Replication Data for: Defining the vaccination window for respiratory syncytial virus (RSV) using age-seroprevalence data for children in Kilifi, Kenya

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Replication Data for: Defining the vaccination window for respiratory syncytial virus (RSV) using age-seroprevalence data for children in Kilifi, Kenya
Nyiro, J.U.; Munywoki, P.K.; Nokes, D.J., 2018, "Replication Data for: Defining the vaccination window for respiratory syncytial virus (RSV) using age-seroprevalence data for children in Kilifi, Kenya", https://doi.org/10.7910/DVN/Z8DRSK, Harvard Dataverse, V1, UNF:6:YPD4A23sNBfhF5XA8zCMCQ== [fileUNF]
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Description

Acute respiratory infection (ARI) is a leading cause of morbidity and mortality in children <5 years old worldwide [1], and respiratory syncytial virus (RSV) is the most important viral pathogen responsible for annual bronchiolitis and pneumonia epidemics in these young children [2–5]. Global estimates indicate that RSV may cause about 0.3 million deaths in young children per year and 99% of these occur in low-income countries[1].

To date there are no licensed vaccines for prevention of RSV disease in infants and young children. Some candidate vaccines have shown promising results[6–8]. Most recently, an attenuated vaccine MEDI ΔM2-2, developed by the use of reverse genetics systems has been shown to be highly restricted in replication and more immunogenic in RSV seronegative children than the previous lead live attenuated RSV vaccine candidates [9]. As a result, these findings provide evidence of availability of a promising candidate vaccine for young children and infants in the near future.

The primary target for RSV vaccination is children under 6 months of age; a group highly susceptible to severe RSV disease[10]. However, vaccination of this age group is complicated by the presence of maternal antibodies, among other factors[11]. Assuming the efficacy of a potential vaccine is significantly reduced if administered in the presence of maternal antibodies, it follows that the age of vaccination should be delayed. However, a majority of primary RSV infections are acquired early in life[12] and so delaying vaccination could result in missing out on a large proportion of preventable infections. As such a vaccination window or age should be established such that there is minimal maternal antibody interference and a majority of infections have not occurred.

In this study we present the age-specific prevalence of antibodies to RSV from a rural community at the Kenyan coast. We then develop three nested catalytic models that explore different assumptions on the RSV specific antibody dynamics. Samples were selected randomly from pediatric admissions to a County hospital in coastal Kenya, and screened for antibodies to RSV by ELISA. The data from this study provides basic understanding on natural response to RSV infection and has a bearing on the optimal age of RSV vaccine delivery.

Subject Medicine, Health and Life Sciences
Related Publication Nyiro, J.U., Kombe, I.K., Sande, C.J., Kipkoech, J., Kiyuka, P.K., Onyango, C.O., Munywoki, P.K., Kinyanjui, T.M. and Nokes, D.J., 2017. Defining the vaccination window for respiratory syncytial virus (RSV) using age-seroprevalence data for children in Kilifi, Kenya. PLoS One, 12(5), p.e0177803.doi: 10.1371/journal.pone.0177803
Notes Related Datasets: https://doi.org/10.1371/journal.pone.0177803.s001 (XLS)
Additional information of the analysis: https://doi.org/10.1371/journal.pone.0177803.s002 (DOCX)
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This data is made available under the Creative Commons Attribution 4.0 International (CC BY 4.0) - https://creativecommons.org/licenses/by/4.0/legalcode. Publications based on these data should acknowledge this source by means of bibliographic citations. For more information on these data, please contact the authors: Nyiro, J.U. (JNyiro@kemri-wellcome.org); Munywoki, P.K. (PMunywoki@kemri-wellcome.org); Nokes, D.J. (JNokes@kemri-wellcome.org) or the data governance office via this email address: dgc@kemri-wellcome.org
Publications based on this data collection should acknowledge this source by means of bibliographic citation. To ensure that such source attributions are captured for bibliographic utilities, citations must appear in footnotes or in the reference section of publications. The bibliographic citation for this data collection is: "Nyiro, J.U.; Munywoki, P.K.; Nokes, D.J., 2018, "Replication Data for: Defining the vaccination window for respiratory syncytial virus (RSV) using age-seroprevalence data for children in Kilifi, Kenya", doi:10.7910/DVN/Z8DRSK, Harvard Dataverse,V1"
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