Replication Data for: Systemic biological mechanisms underpin poor post-discharge growth among severely wasted children with HIV

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Mudibo, Evans O.; Bogaert, Jasper; Tigoi, Caroline; Ngari, Moses M.; Singa, Benson O.; Lancioni, Christina L.; Diallo, Abdoulaye Hama; Mbale, Emmie; Thitiri, Johnstone; Timbwa, Molline; Omer, Elisha; Ngao, Narshion; Musyimi,Robert; Kahindi, Eunice; Mupere, Ezekiel; Mukisa,John; Bamouni, Roseline Maïmouna; Bandsma, Robert H.J.; Kelly, Paul; Prendergast, Andrew J.; McGrath, Christine J.; Tickell, Kirkby D.; Walson, Judd L.; Berkley, James A.; Njunge, James M.; Gonzales, Gerard Bryan., 2024, "Replication Data for: Systemic biological mechanisms underpin poor post-discharge growth among severely wasted children with HIV", https://doi.org/10.7910/DVN/D8HZLJ, Harvard Dataverse, V2

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Description	This is a replication dataset for the manuscript titled: "*Systemic biological mechanisms underpin poor post-discharge growth among severely wasted children with HIV*." In sub-Saharan Africa, a proportion of children hospitalised with severe malnutrition (SM) also have HIV infection (HIV-SM). Children with HIV-SM have poorer clinical outcomes than children with SM alone. They face high mortality both during and after hospitalisation, have impaired nutritional recovery post-hospitalisation and have increased relapse recovery. Despite this elevated risks biological mechanisms underlying the risk remain unclear. This study is nested with the CHAIN cohort sites in Kenya, Uganda, Malawi and Burkina Faso. The current study aimed to understand how HIV influences post-discharge growth among children with HIV-SM in sub-Saharan Africa. In the current study proteins from plasma collected from children at hospital discharge were quantified using SomaScan assay. Over 7300 proteins were quantified. The analysis also included anthropometric measurements e.g., mid-upper arm circumference, weight-for-age, weight-for-height and height-for-age scores taken at discharge, 45-days post-discharge, 90-days post-discharge, and 180-days post-discharge. Demographic data included sex, age, site of enrolment.
Subject	Medicine, Health and Life Sciences
Keyword	HIV, Severe malnutrition, Protein modules, Biological processes, Structural equation modelling, Post-discharge growth
Related Publication	Njunge JM, Tickell K, Diallo AH et al. The Childhood Acute Illness and Nutrition (CHAIN) network nested case-cohort study protocol: a multi-omics approach to understanding mortality among children in sub-Saharan Africa and South Asia [version 2; peer review: 2 approved]. Gates Open Res 2022, 6:77doi: https://doi.org/10.12688/gatesopenres.13635.2
Notes	Data Access Access to these data requires submission of a formal request for consideration by our Data Governance Committee. How to request Download and complete the data request form Email completed data request form to the Data Governance Committee at dgc@kemri-wellcome.org
License/Data Use Agreement	CC BY 4.0

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Citation Metadata

Persistent Identifier	doi:10.7910/DVN/D8HZLJ
Publication Date	2024-06-05
Title	Replication Data for: Systemic biological mechanisms underpin poor post-discharge growth among severely wasted children with HIV
Author	Mudibo, Evans O.KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya Bogaert, Jasperepartment of Data Analysis, Faculty of Psychology and Education Sciences, Ghent University Tigoi, CarolineKEMRI-Wellcome Trust Research Programme, Kilifi, Kenya Ngari, Moses M.KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya Singa, Benson O.Center for Clinical Research, Kenya Medical Research Institute, Nairobi, Kenya Lancioni, Christina L.Department of Pediatrics, Oregon Health and Science University, Portland, OR, USA Diallo, Abdoulaye HamaDepartment of Public Health, University Joseph Ki-Zerbo, Ouagadougou, Burkina Faso Mbale, EmmieDepartment of Paediatrics and Child Health, Kamuzu University of Health Sciences, Blantyre, Malawi Thitiri, JohnstoneKEMRI-Wellcome Trust Research Programme, Kilifi, Kenya Timbwa, MollineKEMRI-Wellcome Trust Research Programme, Kilifi, Kenya Omer, ElishaKEMRI-Wellcome Trust Research Programme, Kilifi, Kenya Ngao, NarshionKEMRI-Wellcome Trust Research Programme, Kilifi, Kenya Musyimi,RobertKEMRI-Wellcome Trust Research Programme, Kilifi, Kenya Kahindi, EuniceKEMRI-Wellcome Trust Research Programme, Kilifi, Kenya Mupere, EzekielDepartment of Paediatrics and Child Health, Makerere University College of Health Sciences, Kampala, Uganda Mukisa,JohnDepartment of Immunology and Department of Molecular Biology Makerere University College of Health Sciences, Kampala, Uganda Bamouni, Roseline MaïmounaDepartment of Pediatrics and Child Health, Aga Khan University, Karachi, Pakistan Bandsma, Robert H.J.Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, ON, Canada Kelly, PaulTropical Gastroenterology and Nutrition Group, Department of Medicine, University of Zambia School of Medicine, Lusaka, Zambia Prendergast, Andrew J.Zvitambo Institute for Maternal and Child Health Research, 16 Lauchlan Ave, Meyrick Park, Harare, Zimbabwe McGrath, Christine J.Department of Global Health, University of Washington, Seattle, USA Tickell, Kirkby D.Department of Global Health, University of Washington, Seattle, USA Walson, Judd L.Departments of International Health, Pediatrics and Medicine, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA Berkley, James A.KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya Njunge, James M.KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya Gonzales, Gerard Bryan.Department of Public Health and Primary Care, Faculty of Medicine and Health Sciences, Ghent University
Point of Contact	Use email button above to contact. Mudibo, Evans O. (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya) Njunge, James M. (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya) The Data Governance Committee (KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya)
Description	This is a replication dataset for the manuscript titled: "*Systemic biological mechanisms underpin poor post-discharge growth among severely wasted children with HIV*." In sub-Saharan Africa, a proportion of children hospitalised with severe malnutrition (SM) also have HIV infection (HIV-SM). Children with HIV-SM have poorer clinical outcomes than children with SM alone. They face high mortality both during and after hospitalisation, have impaired nutritional recovery post-hospitalisation and have increased relapse recovery. Despite this elevated risks biological mechanisms underlying the risk remain unclear. This study is nested with the CHAIN cohort sites in Kenya, Uganda, Malawi and Burkina Faso. The current study aimed to understand how HIV influences post-discharge growth among children with HIV-SM in sub-Saharan Africa. In the current study proteins from plasma collected from children at hospital discharge were quantified using SomaScan assay. Over 7300 proteins were quantified. The analysis also included anthropometric measurements e.g., mid-upper arm circumference, weight-for-age, weight-for-height and height-for-age scores taken at discharge, 45-days post-discharge, 90-days post-discharge, and 180-days post-discharge. Demographic data included sex, age, site of enrolment.
Subject	Medicine, Health and Life Sciences
Keyword	HIV Severe malnutrition Protein modules Biological processes Structural equation modelling Post-discharge growth
Related Publication	Njunge JM, Tickell K, Diallo AH et al. The Childhood Acute Illness and Nutrition (CHAIN) network nested case-cohort study protocol: a multi-omics approach to understanding mortality among children in sub-Saharan Africa and South Asia [version 2; peer review: 2 approved]. Gates Open Res 2022, 6:77 doi https://doi.org/10.12688/gatesopenres.13635.2 https://gatesopenresearch.org/articles/6-77/v2
Notes	Data Access Access to these data requires submission of a formal request for consideration by our Data Governance Committee. How to request Download and complete the data request form Email completed data request form to the Data Governance Committee at dgc@kemri-wellcome.org
Depositor	Mudibo, Evans O.
Deposit Date	2024-06-05
Data Type	Restricted Access

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