Replication Data for: Lifelong malaria exposure drives B cell activation and post-transcriptional regulation while suppressing inflammatory transcriptional programs

Version 2.0
Kimotho, John; Mwikali, Kioko; Mudibo, Evans; Muthui, Michelle; Murungi, Linda; Muia, Alfred; Namwoso, Lynn; Kimani, Makobu; Orimbo, John; Ogutu, Benhards; Muema, Daniel; Ndung'u, Thumbi; Rono, Martin; Nduati, Eunice W., 2025, "Replication Data for: Lifelong malaria exposure drives B cell activation and post-transcriptional regulation while suppressing inflammatory transcriptional programs", https://doi.org/10.7910/DVN/CN5CEU, Harvard Dataverse, V2, UNF:6:AmHvRBwDgpMwE2GvldNKrg== [fileUNF]
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Description

This is a replication dataset for the manuscript titled: "Lifelong malaria exposure drives B cell activation and post-transcriptional regulation while suppressing inflammatory transcriptional programs ."

This dataset was generated as part of a study investigating immunological signatures associated with lifelong malaria exposure among healthy adult participants from Kenya. It includes data collected across multiple malaria transmission settings and comprises:

  • Baseline participant characteristics (e.g., age, sex, site)
  • Raw and processed cytokine measurements from plasma samples
  • Raw and normalised RNA-seq counts from peripheral blood mononuclear cells (PBMCs), including both unprocessed gene-level counts and counts normalised to counts per million (CPM)
  • An R Markdown file with annotated statistical code used for data processing and analysis
Subject Medicine, Health and Life Sciences
Keyword Chronic exposure, pathogen exposure, Immune activation, Immune tolerance, Immunomodulation, Immune imprinting, Malaria
License/Data Use Agreement

CC BY 4.0

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Jkimotho_DATASET_Codebook.xlsx
MS Excel Spreadsheet - 256.9 KB
Published Jun 23, 2025
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MD5: b7006882b8f94be0be22283e5be8cc6b
DocumentationVariable Codebook/Data Dictionary
JKimotho_DATASET_Readme_V2.txt
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Published Jun 26, 2025
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MD5: bbf10d683563530e8fc4417de56035c3
DocumentationReadme
Preview "JKimotho_DATASET_Readme_V2.txt"
Jkimotho_Baseline_Characteristics.tab
Tabular Data - 8.4 KB
Published Jun 23, 2025
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23 Variables, 60 Observations UNF:6:EwwwV1CiWzKU7tpW2Njy4w==
Participant's baseline characteristics
Datacsv file
JKimotho_Cytokine_ProcessedData.tab
Tabular Data - 13.9 KB
Published Jun 23, 2025
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39 Variables, 60 Observations UNF:6:9PPgLALHDqCvGQ4wqYxz9w==
Cytokine processed data
Datacsv file
JKimotho_Cytokine_RawData.tab
Tabular Data - 19.5 KB
Published Jun 23, 2025
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69 Variables, 76 Observations UNF:6:L29rYTMGE39Xen3AhjC/Ag==
Cytokine raw data
Datacsv file
JKimotho_ProcessedCPM_SeqData.tab
Tabular Data - 10.3 MB
Published Jun 23, 2025
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62 Variables, 14576 Observations UNF:6:x66s5OUuWzU9Tkcui9OIjw==
Sequence data processed data/counts per million
Data
JKimotho_RawCounts_SeqData.tab
Tabular Data - 9.0 MB
Published Jun 23, 2025
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61 Variables, 38378 Observations UNF:6:l/JcUffs5TElOG+XRU3q5Q==
Sequence data raw RNA counts
Datacsv file
SupplementaryFile_R_codes.Rmd
R Notebook - 144.0 KB
Published Jun 23, 2025
1 Download
MD5: f0e8a32b46acf442aac146a87f98da3b
CodeR script
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