Replication Data for: Intestinal Disturbances Associated with Mortality of Children with Complicated Severe Malnutrition

Version 1.1
Replication Data for: Intestinal Disturbances Associated with Mortality of Children with Complicated Severe Malnutrition
Wen, Bijun; Farooqui,Amber; Bourdon, Celine; Ngari,Moses M.; Chimwezi, Emmanuel; Thitiri, Johnstone; Mwalekwa,Laura; Walson,Judd L.; Voskuijl,Wieger; Berkley, James A.; Bandsma,Robert H.J., 2023, "Replication Data for: Intestinal Disturbances Associated with Mortality of Children with Complicated Severe Malnutrition", https://doi.org/10.7910/DVN/I4EYDR, Harvard Dataverse, V1, UNF:6:91IeQamdBuBKIzOXzgZqIQ== [fileUNF]
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Description

This is a replication dataset for the manuscript titled: "Replication Data for: Intestinal Disturbances Associated with Mortality of Children with Complicated Severe Malnutrition."

This is data is from a case-control study nested within the F75 intervention trial. By comparing the fecal metabolomic profiles and enteropathy markers between cases (children who died, n=68) and controls (children who were discharged alive, n=68), this study aimed to understand the association between intestinal disturbances wnad mortality among children with severe malnutrition admitted to hospitals in Kenya and Malawi. Targeted fecal metabolomics were performed using nuclear magnetic resonance spectroscopy. A total 68 metabolites were targeted. Four enteropathy markers, myeloperoxidase, calprotectin, alpha-1-antitrypsin, and intestinal fatty acid binding protein were quantified by ELISA. Lyophilization was used to determine water content of fecal samples.

Subject Medicine, Health and Life Sciences
Keyword Severe malnutrition, mortality, enteropathy, metabolomics
Related Publication R. H. J. Bandsma et al., A reduced-carbohydrate and lactose-free formulation for stabilization among hospitalized children with severe acute malnutrition: A double-blind, randomized controlled trial. PLoS medicine 16, e1002747 (2019)doi: 10.1371/journal.pmed.1002747
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F75_Intestinal_codebook.pdf
F75_Intestinal_codebook.pdf
Adobe PDF - 213.4 KB
Published Jul 21, 2023
6 Downloads
MD5: 79172d8e46710ad62c1f0ceaa02828c2
This data dictionary contains a list of variables in the data file.
DocumentationVariable Codebook/Data Dictionary
Preview "F75_Intestinal_codebook.pdf"
F75_admission_fecal_combined.tab
Tabular Data - 358.3 KB
Published Jul 21, 2023
6 Downloads
150 Variables, 136 Observations UNF:6:1F3kalsWLD0sluj7fTrufg==
This file contains processed data used for analysis
Datacsv
Preview "F75_admission_fecal_combined.tab" Preview "F75_admission_fecal_combined.tab"
F75_admission_fecal_marker.tab
Tabular Data - 7.0 KB
Published Jul 21, 2023
9 Downloads
4 Variables, 133 Observations UNF:6:vDRML+iquNayeXCF9QaZpA==
This file contains raw wet weight concentrations of fecal enteropaty markers (myeloperoxidase, calprotectin, alpha-1-antitrypsin) quantified from fecal samples collected at admission
Datacsv
Preview "F75_admission_fecal_marker.tab" Preview "F75_admission_fecal_marker.tab"
F75_admission_fecal_metabolomics.tab
Tabular Data - 53.9 KB
Published Jul 21, 2023
26 Downloads
69 Variables, 137 Observations UNF:6:315FdHubZJUbthyz8y01Iw==
This file contains raw dry weight concentrations of metabolites quantified by H-NMR from fecal samples collected at admission
Datacsv
Preview "F75_admission_fecal_metabolomics.tab" Preview "F75_admission_fecal_metabolomics.tab"
F75_admission_serum_marker.tab
Tabular Data - 3.0 KB
Published Jul 21, 2023
5 Downloads
2 Variables, 118 Observations UNF:6:WyE1/mWB4+7r7cXaurCx4A==
This file contains raw concentrations of intestinal fatty acid binding protein quantified from serum samples collected at admission
Datacsv
Preview "F75_admission_serum_marker.tab" Preview "F75_admission_serum_marker.tab"
F75_metgroup.tab
Tabular Data - 3.9 KB
Published Jul 21, 2023
5 Downloads
4 Variables, 61 Observations UNF:6:/q/gHl04oSUpBoQqgTjU+w==
This file contains metabolite HMDB IDs and their classification information
Datacsv
Preview "F75_metgroup.tab" Preview "F75_metgroup.tab"
F75_pair_key_pwater.tab
Tabular Data - 3.7 KB
Published Jul 21, 2023
5 Downloads
4 Variables, 140 Observations UNF:6:raHjBCWxUvCHXsWHivRTxw==
This file contains strata key for the case-control matched pairs of the study, mortality outcome, and percent of water content in the corresponding fecal sample.
Datacsv
Preview "F75_pair_key_pwater.tab" Preview "F75_pair_key_pwater.tab"
F75_intestinal_process.R
R Syntax - 13.9 KB
Published Jul 21, 2023
6 Downloads
MD5: 77463eed0e524817891b46f4669777c0
This data preprocessing script was used to prepare data for analyses from raw data. Raw metabolomic values in “F75_admission_fecal_metabolomics.csv” were merged with raw enteropathy markers in “F75_admission_fecal_marker.csv”. Data quality and influential outliers were analyzed and data were processed to produce the “F75_admission_fecal_combined" data file used in analyses
CodeR script
Preview "F75_intestinal_process.R"
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