Replication Data for: Evaluation of population immunity against SARS-CoV-2 variants, EG.5.1, FY.4, BA.2.86, JN.1, and JN.1.4, using samples from two health demographic surveillance systems in Kenya

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Lugano, Doreen; Kutima, Bernadette; Kimani, Makobu; Sigilai, Antipa; Gitonga, John N.; Karani, Angela; Akech, Donald; Karia,Boniface; Wairimu, Angela; Lambisia, Arnold; Omuoyo, Donwilliams; Lucinde, Ruth; Ziraba, Abdhalah K.; Newman, Joseph; Bailey, Dalan; Githinji, George; Agoti, Charles N.; Sande, Charles; Kagucia, Wangeci; Ochola-Oyier, Lynette I.; Bejon, Philip; Scott, J. Anthony G.; Agweyu, Ambrose; Warimwe, George M.; Nyagwange, James, 2024, "Replication Data for: Evaluation of population immunity against SARS-CoV-2 variants, EG.5.1, FY.4, BA.2.86, JN.1, and JN.1.4, using samples from two health demographic surveillance systems in Kenya", https://doi.org/10.7910/DVN/6DSHMB, Harvard Dataverse, V1
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Description

This is a replication dataset for the manuscript titled:Evaluation of population immunity against SARS-CoV-2 variants, EG.5.1, FY.4, BA.2.86, JN.1, and JN.1.4, using samples from two health demographic surveillance systems in Kenya.

SARS-CoV-2 virus continues to mutate leading to emerging variants that escape immunity previously raised by vaccination and/or infection by earlier variants. We used genomic data to identify the most prevalent Kenyan and global variants between May 2023 and March 2024 and performed pseudoviruses neutralization assays on samples collected from two health demographic surveillance systems in Kenya (n=54), for vaccine induced immunity against circulating variants EG.5.1, FY.4 19, BA.2.86, JN.1, and JN.1.4. As a comparator, we used natural wildtype infection samples (n=20) collected in 2020 at the onset of the pandemic and confirmed to be PCR positive for SARS-CoV-2. We also assessed the effects of different doses of vaccine, age, sex, and type of vaccine on antibody-neutralizing titers.

Subject Medicine, Health and Life Sciences
Keyword SARS-CoV-2 variants, vaccination, neutralization, population immunity
Related Publication Nyagwange, J. et al. Serum immunoglobulin G and mucosal immunoglobulin A antibodies from prepandemic samples collected in Kilifi, Kenya, neutralize SARS-CoV-2 in vitro. International Journal of Infectious Diseases 127, (2023). Lambisia, A. W. et al. Detection of a SARS-CoV-2 Beta-like variant in coastal Kenya after more than a year of disappearance. Wellcome Open Res 8, (2023).
Notes Data Access : Data will be open access under the terms of the Creative Commons CC By 4.0 License.
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