley, James A., 2020, "Replication Data for: Systemic Inflammation is Negatively Associated with Early Post Discharge Growth following Acute Illness among Severely Malnourished Children- a Pilot Study", https://doi.org/10.7910/DVN/5DKLVI, Harvard Dataverse, V1, UNF:6:QLujfK2zSCp6JTUtQTXP/Q== [fileUNF]

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Description	This is a replication dataset for the published paper "Systemic Inflammation is Negatively Associated with Early Post Discharge Growth following Acute Illness among Severely Malnourished Children- a Pilot Study" published in the Wellcome Open Research journal. This was a secondary analysis of data from a nested case control study within a clinical trial (NCT00934492) that tested the efficacy of daily co‐trimoxazole prophylaxis in reducing post‐discharge mortality among HIV‐uninfected children aged 2-59 months hospitalised with Complicated Severe Malnutrition (CSM) in two urban (Mombasa and Nairobi) and two rural (Kilifi and Malindi) hospitals in Kenya. We examined the relationship between changes in absolute deficits in weight and mid-upper-arm circumference (MUAC) from enrolment at stabilisation to 60 days later and untargeted plasma proteome, targeted cytokines/chemokines, leptin, and soluble CD14 (sCD14) using multivariate regularized linear regression. Dataset files included : (i) Njunge_CTX_15092020.dta and (ii) Njunge_CTX_15092020.csv Both files contain similar infomation. The files contains athropometric at the time of hospital discharge and during follow up months 1, 2, 3, 4, 5, 6, 8, 10, and 12. A full blood count at enrolment, 2, 6, and 12 months. Anthropometric z scores calculated using 2006 WHO growth references. Study data were entered into OpenClinical trial database. After locking the trial database, the data were extrcated and exported to STATA Version 13.1 for statistical analysis. Participants included in this study were non-oedematous children with Severe Malnutrition randomly selected from those who survived and were not readmitted to hospital during 12 months of follow up and had completed follow-up data at month 12. They had served as controls in a previous case control study (Njunge, J.M., et al., 2019. Biomarkers of post-discharge mortality among children with complicated severe acute malnutrition. Scientific reports, 9(1):5981. https://doi.org/1038/s41598-019-42436-y.) in which plasma proteomic and cytokine measurements had been done on enrolment samples. Absolute deficit in anthropometric variables were defined as the median value for age according to WHO growth charts minus the child’s measured value. The files also contain plasma proteome, leptin, sCD14 and a panel of targeted cytokines. The two files were generated using STATA/IC (version 15.1; StataCorp, College Station, TX, USA).
Subject	Medicine, Health and Life Sciences
Related Publication	Njunge JM, Gonzales GB, Ngari MM et al. Systemic inflammation is negatively associated with early post discharge growth following acute illness among severely malnourished children - a pilot study [version 1; peer review: awaiting peer review]. Wellcome Open Res 2020, 5:248 (https://doi.org/10.12688/wellcomeopenres.16330.1)doi: 10.12688/wellcomeopenres.16330.1
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	1 to 7 of 7 Files	Original Format Archival Format (.tab)
	NjungeJM_Inflammation_Readme.txt Plain Text - 9.1 KB Published Sep 17, 2020 19 Downloads MD5: 0ef429505e703b59e5f9cd2beafbdc03 DocumentationReadme	Preview "NjungeJM_Inflammation_Readme.txt" Access File File Access Public Download Options Plain Text Download Metadata Data File Citation Download EndNote XML Download RIS Download BibTeX
	Njunge_Inflammation_Codebook.pdf Adobe PDF - 386.2 KB Published Sep 17, 2020 25 Downloads MD5: cbd48ebd7375a530f713b3d9643e3613 contains a list of all the variables in the two datasets and their description. DocumentationData Dictionary	Preview "Njunge_Inflammation_Codebook.pdf" Access File File Access Public Download Options Adobe PDF Download Metadata Data File Citation Download EndNote XML Download RIS Download BibTeX
	Njunge_CTX_15092020-1.tab Tabular Data - 361.1 KB Published Sep 17, 2020 23 Downloads 483 Variables, 98 Observations UNF:6:FjieMiB/r6SPe9oJ/D6ywQ== DataSTATA	Preview "Njunge_CTX_15092020-1.tab" Preview "Njunge_CTX_15092020-1.tab" Access File File Access Public Download Options Stata 14 Binary (Original File Format) Tab-Delimited RData Download Metadata DDI Codebook v2 Data File Citation Download EndNote XML Download RIS Download BibTeX Explore Options Data Explorer v2
	Njunge_CTX_15092020.tab Tabular Data - 378.4 KB Published Sep 17, 2020 30 Downloads 483 Variables, 98 Observations UNF:6:oIuow35vKbjTsgIAWEbIuA== DataCSV	Preview "Njunge_CTX_15092020.tab" Preview "Njunge_CTX_15092020.tab" Access File File Access Public Download Options Comma Separated Values (Original File Format) Tab-Delimited RData Download Metadata DDI Codebook v2 Data File Citation Download EndNote XML Download RIS Download BibTeX Explore Options Data Explorer v2
	Njunge_EN_Glmnet_bootValidation.r R Syntax - 9.7 KB Published Sep 17, 2020 24 Downloads MD5: 163667b303f8a6242f40c2df5c8a6ee3 CodeR script	Preview "Njunge_EN_Glmnet_bootValidation.r" Access File File Access Public Download Options R Syntax Download Metadata Data File Citation Download EndNote XML Download RIS Download BibTeX
	Njunge_Stata_Do.do Stata Syntax - 8.4 KB Published Sep 17, 2020 16 Downloads MD5: 3c9939c61b565494de284a55e0bb82a5 This analysis script uses Njunge_CTX_15092020.dta to generate the summary participants characteristics at enrolment and at 2 months and calculate the changes in anthropometry CodeSTATA	Preview "Njunge_Stata_Do.do" Access File File Access Public Download Options Stata Syntax Download Metadata Data File Citation Download EndNote XML Download RIS Download BibTeX
	Njunge_STROBE_checklist_cohort.pdf Adobe PDF - 393.3 KB Published Sep 17, 2020 21 Downloads MD5: a3ceda087b99ead5b288bcb5ed5db8b4 duly completed STROBE checklist for Cohort studies Extended Data	Preview "Njunge_STROBE_checklist_cohort.pdf" Access File File Access Public Download Options Adobe PDF Download Metadata Data File Citation Download EndNote XML Download RIS Download BibTeX

Citation Metadata

Persistent Identifier	doi:10.7910/DVN/5DKLVI
Publication Date	2020-09-17
Title	Replication Data for: Systemic Inflammation is Negatively Associated with Early Post Discharge Growth following Acute Illness among Severely Malnourished Children- a Pilot Study
Author	KEMRI-Wellcome Trust Research Programme, P.O Box 230, Kilifi, 80108, Kenyahttps://orcid.org/0000-0002-8524-9133 Department of Internal Medicine and Pediatrics, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgiumhttps://orcid.org/0000-0001-6614-3520 KEMRI-Wellcome Trust Research Programme, P.O Box 230, Kilifi, 80108, Kenyahttp://orcid.org/0000-0001-7149-5491 KEMRI-Wellcome Trust Research Programme, P.O Box 230, Kilifi, 80108, Kenyahttps://orcid.org/0000-0002-5901-6651 Centre for Global Child Health, The Hospital for Sick Children, Toronto, Ontario, Canadahttps://orcid.org/0000-0001-6358-4750 KEMRI-Wellcome Trust Research Programme, P.O Box 230, Kilifi, 80108, Kenyahttp://orcid.org/0000-0002-1236-849X
Point of Contact	Use email button above to contact. Njunge, James M. (KEMRI-Wellcome Trust Research Programme, P.O Box 230, Kilifi, 80108, Kenya)
Description	This is a replication dataset for the published paper "Systemic Inflammation is Negatively Associated with Early Post Discharge Growth following Acute Illness among Severely Malnourished Children- a Pilot Study" published in the Wellcome Open Research journal. This was a secondary analysis of data from a nested case control study within a clinical trial (NCT00934492) that tested the efficacy of daily co‐trimoxazole prophylaxis in reducing post‐discharge mortality among HIV‐uninfected children aged 2-59 months hospitalised with Complicated Severe Malnutrition (CSM) in two urban (Mombasa and Nairobi) and two rural (Kilifi and Malindi) hospitals in Kenya. We examined the relationship between changes in absolute deficits in weight and mid-upper-arm circumference (MUAC) from enrolment at stabilisation to 60 days later and untargeted plasma proteome, targeted cytokines/chemokines, leptin, and soluble CD14 (sCD14) using multivariate regularized linear regression. Dataset files included : (i) Njunge_CTX_15092020.dta and (ii) Njunge_CTX_15092020.csv Both files contain similar infomation. The files contains athropometric at the time of hospital discharge and during follow up months 1, 2, 3, 4, 5, 6, 8, 10, and 12. A full blood count at enrolment, 2, 6, and 12 months. Anthropometric z scores calculated using 2006 WHO growth references. Study data were entered into OpenClinical trial database. After locking the trial database, the data were extrcated and exported to STATA Version 13.1 for statistical analysis. Participants included in this study were non-oedematous children with Severe Malnutrition randomly selected from those who survived and were not readmitted to hospital during 12 months of follow up and had completed follow-up data at month 12. They had served as controls in a previous case control study (Njunge, J.M., et al., 2019. Biomarkers of post-discharge mortality among children with complicated severe acute malnutrition. Scientific reports, 9(1):5981. https://doi.org/1038/s41598-019-42436-y.) in which plasma proteomic and cytokine measurements had been done on enrolment samples. Absolute deficit in anthropometric variables were defined as the median value for age according to WHO growth charts minus the child’s measured value. The files also contain plasma proteome, leptin, sCD14 and a panel of targeted cytokines. The two files were generated using STATA/IC (version 15.1; StataCorp, College Station, TX, USA).
Subject	Medicine, Health and Life Sciences
Related Publication	Njunge JM, Gonzales GB, Ngari MM et al. Systemic inflammation is negatively associated with early post discharge growth following acute illness among severely malnourished children - a pilot study [version 1; peer review: awaiting peer review]. Wellcome Open Res 2020, 5:248 (https://doi.org/10.12688/wellcomeopenres.16330.1) doi 10.12688/wellcomeopenres.16330.1 https://doi.org/10.12688/wellcomeopenres.16330.1 Njunge, J.M., Gwela, A., Kibinge, N.K., Ngari, M., Nyamako, L., Nyatichi. E., Thitiri, J., Gonzales, G.B., Bandsma, R.H.J., Walson, J.L., Gitau, E.N., Berkley, J.A., 2019. Biomarkers of post-discharge mortality among children with complicated severe acute malnutrition. Scientific reports, 9(1):5981. doi 1038/s41598-019-42436-y https://doi.org/1038/s41598-019-42436-y Berkley, J.A., Ngari, M., Thitiri, J., Mwalekwa, L., Timbwa, M., Hamid, F., Ali, R., Shangala, J., Mturi, N., Jones, K.D. and Alphan, H., 2016. Daily co-trimoxazole prophylaxis to prevent mortality in children with complicated severe acute malnutrition: a multicentre, double-blind, randomised placebo-controlled trial. The Lancet Global Health, 4(7), pp.e464-e473. doi: 10.1016/S2214-109X(16)30096-1. 10.1016/S2214-109X(16)30096-1. https://doi.org/10.1016/S2214-109X(16)30096-1.
Depositor	Njunge, James M.
Deposit Date	2020-09-17

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