Invasive Bacterial Disease Research Group Dataverse

We have had a major input in evaluating the effectiveness and wider impact of the pneumococcal conjugate vaccine (PCV10) in Kenya, including studies of the effect on carriage, invasive disease, burden of pneumonia and pathogen structure. We are expanding our platform of surveillance to incorporate assessments of the safety of EPI vaccines, direct and indirect effects of rotavirus vaccination, and studies of the non-specific effects of vaccination. We will examine the epidemiology of invasive salmonella infection and salmonella carriage in children and adults, and participate in the clinical development of a whole cell pneumococcal vaccine which is serotype independent.

The group is affiliated to the Kemri Wellcome Trust Research Programme and Wellcome Trust. Each dataset has a citation and DOI, facilitating attribution and connection to research publications. For information about the IBD Data Archive, please visit our website http://pcvis.org .

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1 to 10 of 17 Results

Replication Data for: The impact of 10-valent pneumococcal conjugate vaccine on the incidence of admissions to hospital with hypoxaemic and non-hypoxaemic pneumonia in Kenyan children Jun 30, 2025 Haeusler, Ilsa; Scott, J. Anthony G, 2025, "Replication Data for: The impact of 10-valent pneumococcal conjugate vaccine on the incidence of admissions to hospital with hypoxaemic and non-hypoxaemic pneumonia in Kenyan children", https://doi.org/10.7910/DVN/FDB1ON, Harvard Dataverse, V2, UNF:6:5bvk0nFZfQlv4au/QEgOYQ== [fileUNF] This is a replication dataset for the manuscript titled: "The impact of 10-valent pneumococcal conjugate vaccine on the incidence of admissions to hospital with hypoxaemic and non-hypoxaemic pneumonia in Kenyan children." The Kilifi Health and Demographic Surveillance System (KHDSS) operates within Kilifi County, Kenya. Household surveys record bir...
Replication Data for: Active vaccine safety surveillance in sub-Saharan Africa: Experience from a prospective cohort event monitoring study of COVID-19 vaccines in Kenya. Feb 24, 2025 Odhiambo, Don B.; Akech, Donald; Karia, Boniface; Kimani, Makobu; Sang, Samuel; Sigilai, Antipa; Voller, Shirine; Mataza, Christine; Mang’ong’o, David; Jalang’o, Rose; Mandale, Martha; Etyang, Anthony O.; Scott, Anthony G.; Agweyu, Ambrose; Kagucia, E. Wangeci, 2025, "Replication Data for: Active vaccine safety surveillance in sub-Saharan Africa: Experience from a prospective cohort event monitoring study of COVID-19 vaccines in Kenya.", https://doi.org/10.7910/DVN/15QZIF, Harvard Dataverse, V1, UNF:6:empS9SZrZiS2xzgKvUuD7w== [fileUNF] This is a replication dataset for the manuscript titled: "Active vaccine safety surveillance in sub-Saharan Africa: Experience from a prospective cohort event monitoring study of COVID-19 vaccines in Kenya." This study conducted in Kilifi county, Kenya involved active safety surveillance of COVID-19 vaccines administered routinely at the participat...
Replication Data for: Prospective Clinical Surveillance for Severe Acute Respiratory Illness in Kenyan Hospitals during the COVID-19 pandemic Oct 25, 2024 Lucinde, Ruth K.; Gathuri, Henry, 2024, "Replication Data for: Prospective Clinical Surveillance for Severe Acute Respiratory Illness in Kenyan Hospitals during the COVID-19 pandemic", https://doi.org/10.7910/DVN/1QXHPK, Harvard Dataverse, V1, UNF:6:KjXDJmYzsCnarQdkk4JHow== [fileUNF] This is a replication dataset for the submitted manuscript titled: "Prospective Clinical Surveillance for Severe Acute Respiratory Illness in Kenyan Hospitals during the COVID-19 pandemic." The data was generated by a prospective longitudinal hospital-based sentinel surveillance between May 2020 and December 2022 at 16 public hospitals in Kenya. Th...
Replication Data for: Effect of Previous Exposure to Malaria on Blood Pressure in Kilifi, Kenya: A Mendelian Randomization Study Aug 8, 2023 Etyang, Anthony O.; Kapesa, Sailoki; Odipo, Emily; Bauni, Evasius; Kyobutungi, Catherine; Abdalla, Marwah; Mutner, Paul; Musani, Solomon K.; Macharia, Alex; Williams, Thomas N.; Cruickshank, J Kennedy; Smeeth, Liam; Scott, J Anthony G., 2023, "Replication Data for: Effect of Previous Exposure to Malaria on Blood Pressure in Kilifi, Kenya: A Mendelian Randomization Study", https://doi.org/10.7910/DVN/NCFR6X, Harvard Dataverse, V1 This is a replication dataset for the research paper: "Effect of Previous Exposure to Malaria on Blood Pressure in Kilifi, Kenya: A Mendelian Randomization Study published in Journal of the American Heart Association.
Replication Data for: SARS-CoV-2 seroprevalence and implications for population immunity: Evidence from two Health and Demographic Surveillance System sites in Kenya, February-December 2022 Jun 19, 2023 Karia, Boniface; Kagucia, E. Wangeci, 2022, "Replication Data for: SARS-CoV-2 seroprevalence and implications for population immunity: Evidence from two Health and Demographic Surveillance System sites in Kenya, February-December 2022", https://doi.org/10.7910/DVN/L4AUEG, Harvard Dataverse, V2, UNF:6:/AzedQo06sVkNbPGEqgI8w== [fileUNF] This is a replication dataset underlying the findings described in the manuscript entitled "SARS-CoV-2 seroprevalence and implications for population immunity: Evidence from two Health and Demographic Surveillance System sites in Kenya, February - December 2022" and submitted to Influenza and Other Respiratory Viruses.
Replication Data for: Impact of COVID-19 on mortality in coastal Kenya: a longitudinal open cohort study Mar 31, 2023 Otiende, Mark; Nyaguara, Amek; Bottomley, Christian; Walumbe, David; Mochamah, George; Amadi, David; Nyundo, Christopher; Kagucia, Eunice; Etyang, Anthony; Adetifa, Ifedayo; Brand, Sam; Maitha, Eric; Chondo, Elwyn; Nzomo, Eddy; Aman, Rashid; Mwangangi, Mercy; Amoth, Patrick; Kasera, Kadondi; Ng'ang'a, Wangari; Barasa,Edwin; Tsofa, Benjamin; Mwangangi, Joseph; Bejon, Philip; Agweyu, Ambrose; Williams, Thomas N.; J. Anthony G. Scott, 2023, "Replication Data for: Impact of COVID-19 on mortality in coastal Kenya: a longitudinal open cohort study", https://doi.org/10.7910/DVN/HAGRAK, Harvard Dataverse, V1 This is a replication dataset for the manuscript titled: "Impact of COVID-19 on mortality in coastal Kenya: a longitudinal open cohort study". These datasets contain aggregated mortality data from the Kilifi HDSS used to describe the impact of COVID-19 on all-cause mortality from 2020-2022.
Replication Data for: Anti-Severe Acute Respiratory Syndrome Coronavirus 2 Immunoglobulin G Antibody Seroprevalence Among Truck Drivers and Assistants in Kenya Oct 6, 2022 Kagucia, E. Wangeci; Karia, Boniface, 2022, "Replication Data for: Anti-Severe Acute Respiratory Syndrome Coronavirus 2 Immunoglobulin G Antibody Seroprevalence Among Truck Drivers and Assistants in Kenya", https://doi.org/10.7910/DVN/VTTV63, Harvard Dataverse, V2, UNF:6:apP+4G5wJSBe7DybwhuqRQ== [fileUNF] This is a replication dataset for the publication titled: "Anti-Severe Acute Respiratory Syndrome Coronavirus 2 Immunoglobulin G Antibody Seroprevalence Among Truck Drivers and Assistants in Kenya." The serosurvey was conducted at three sites, one in Kilifi County in South-Eastern Kenya, and two in Busia County in Western Kenya. The dataset contain...
Replication Data for: SARS-CoV-2 Seroprevalence in three Kenyan Health and Demographic Surveillance Sites, December 2020-May 2021 Jun 9, 2022 Otiende, Mark; Etyang, Anthony A, 2022, "Replication Data for: SARS-CoV-2 Seroprevalence in three Kenyan Health and Demographic Surveillance Sites, December 2020-May 2021", https://doi.org/10.7910/DVN/TG31BU, Harvard Dataverse, V1, UNF:6:nVkOvdQ+DSkeJCXFYxYetw== [fileUNF] This is a replication dataset for the manuscript title: "SARS-CoV-2 Seroprevalence in three Kenyan Health and Demographic Surveillance Sites, December 2020-May 2021" submitted to PLOS Global Public Health.
Replication Data for: Seroprevalence of anti–SARS-CoV-2 antibodies in women attending antenatal care in eastern Ethiopia Jun 9, 2021 Assefa, Nega; Demissie, Lemma; Teklemarriam, Zelalem; Oundo, Joseph; Madrid, Lola; Dessie, Yadeta; Scott, J. Anthony G., 2021, "Replication Data for: Seroprevalence of anti–SARS-CoV-2 antibodies in women attending antenatal care in eastern Ethiopia", https://doi.org/10.7910/DVN/XIWCXN, Harvard Dataverse, V1, UNF:6:JUfob81W4Xlp55LDQAGhsQ== [fileUNF] Data from a Sero-survey done in Ethiopia. Participants were mothers going for their first ANC visit. Serology results alongside other demographic and clinical information included in the dataset
The Effect of Fractional Doses of Pneumococcal Conjugate Vaccines on Immunogenicity and Carriage in Kenyan Infants Jun 9, 2021 Scott, J. Anthony G.; Gallagher, Katherine, 2021, "The Effect of Fractional Doses of Pneumococcal Conjugate Vaccines on Immunogenicity and Carriage in Kenyan Infants", https://doi.org/10.7910/DVN/DJ054F, Harvard Dataverse, V1 Before the introduction of pneumonia vaccines in 2000, between 700,000 - 1 million children died each year as a result of infection with the bacteria Streptococcus pneumoniae and the resulting diseases, namely, meningitis, sepsis and pneumonia. Most of the deaths were in Africa and Asia. Where the vaccines have been introduced, they have been highl...

Replication Data for: The impact of 10-valent pneumococcal conjugate vaccine on the incidence of admissions to hospital with hypoxaemic and non-hypoxaemic pneumonia in Kenyan children

Jun 30, 2025

Haeusler, Ilsa; Scott, J. Anthony G, 2025, "Replication Data for: The impact of 10-valent pneumococcal conjugate vaccine on the incidence of admissions to hospital with hypoxaemic and non-hypoxaemic pneumonia in Kenyan children", https://doi.org/10.7910/DVN/FDB1ON, Harvard Dataverse, V2, UNF:6:5bvk0nFZfQlv4au/QEgOYQ== [fileUNF]

This is a replication dataset for the manuscript titled: "The impact of 10-valent pneumococcal conjugate vaccine on the incidence of admissions to hospital with hypoxaemic and non-hypoxaemic pneumonia in Kenyan children." The Kilifi Health and Demographic Surveillance System (KHDSS) operates within Kilifi County, Kenya. Household surveys record bir...

Replication Data for: Active vaccine safety surveillance in sub-Saharan Africa: Experience from a prospective cohort event monitoring study of COVID-19 vaccines in Kenya.

Feb 24, 2025

Odhiambo, Don B.; Akech, Donald; Karia, Boniface; Kimani, Makobu; Sang, Samuel; Sigilai, Antipa; Voller, Shirine; Mataza, Christine; Mang’ong’o, David; Jalang’o, Rose; Mandale, Martha; Etyang, Anthony O.; Scott, Anthony G.; Agweyu, Ambrose; Kagucia, E. Wangeci, 2025, "Replication Data for: Active vaccine safety surveillance in sub-Saharan Africa: Experience from a prospective cohort event monitoring study of COVID-19 vaccines in Kenya.", https://doi.org/10.7910/DVN/15QZIF, Harvard Dataverse, V1, UNF:6:empS9SZrZiS2xzgKvUuD7w== [fileUNF]

This is a replication dataset for the manuscript titled: "Active vaccine safety surveillance in sub-Saharan Africa: Experience from a prospective cohort event monitoring study of COVID-19 vaccines in Kenya." This study conducted in Kilifi county, Kenya involved active safety surveillance of COVID-19 vaccines administered routinely at the participat...

Replication Data for: Prospective Clinical Surveillance for Severe Acute Respiratory Illness in Kenyan Hospitals during the COVID-19 pandemic

Oct 25, 2024

Lucinde, Ruth K.; Gathuri, Henry, 2024, "Replication Data for: Prospective Clinical Surveillance for Severe Acute Respiratory Illness in Kenyan Hospitals during the COVID-19 pandemic", https://doi.org/10.7910/DVN/1QXHPK, Harvard Dataverse, V1, UNF:6:KjXDJmYzsCnarQdkk4JHow== [fileUNF]

This is a replication dataset for the submitted manuscript titled: "Prospective Clinical Surveillance for Severe Acute Respiratory Illness in Kenyan Hospitals during the COVID-19 pandemic." The data was generated by a prospective longitudinal hospital-based sentinel surveillance between May 2020 and December 2022 at 16 public hospitals in Kenya. Th...

Replication Data for: Effect of Previous Exposure to Malaria on Blood Pressure in Kilifi, Kenya: A Mendelian Randomization Study

Aug 8, 2023

Etyang, Anthony O.; Kapesa, Sailoki; Odipo, Emily; Bauni, Evasius; Kyobutungi, Catherine; Abdalla, Marwah; Mutner, Paul; Musani, Solomon K.; Macharia, Alex; Williams, Thomas N.; Cruickshank, J Kennedy; Smeeth, Liam; Scott, J Anthony G., 2023, "Replication Data for: Effect of Previous Exposure to Malaria on Blood Pressure in Kilifi, Kenya: A Mendelian Randomization Study", https://doi.org/10.7910/DVN/NCFR6X, Harvard Dataverse, V1

This is a replication dataset for the research paper: "Effect of Previous Exposure to Malaria on Blood Pressure in Kilifi, Kenya: A Mendelian Randomization Study published in Journal of the American Heart Association.

Replication Data for: SARS-CoV-2 seroprevalence and implications for population immunity: Evidence from two Health and Demographic Surveillance System sites in Kenya, February-December 2022

Jun 19, 2023

Karia, Boniface; Kagucia, E. Wangeci, 2022, "Replication Data for: SARS-CoV-2 seroprevalence and implications for population immunity: Evidence from two Health and Demographic Surveillance System sites in Kenya, February-December 2022", https://doi.org/10.7910/DVN/L4AUEG, Harvard Dataverse, V2, UNF:6:/AzedQo06sVkNbPGEqgI8w== [fileUNF]

This is a replication dataset underlying the findings described in the manuscript entitled "SARS-CoV-2 seroprevalence and implications for population immunity: Evidence from two Health and Demographic Surveillance System sites in Kenya, February - December 2022" and submitted to Influenza and Other Respiratory Viruses.

Replication Data for: Impact of COVID-19 on mortality in coastal Kenya: a longitudinal open cohort study

Mar 31, 2023

Otiende, Mark; Nyaguara, Amek; Bottomley, Christian; Walumbe, David; Mochamah, George; Amadi, David; Nyundo, Christopher; Kagucia, Eunice; Etyang, Anthony; Adetifa, Ifedayo; Brand, Sam; Maitha, Eric; Chondo, Elwyn; Nzomo, Eddy; Aman, Rashid; Mwangangi, Mercy; Amoth, Patrick; Kasera, Kadondi; Ng'ang'a, Wangari; Barasa,Edwin; Tsofa, Benjamin; Mwangangi, Joseph; Bejon, Philip; Agweyu, Ambrose; Williams, Thomas N.; J. Anthony G. Scott, 2023, "Replication Data for: Impact of COVID-19 on mortality in coastal Kenya: a longitudinal open cohort study", https://doi.org/10.7910/DVN/HAGRAK, Harvard Dataverse, V1

This is a replication dataset for the manuscript titled: "Impact of COVID-19 on mortality in coastal Kenya: a longitudinal open cohort study". These datasets contain aggregated mortality data from the Kilifi HDSS used to describe the impact of COVID-19 on all-cause mortality from 2020-2022.

Replication Data for: Anti-Severe Acute Respiratory Syndrome Coronavirus 2 Immunoglobulin G Antibody Seroprevalence Among Truck Drivers and Assistants in Kenya

Oct 6, 2022

Kagucia, E. Wangeci; Karia, Boniface, 2022, "Replication Data for: Anti-Severe Acute Respiratory Syndrome Coronavirus 2 Immunoglobulin G Antibody Seroprevalence Among Truck Drivers and Assistants in Kenya", https://doi.org/10.7910/DVN/VTTV63, Harvard Dataverse, V2, UNF:6:apP+4G5wJSBe7DybwhuqRQ== [fileUNF]

This is a replication dataset for the publication titled: "Anti-Severe Acute Respiratory Syndrome Coronavirus 2 Immunoglobulin G Antibody Seroprevalence Among Truck Drivers and Assistants in Kenya." The serosurvey was conducted at three sites, one in Kilifi County in South-Eastern Kenya, and two in Busia County in Western Kenya. The dataset contain...

Replication Data for: SARS-CoV-2 Seroprevalence in three Kenyan Health and Demographic Surveillance Sites, December 2020-May 2021

Jun 9, 2022

Otiende, Mark; Etyang, Anthony A, 2022, "Replication Data for: SARS-CoV-2 Seroprevalence in three Kenyan Health and Demographic Surveillance Sites, December 2020-May 2021", https://doi.org/10.7910/DVN/TG31BU, Harvard Dataverse, V1, UNF:6:nVkOvdQ+DSkeJCXFYxYetw== [fileUNF]

This is a replication dataset for the manuscript title: "SARS-CoV-2 Seroprevalence in three Kenyan Health and Demographic Surveillance Sites, December 2020-May 2021" submitted to PLOS Global Public Health.

Replication Data for: Seroprevalence of anti–SARS-CoV-2 antibodies in women attending antenatal care in eastern Ethiopia

Jun 9, 2021

Assefa, Nega; Demissie, Lemma; Teklemarriam, Zelalem; Oundo, Joseph; Madrid, Lola; Dessie, Yadeta; Scott, J. Anthony G., 2021, "Replication Data for: Seroprevalence of anti–SARS-CoV-2 antibodies in women attending antenatal care in eastern Ethiopia", https://doi.org/10.7910/DVN/XIWCXN, Harvard Dataverse, V1, UNF:6:JUfob81W4Xlp55LDQAGhsQ== [fileUNF]

Data from a Sero-survey done in Ethiopia. Participants were mothers going for their first ANC visit. Serology results alongside other demographic and clinical information included in the dataset

The Effect of Fractional Doses of Pneumococcal Conjugate Vaccines on Immunogenicity and Carriage in Kenyan Infants

Jun 9, 2021

Scott, J. Anthony G.; Gallagher, Katherine, 2021, "The Effect of Fractional Doses of Pneumococcal Conjugate Vaccines on Immunogenicity and Carriage in Kenyan Infants", https://doi.org/10.7910/DVN/DJ054F, Harvard Dataverse, V1

Before the introduction of pneumonia vaccines in 2000, between 700,000 - 1 million children died each year as a result of infection with the bacteria Streptococcus pneumoniae and the resulting diseases, namely, meningitis, sepsis and pneumonia. Most of the deaths were in Africa and Asia. Where the vaccines have been introduced, they have been highl...

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