Persistent Identifier
|
doi:10.7910/DVN/CEQ1OL |
Publication Date
|
2021-10-22 |
Title
| Replication Data for: Biomarkers of post-discharge mortality among children with complicated severe acute malnutrition |
Author
| Njunge, James M.KEMRI-Wellcome Trust Research Programme, Kilifi, KenyaORCIDhttps://orcid.org/0000-0002-8524-9133
Gwela, AgnesKEMRI-Wellcome Trust Research Programme, Kilifi, Kenya
Kibinge, Nelson K.KEMRI-Wellcome Trust Research Programme, Kilifi, KenyaORCIDhttps://orcid.org/0000-0002-1980-2017
Ngari, Moses M.KEMRI-Wellcome Trust Research Programme, Kilifi, KenyaORCIDhttp://orcid.org/0000-0001-7149-5491
Nyamako, LydiaKEMRI-Wellcome Trust Research Programme, Kilifi, Kenya
Nyatichi, EmilyKEMRI-Wellcome Trust Research Programme, Kilifi, Kenya
Thitiri, JohnstoneKEMRI-Wellcome Trust Research Programme, Kilifi, KenyaORCIDhttps://orcid.org/0000-0002-5901-6651
Gonzales, Gerard B.Department of Internal Medicine and Pediatrics, Faculty of Medicine and Health Sciences, Ghent University, Ghent, BelgiumORCIDhttps://orcid.org/0000-0001-6614-3520
Bandsma, Robert H.J.Centre for Global Child Health, The Hospital for Sick Children, Toronto, Ontario, CanadaORCIDhttps://orcid.org/0000-0001-6358-4750
Walson, JuddDepartments of Global Health, Medicine, Paediatrics and Epidemiology, University of Washington, Seattle, Washington, USA.ORCIDhttps://orcid.org/0000-0003-4836-720X
Gitau, EvelynAfrican Population and Health Research Centre, Nairobi, KenyaORCIDhttps://orcid.org/0000-0002-5270-7492
Berkley, James A.KEMRI-Wellcome Trust Research Programme, Kilifi, KenyaORCIDhttp://orcid.org/0000-0002-1236-849X |
Point of Contact
|
Use email button above to contact.
Njunge, James M. (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya)
The Data Governance Committee (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya) |
Description
| This was a nested case control study within a clinical trial (NCT00934492) that tested the efficacy of daily co‐trimoxazole prophylaxis in reducing post‐discharge mortality among HIV‐uninfected children aged 2-59 months hospitalised with CSM in two urban (Mombasa and Nairobi) and two rural (Kilifi and Malindi) hospitals in Kenya. We investigated mechanisms underlying early post-discharge mortality (<60 days) using untargeted plasma proteome, targeted cytokines/chemokines, leptin, and soluble CD14 (sCD14) measured after hospital stabilisation (at discharge).
Data package includes:
- Njunge_Sci_Rep_s41598-019-42436-y.dta and (b) Njunge_Sci_Rep_s41598-019-42436-y.csv: Both files contain similar information. The files contains anthropometric at the time of hospital discharge for study children. It also contains full blood count at enrolment. Anthropometric z scores calculated using 2006 WHO growth references. Study data were entered into OpenClinical trial database. After locking the trial database, the data were extracated and exported to STATA Version 15.1 for statistical analysis.
- Njunge_Sci_Rep_s41598-019-42436-y.do This analysis script is used to generate the summary participants characteristics at enrolment and conduct regression analysis.
- Data Dictionary: contains variable descriptions and value labels
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Subject
| Medicine, Health and Life Sciences |
Keyword
| severe malnutrition
child growth
weight
mid-upper arm circumference
anthropometric deficit
inflammation
cytokines
proteome |
Related Publication
| Njunge, J.M., Gwela, A., Kibinge, N.K., Ngari, M., Nyamako, L., Nyatichi, E., Thitiri, J., Gonzales, G.B., Bandsma, R.H., Walson, J.L. and Gitau, E.N., 2019. Biomarkers of post-discharge mortality among children with complicated severe acute malnutrition. Scientific reports, 9(1), pp.1-12. doi 10.1038/s41598-019-42436-y https://doi.org/10.1038/s41598-019-42436-y
Berkley, J.A., Ngari, M., Thitiri, J., Mwalekwa, L., Timbwa, M., Hamid, F., Ali, R., Shangala, J., Mturi, N., Jones, K.D. and Alphan, H., 2016. Daily co-trimoxazole prophylaxis to prevent mortality in children with complicated severe acute malnutrition: a multicentre, double-blind, randomised placebo-controlled trial. The Lancet Global Health, 4(7), pp.e464-e473. doi 10.1016/S2214-109X(16)30096-1 https://doi.org//10.1016/S2214-109X(16)30096-1 |
Notes
| Data Access: Open
License: Creative Commons Attribution 4.0 International |
Funding Information
| Wellcome Trust: WT083579MA
Bill & Melinda Gates Foundation: OPP1131320 |
Depositor
| Njunge, James M. |
Deposit Date
| 2021-10-21 |
Data Type
| Clinical Trial |
Related Dataset
| The mass spectrometry raw files generated and analysed in the current study have been deposited to the ProteomeXchange Consortium73 (PXD010668), via the MassIVE partner repository (MSV000082745), under the following title: Biomarkers of post-stabilization mortality in severe acute malnutrition. |