New antigens for multi-component blood-stage vaccines against Plasmodium falciparum malaria

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New antigens for multi-component blood-stage vaccines against Plasmodium falciparum malaria
Osier, Faith; Kamuyu, Gathoni; Crosnier, Cécile; Wanaguru, Madushi; Oganda, Edna; McDade, Brian, 2017, "New antigens for multi-component blood-stage vaccines against Plasmodium falciparum malaria", https://doi.org/10.7910/DVN/EULHTX, Harvard Dataverse, V1, UNF:6:cFbr0Rlt8Ja7gGJDfq93mg== [fileUNF]
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Description

This dataset is from a prospective longitudinal cohort study of children from Chonyi village in Kilifi County, Kenya. The study was conducted for the purpose of evaluating the potential protective efficacy of antibodies to Plasmodium falciparum antigens against clinical episodes of malaria. Venous blood was collected from 286 children (age 1-10 years old) during a cross-sectional survey at the start of a malaria transmission season. Thick and thin blood smears were prepared for parasite detection by microscopy. Plasma was used to measure antibody levels to 39 Plasmodium falciparum merozoite surface and secreted proteins by enzyme linked immunosorbent assay. The children were then followed up for a period of 6 months with both active (Weekly home visits) and passive surveillance for malaria case detection.

Subject Medicine, Health and Life Sciences
Keyword Malaria, Merozoite, Plasmodium falciparum, Immunity, Vaccine
Related Publication Osier, F. H., M. J. Mackinnon, C. Crosnier, G. Fegan, G. Kamuyu, M. Wanaguru, E. Ogada, B. McDade, J. C. Rayner, G. J. Wright and K. Marsh (2014). "New antigens for a multicomponent blood-stage malaria vaccine." Sci Transl Med 6(247): 247ra102.10. DOI: 1126/scitranslmed.3008705 URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4856877/doi: 1126/scitranslmed.3008705
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44 Variables, 286 Observations UNF:6:cFbr0Rlt8Ja7gGJDfq93mg==
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