1 to 10 of 11 Results
May 2, 2025
Williams, Tom, 2025, "SPIRIT 2013 Checklist: Hydroxyurea - Pragmatic Reduction In Mortality and Economic burden (H-PRIME): A 2x2x2 factorial randomised open-label trial investigating practical approaches to the treatment of sickle cell disease at four sites in Eastern Uganda: ISRCTN 15724013", https://doi.org/10.7910/DVN/QUGG6P, Harvard Dataverse, V3
Package includes a SPIRIT checklist and Trial assessment schedule. Trial Registration Number: ISRCTN 15724013 |
May 2, 2025
Williams, Tom, 2025, "Extended Data for: Hydroxyurea - Pragmatic Reduction In Mortality and Economic burden (H-PRIME): A 2x2x2 factorial randomised open-label trial investigating practical approaches to the treatment of sickle cell disease at four sites in Eastern Uganda: ISRCTN 15724013", https://doi.org/10.7910/DVN/DKR3LX, Harvard Dataverse, V1
The package contains extended data for the protocol titled "Hydroxyurea - Pragmatic Reduction In Mortality and Economic burden (H-PRIME): A 2x2x2 factorial randomised open-label trial investigating practical approaches to the treatment of sickle cell disease at four sites in Eastern Uganda: ISRCTN 15724013" |
Jun 2, 2023
Opi, Herbert; Ndila, Carolyne M.; Uyoga, Sophie; Macharia, Alex W.; Fennell,Clare; Ochola, Lucy B.; Nyutu,Gideon; Siddondo,Bethsheba R.; Ojal, John; Shebe, Mohammed; Awuondo, Kennedy O.; Mturi, Neema; Peshu, Norbert; Tsofa, Benjamin; Band, Gavin; Maitland, Kathryn; Kwiatkowski, Dominic P.; Rockett, Kirk A.; Williams, Thomas N.; Rowe, J. Alexandra, 2023, "Replication Data for: Non-O ABO blood group genotypes differ in their associations with Plasmodium falciparum rosetting and severe malaria", https://doi.org/10.7910/DVN/A5KILM, Harvard Dataverse, V1
We present here the replication dataset used to generate results for the manuscript titled "Non-O ABO blood group genotypes differ in their associations with Plasmodium falciparum rosetting and severe malaria". The dataset included here comprise of clinical, epidemiological and multiple host genotype (including ABO blood group) data from a cases co... |
Sep 8, 2021
Ndila, Carolyne M.; Nyirongo, Vysaul; Macharia, Alexander W.; Jeffreys, Anna E.; Rowlands, Kate; Hubbart, Christina; Busby, George B. J.; Band, Gavin; Harding, Rosalind; Rockett, Kirk A.; Williams, Thomas N.; the MalariaGEN Consortium, 2020, "Replication Data for: Haplotype heterogeneity and low linkage disequilibrium reduce reliable prediction of genotypes for the ‑α3.7I form of α-thalassaemia using genome-wide microarray data", https://doi.org/10.7910/DVN/YTXAHR, Harvard Dataverse, V4, UNF:6:6YD+L93LLD7FbMgF6sUNIQ== [fileUNF]
This is a replication dataset for the submitted manuscript: "Haplotype heterogeneity and low linkage disequilibrium reduce reliable prediction of genotypes for the α3.7I form of α-thalassaemia using genome-wide microarray data". The dataset contains genotyped α-thalassemia mutations from more than 6,000 individuals from Kilifi, Kenya. These data al... |
Houston, Kirsty A.; Gibb, Jack; Olupot-Olupot, Peter; Obonyo, Nchafatso; Mpoya, Ayub; Nakuya, Margaret; Muhindo, Rita; Uyoga, Sophie; Evans, Jennifer A.; Connon, Roisin; Gibb, Diana M.; George, Elizabeth C.; Maitland, Kathryn, 2021, "Data for: Gastroenteritis aggressive versus slow treatment for rehydration (GASTRO): a phase II rehydration trial for severe dehydration: WHO plan C versus slow rehydration", https://doi.org/10.7910/DVN/UXTBZP, Harvard Dataverse, V1, UNF:6:tTt8SmeSoimg6d2G7FoYfA== [fileUNF]
A multi-centre open-label phase II randomised controlled trial evaluated two rehydration strategies in 122 Ugandan/Kenyan children aged 60 days to 12 years with severe dehydration secondary to gastroenteritis. We compared the safety and efficacy of standard rapid rehydration using Ringer’s lactate (100 ml/kg over 3 h (6 h if < 1 year), incorporatin... |
Jul 5, 2021
Uyoga, Sophie; Adetifa, Ifedayo M.O.; Otiende, Mark; Gitonga, John N.; Mugo, Daisy; Nyagwange, James; Karanja, Henry K.; Tuju, James; Makale, Johnstone; Aman, Rashid; Mwangangi, Mercy; Amoth, Patrick; Kasera, Kadondi; Ng’ang’a, Wangari; Chege, Evelynn; Yegon, Christine; Kithi, Khamisi; Odhiambo, Elizabeth; Rotich, Thomas; Orgut, Irene; Kihara, Sammy; Bottomley, Christian; Kagucia, Eunice W.; Gallagher, Katherine E.; Etyang, Anthony; Voller, Shirine; Lambe,Teresa; Wright, Daniel; Barasa, Edwine; Tsofa, Benjamin; Mwangangi, Joseph; Bejon, Philip; Ochola-Oyier, Lynette I.; Warimwe, George M.; Agweyu, Ambrose; Scott, J. Anthony G., 2021, "Replication Data for: Prevalence of SARS-CoV-2 Antibodies from a one-year National Serosurveillance of Kenyan Blood Transfusion Donors", https://doi.org/10.7910/DVN/3E1YSQ, Harvard Dataverse, V1, UNF:6:Bt/7QJL1Wm92kwX0Odn/UA== [fileUNF]
These data contain anonymised residual donor serum samples used for screening of transfusion transmissible infections collected at the KNBTS regional centres which has been used to compute standardised SARS-CoV-2 seroprevalence by age, sex and region using KNBS population as the standard population. |
Jul 5, 2021
Watson, James A.; Maitland, Kathryn; Williams, Thomas N.; White, Nicholas J., 2021, "Replication Data for: Improving statistical power in severe malaria genetic association studies by augmenting phenotypic precision", https://doi.org/10.7910/DVN/TH8WAW, Harvard Dataverse, V1, UNF:6:mwwyTYMcojPhaZDP4PlXAA== [fileUNF]
This is a replication dataset for the manuscript titled: "Improving statistical power in severe malaria genetic association studies by augmenting phenotypic precision." This dataset contains complete blood count data (platelet counts and total white blood cell counts) for severely ill patients enrolled in either studies of severe malaria or general... |
Jun 7, 2021
Macharia, Alexander W.; Mochamah, George; Makale, Johnstone; Howard, Thad; Mturi, Neema; Olupot-Olupot, Peter; Färnert, Anna; Ware, Russell E.; Williams, Thomas N., 2021, "Replication Data for: A case of β-thalassemia major on the East African Coast", https://doi.org/10.7910/DVN/T90WIG, Harvard Dataverse, V1
This is a replication data package for the manuscript titled: "A case of β-thalassemia major on the East African Coast." |
Macharia, Alex W.; Uyoga, Sophie; Ndila, Carolyne; Nyutu, Gideon; Makale, Johnstone; Tendwa, Metrine; Nyatichi, Emily; Ojal, John; Atkinson, Sarah; Williams, Thomas N., 2021, "Replication Data for: The population dynamics of haemoglobins A, A2, F and S in the context of the haemoglobinopathies HbS and α+thalassaemia in Kenyan infants", https://doi.org/10.7910/DVN/G2Y9JZ, Harvard Dataverse, V1, UNF:6:0rmqiHihDEreCXNEeblqmA== [fileUNF]
This is a replication data package for the paper: "The population dynamics of hemoglobins A, A2, F and S in the context of the hemoglobinopathies HbS and α-thalassemia in Kenyan infants." |
Nyutu, Gideon; Uyoga, Sophie; Williams, Thomas N., 2020, "Replication Data for: The indirect health effects of malaria estimated from health advantages of the sickle cell trait", https://doi.org/10.7910/DVN/OB8FFI, Harvard Dataverse, V2
This is a replication dataset for the paper "Uyoga, S., Macharia, A.W., Ndila, C.M., Nyutu, G., Shebe, M., Awuondo, K.O., Mturi, N., Peshu, N., Tsofa, B., Scott, J.A.G. and Maitland, K., 2019. The indirect health effects of malaria estimated from health advantages of the sickle cell trait. Nature communications, 10(1), pp.1-7." Most estimates of th... |
