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Replication Data for: Haplotype heterogeneity and low linkage disequilibrium reduce reliable prediction of genotypes for the ‑α3.7I form of α-thalassaemia using genome-wide microarray data
Sep 8, 2021
Ndila, Carolyne M.; Nyirongo, Vysaul; Macharia, Alexander W.; Jeffreys, Anna E.; Rowlands, Kate; Hubbart, Christina; Busby, George B. J.; Band, Gavin; Harding, Rosalind; Rockett, Kirk A.; Williams, Thomas N.; the MalariaGEN Consortium, 2020, "Replication Data for: Haplotype heterogeneity and low linkage disequilibrium reduce reliable prediction of genotypes for the ‑α3.7I form of α-thalassaemia using genome-wide microarray data", https://doi.org/10.7910/DVN/YTXAHR, Harvard Dataverse, V4, UNF:6:6YD+L93LLD7FbMgF6sUNIQ== [fileUNF]
This is a replication dataset for the submitted manuscript: "Haplotype heterogeneity and low linkage disequilibrium reduce reliable prediction of genotypes for the α3.7I form of α-thalassaemia using genome-wide microarray data". The dataset contains genotyped α-thalassemia mutations from more than 6,000 individuals from Kilifi, Kenya. These data al...
Extended_Data_AUG2021.pdf
Sep 8, 2021 - Replication Data for: Haplotype heterogeneity and low linkage disequilibrium reduce reliable prediction of genotypes for the ‑α3.7I form of α-thalassaemia using genome-wide microarray data
Adobe PDF - 5.8 MB - MD5: db5fac954834274ff6df9752f0d6eeb1
Extended Data
README_Ndila_et_al_alpha-thalassemia_in_KENYA_v2.txt
Sep 8, 2021 - Replication Data for: Haplotype heterogeneity and low linkage disequilibrium reduce reliable prediction of genotypes for the ‑α3.7I form of α-thalassaemia using genome-wide microarray data
Plain Text - 9.9 KB - MD5: 1200c17c5676f4c79d59851cd4c25abd
DocumentationReadme file
Underlying_DATA4_description.txt
Sep 8, 2021 - Replication Data for: Haplotype heterogeneity and low linkage disequilibrium reduce reliable prediction of genotypes for the ‑α3.7I form of α-thalassaemia using genome-wide microarray data
Plain Text - 1.1 KB - MD5: e8f9caeb2aaad416b1f18ed1ed96b734
Data descriptorDocumentation
Underlying_data4.tab
Sep 8, 2021 - Replication Data for: Haplotype heterogeneity and low linkage disequilibrium reduce reliable prediction of genotypes for the ‑α3.7I form of α-thalassaemia using genome-wide microarray data
Tab-Separated Values - 13.0 MB - MD5: 32555356014596b586a5a3ffceb4314e
Data
Data for: Gastroenteritis aggressive versus slow treatment for rehydration (GASTRO): a phase II rehydration trial for severe dehydration: WHO plan C versus slow rehydration
Data for: Gastroenteritis aggressive versus slow treatment for rehydration (GASTRO): a phase II rehydration trial for severe dehydration: WHO plan C versus slow rehydration
Aug 25, 2021
Houston, Kirsty A.; Gibb, Jack; Olupot-Olupot, Peter; Obonyo, Nchafatso; Mpoya, Ayub; Nakuya, Margaret; Muhindo, Rita; Uyoga, Sophie; Evans, Jennifer A.; Connon, Roisin; Gibb, Diana M.; George, Elizabeth C.; Maitland, Kathryn, 2021, "Data for: Gastroenteritis aggressive versus slow treatment for rehydration (GASTRO): a phase II rehydration trial for severe dehydration: WHO plan C versus slow rehydration", https://doi.org/10.7910/DVN/UXTBZP, Harvard Dataverse, V1, UNF:6:tTt8SmeSoimg6d2G7FoYfA== [fileUNF]
A multi-centre open-label phase II randomised controlled trial evaluated two rehydration strategies in 122 Ugandan/Kenyan children aged 60 days to 12 years with severe dehydration secondary to gastroenteritis. We compared the safety and efficacy of standard rapid rehydration using Ringer’s lactate (100 ml/kg over 3 h (6 h if < 1 year), incorporatin...
Baseline.tab
Aug 25, 2021 - Data for: Gastroenteritis aggressive versus slow treatment for rehydration (GASTRO): a phase II rehydration trial for severe dehydration: WHO plan C versus slow rehydration
Tabular Data - 27.8 KB - 58 Variables, 122 Observations - UNF:6:re/JVKsqXLaDJtdDgt0oHQ==
DataSTATA v15
This file contains data collected during screening and enrollment, and clinical assessment at admission.
Data Dictionary.pdf
Data Dictionary.pdf
Aug 25, 2021 - Data for: Gastroenteritis aggressive versus slow treatment for rehydration (GASTRO): a phase II rehydration trial for severe dehydration: WHO plan C versus slow rehydration
Adobe PDF - 389.8 KB - MD5: 414e032b94b9b3c8a857f1d4998af6e5
DocumentationVariable Codebook/Data Dictionary
Contains variable descriptions and value labels
During_Admission.tab
Aug 25, 2021 - Data for: Gastroenteritis aggressive versus slow treatment for rehydration (GASTRO): a phase II rehydration trial for severe dehydration: WHO plan C versus slow rehydration
Tabular Data - 193.0 KB - 417 Variables, 122 Observations - UNF:6:GHw8AFkM71T732mYZ6p2ow==
DataSTATA v15
This file contains data from clinical reviews during admission (at 1, 4, 8, 12, 24 and 48 hours after starting fluids) and observations (at 0, 30, 60, 90, 120, 180 minutes and 4, 8, 12, 24 hours after starting fluids), anthropometry measurements (taken daily from admission to day 4) and information collected at discharge.
Fluids.tab
Aug 25, 2021 - Data for: Gastroenteritis aggressive versus slow treatment for rehydration (GASTRO): a phase II rehydration trial for severe dehydration: WHO plan C versus slow rehydration
Tabular Data - 545.9 KB - 49 Variables, 3416 Observations - UNF:6:rijXIl7HAJ0izYEr4i14Eg==
DataSTATA v15
This file is in long format and contains the times rehydration and bolus fluids were given, times of oral intake and urine output, and the fluid prescriptions.
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