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SPIRIT 2013 Checklist: Hydroxyurea - Pragmatic Reduction In Mortality and Economic burden (H-PRIME): A 2x2x2 factorial randomised open-label trial investigating practical approaches to the treatment of sickle cell disease at four sites in Eastern Uganda: ISRCTN 15724013
May 2, 2025
Williams, Tom, 2025, "SPIRIT 2013 Checklist: Hydroxyurea - Pragmatic Reduction In Mortality and Economic burden (H-PRIME): A 2x2x2 factorial randomised open-label trial investigating practical approaches to the treatment of sickle cell disease at four sites in Eastern Uganda: ISRCTN 15724013", https://doi.org/10.7910/DVN/QUGG6P, Harvard Dataverse, V3
Package includes a SPIRIT checklist and Trial assessment schedule. Trial Registration Number: ISRCTN 15724013
pactr.samrc.ac.za_TrialDisplay.aspx_TrialID=25747.pdf
May 2, 2025 - SPIRIT 2013 Checklist: Hydroxyurea - Pragmatic Reduction In Mortality and Economic burden (H-PRIME): A 2x2x2 factorial randomised open-label trial investigating practical approaches to the treatment of sickle cell disease at four sites in Eastern Uganda: ISRCTN 15724013
Adobe PDF - 287.7 KB - MD5: 3c30329ab7845566fcd1f5a766b1e880
PACTR Registration File
Extended Data for: Hydroxyurea - Pragmatic Reduction In Mortality and Economic burden (H-PRIME): A 2x2x2 factorial randomised open-label trial investigating practical approaches to the treatment of sickle cell disease at four sites in Eastern Uganda: ISRCTN 15724013
May 2, 2025
Williams, Tom, 2025, "Extended Data for: Hydroxyurea - Pragmatic Reduction In Mortality and Economic burden (H-PRIME): A 2x2x2 factorial randomised open-label trial investigating practical approaches to the treatment of sickle cell disease at four sites in Eastern Uganda: ISRCTN 15724013", https://doi.org/10.7910/DVN/DKR3LX, Harvard Dataverse, V1
The package contains extended data for the protocol titled "Hydroxyurea - Pragmatic Reduction In Mortality and Economic burden (H-PRIME): A 2x2x2 factorial randomised open-label trial investigating practical approaches to the treatment of sickle cell disease at four sites in Eastern Uganda: ISRCTN 15724013"
101_H-PRIME patient information sheet ΓÇô parents and carers v2.06.docx
May 2, 2025 - Extended Data for: Hydroxyurea - Pragmatic Reduction In Mortality and Economic burden (H-PRIME): A 2x2x2 factorial randomised open-label trial investigating practical approaches to the treatment of sickle cell disease at four sites in Eastern Uganda: ISRCTN 15724013
MS Word - 165.6 KB - MD5: a3e388b1ebfece28d4b38e47d9ae6018
102_H-PRIME TRIAL patient information sheet older children v2.06.docx
May 2, 2025 - Extended Data for: Hydroxyurea - Pragmatic Reduction In Mortality and Economic burden (H-PRIME): A 2x2x2 factorial randomised open-label trial investigating practical approaches to the treatment of sickle cell disease at four sites in Eastern Uganda: ISRCTN 15724013
MS Word - 50.5 KB - MD5: 205b0f38f7a4b77982d3aef0f5c12583
103_H-PRIME consent form for screening v2.06.docx
May 2, 2025 - Extended Data for: Hydroxyurea - Pragmatic Reduction In Mortality and Economic burden (H-PRIME): A 2x2x2 factorial randomised open-label trial investigating practical approaches to the treatment of sickle cell disease at four sites in Eastern Uganda: ISRCTN 15724013
MS Word - 164.6 KB - MD5: 73030510d7d650507b9e1866f1813ef7
104_H-PRIME TRIAL consent form - parents and carers v2.06.docx
May 2, 2025 - Extended Data for: Hydroxyurea - Pragmatic Reduction In Mortality and Economic burden (H-PRIME): A 2x2x2 factorial randomised open-label trial investigating practical approaches to the treatment of sickle cell disease at four sites in Eastern Uganda: ISRCTN 15724013
MS Word - 163.7 KB - MD5: 41d9c14e32a845e764955f5334667d1e
105_H-PRIME TRIAL assent form v2.06.docx
May 2, 2025 - Extended Data for: Hydroxyurea - Pragmatic Reduction In Mortality and Economic burden (H-PRIME): A 2x2x2 factorial randomised open-label trial investigating practical approaches to the treatment of sickle cell disease at four sites in Eastern Uganda: ISRCTN 15724013
MS Word - 164.4 KB - MD5: 1e1a43dded6ac06e350a7d7460f4dc99
106_H-PRIME TRIAL patient information sheet specimen storage v2.06.docx
May 2, 2025 - Extended Data for: Hydroxyurea - Pragmatic Reduction In Mortality and Economic burden (H-PRIME): A 2x2x2 factorial randomised open-label trial investigating practical approaches to the treatment of sickle cell disease at four sites in Eastern Uganda: ISRCTN 15724013
MS Word - 165.2 KB - MD5: 2b4e2b9faef5b6b30101be6a9a0d646a
107_H-PRIME TRIAL consent form specimen storeage v2.06.docx
May 2, 2025 - Extended Data for: Hydroxyurea - Pragmatic Reduction In Mortality and Economic burden (H-PRIME): A 2x2x2 factorial randomised open-label trial investigating practical approaches to the treatment of sickle cell disease at four sites in Eastern Uganda: ISRCTN 15724013
MS Word - 163.0 KB - MD5: a656d060082fdbc8c6b35fd47fd71de4
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