Clinical Research

CHAIN Network Dataverse

Featured Dataverses

In order to use this feature you must have at least one published or linked dataverse.

Publish Dataverse

Are you sure you want to publish your dataverse? Once you do so it must remain published.

Publish Dataverse

This dataverse cannot be published because the dataverse it is in has not been published.

Delete Dataverse

Are you sure you want to delete your dataverse? You cannot undelete this dataverse.

11 to 20 of 33 Results

Replication Data for: Intestinal Disturbances Associated with Mortality of Children with Complicated Severe Malnutrition Jul 21, 2023 Wen, Bijun; Farooqui,Amber; Bourdon, Celine; Ngari,Moses M.; Chimwezi, Emmanuel; Thitiri, Johnstone; Mwalekwa,Laura; Walson,Judd L.; Voskuijl,Wieger; Berkley, James A.; Bandsma,Robert H.J., 2023, "Replication Data for: Intestinal Disturbances Associated with Mortality of Children with Complicated Severe Malnutrition", https://doi.org/10.7910/DVN/I4EYDR, Harvard Dataverse, V1, UNF:6:91IeQamdBuBKIzOXzgZqIQ== [fileUNF] This is a replication dataset for the manuscript titled: "Replication Data for: Intestinal Disturbances Associated with Mortality of Children with Complicated Severe Malnutrition." This is data is from a case-control study nested within the F75 intervention trial. By comparing the fecal metabolomic profiles and enteropathy markers between cases (ch...
TRUE-1: Trial of Repurposed Unithiol for snakebite Envenoming Phase 1 (Safety, Tolerability, Pharmacokinetics and Pharmacodynamics in Healthy Kenyan Adults) Oct 6, 2022 Abouyannis, Michael, 2022, "TRUE-1: Trial of Repurposed Unithiol for snakebite Envenoming Phase 1 (Safety, Tolerability, Pharmacokinetics and Pharmacodynamics in Healthy Kenyan Adults)", https://doi.org/10.7910/DVN/LJOYSO, Harvard Dataverse, V3 This package contains DMP, SAP and DSMB charter for the TRUE-1: Trial of Repurposed Unithiol for snakebite Envenoming Phase 1 (Safety, Tolerability, Pharmacokinetics and Pharmacodynamics in Healthy Kenyan Adults).
Data for: CHAIN neurodevelopment sub-study Jul 7, 2022 - CHAIN Network Dataverse van den Heuvel, Meta, 2022, "Data for: CHAIN neurodevelopment sub-study", https://doi.org/10.7910/DVN/VYJEJK, Harvard Dataverse, V1 The dataset contains all data used to analyze the neurodevelopment sub-study that was run between 01/01/2017 and 01/01/2019. This was a multi-site longitudinal study that involved 3 sites in 3 countries. The study compared antibiotic used to treat children with severe acute malnutrition.Participant demographic, clinical, social, and laboratory data...
Replication Data for: Inpatient and post-discharge mortality among young infants admitted to a rural Kenyan hospital. Jun 9, 2022 Ngari, Moses M.; Talbert, Alison W.; Ouma, Nelson; Otiende, Mark; Berkley, James A., 2022, "Replication Data for: Inpatient and post-discharge mortality among young infants admitted to a rural Kenyan hospital.", https://doi.org/10.7910/DVN/0XJVFX, Harvard Dataverse, V1, UNF:6:tGXhhS7F+3WT5rEQrZ5dbQ== [fileUNF] This dataset contains data used for a secondary analysis of Pediatric admissions at Kilifi County Hospital (KCH) from 2009 to 2019 linked to the Kilifi Health Demographic Surveillance System (KHDSS). The objective of the study was to describe admission trends and measure inpatient and post-discharge mortality and its associated exposures, including...
Replication Data for: Detection of pathogens associated with early-onset neonatal sepsis in cord blood at birth using quantitative PCR Dec 2, 2021 Obiero, Christina W.; Gumbi, Wilson; Mwakio, Stella; Mwangudzah, Hope; Seale, Anna C.; Taniuchi, Mami; Liu, Jie; Houpt,Eric; Berkley, James A., 2021, "Replication Data for: Detection of pathogens associated with early-onset neonatal sepsis in cord blood at birth using quantitative PCR", https://doi.org/10.7910/DVN/FXKGRB, Harvard Dataverse, V2, UNF:6:1y774FFEonin35nFyxDD2A== [fileUNF] This is a replication dataset for the manuscript titled:"Detection of pathogens associated with early-onset neonatal sepsis in cord blood at birth using quantitative PCR" submitted to Welcome Open Research journal. There is paucity of data on the aetiology of early onset sepsis despite its associated significant mortality and neurological impairmen...
Data for: First Line Antimicrobials in Children With Complicated Severe Acute Malnutrition (FLACSAM) Nov 24, 2021 Berkely, James A., 2021, "Data for: First Line Antimicrobials in Children With Complicated Severe Acute Malnutrition (FLACSAM)", https://doi.org/10.7910/DVN/D6ZJAG, Harvard Dataverse, V1 This dataset contains FLACSAM Trial Protocol and Statistical Analysis Plan (SAP). The study was a multi-site longitudinal trial that involved 4 sites in 2 countries. During the study, participant demographic, clinical, social, and laboratory data was collected at various timepoints depending on a predetermined study activity schedule. The trial is...
Data for: Arterolane–piperaquine–mefloquine versus arterolane–piperaquine and artemether–lumefantrine in the treatment of uncomplicated Plasmodium falciparum malaria in Kenyan children: a single-centre, open-label, randomised, non-inferiority trial Nov 23, 2021 Hamaluba, Mainga; van der Pluijm, Rob W.; Weya, Joseph; Njuguna, Patricia; Ngama, Mwanajuma; Kalume, Peter; Mwambingu, Gabriel; Ngetsa, Caroline; Wambua, Juliana; Boga, Mwanamvua; Mturi, Neema; Lal, Altaf A.; Khuroo, Arshad; Taylor, Walter R.J.; Gonçalves, Sónia; Miotto, Olivo; Dhorda, Mehul; Mutinda, Brian; Mukaka, Mavuto; Waithira, Naomi; Hoglund, Richard M.; Imwong, Mallika; Tarning, Joel; Day, Nicholas P.J.; White, Nicholas J.; Bejon, Philip; Dondorp, Arjen M., 2021, "Data for: Arterolane–piperaquine–mefloquine versus arterolane–piperaquine and artemether–lumefantrine in the treatment of uncomplicated Plasmodium falciparum malaria in Kenyan children: a single-centre, open-label, randomised, non-inferiority trial", https://doi.org/10.7910/DVN/AJTQUO, Harvard Dataverse, V1, UNF:6:sw9vELH54Z98BR/YYmYd5w== [fileUNF] This data was generated by an open-label randomised controlled clinical trial compared the safety, tolerability, therapeutic efficacy and pharmacokinetics and pharmacodynamics of arterolane-piperaquine, arterolane-piperaquine plus mefloquine versus artemether-lumefantrine.in children with uncomplicated falciparum malaria in Kilifi, Kenya. The study...
Replication Data for: Biomarkers of post-discharge mortality among children with complicated severe acute malnutrition Oct 22, 2021 Njunge, James M.; Gwela, Agnes; Kibinge, Nelson K.; Ngari, Moses M.; Nyamako, Lydia; Nyatichi, Emily; Thitiri, Johnstone; Gonzales, Gerard B.; Bandsma, Robert H.J.; Walson, Judd; Gitau, Evelyn; Berkley, James A., 2021, "Replication Data for: Biomarkers of post-discharge mortality among children with complicated severe acute malnutrition", https://doi.org/10.7910/DVN/CEQ1OL, Harvard Dataverse, V1, UNF:6:k27M1p2R9dL6pZ6YDJLFfQ== [fileUNF] This was a nested case control study within a clinical trial (NCT00934492) that tested the efficacy of daily co‐trimoxazole prophylaxis in reducing post‐discharge mortality among HIV‐uninfected children aged 2-59 months hospitalised with CSM in two urban (Mombasa and Nairobi) and two rural (Kilifi and Malindi) hospitals in Kenya. We investigated me...
Replication Data for: Albumin-dependent and independent mechanisms in the syndrome of kwashiorkor Jun 2, 2021 Gonzales, Gerard B.; Njunge, James M.; Gichuki, Bonface M.; Wen, Bijun; Ngari, Moses M.; Potani, Isabel; Thitiri, Johnstone; Laukens, Debby; Vanmassenhove, Jill; Voskuijl, Wieger; Bandsma, Robert H.J.; Berkley, James A., 2021, "Replication Data for: Albumin-dependent and independent mechanisms in the syndrome of kwashiorkor", https://doi.org/10.7910/DVN/NQCN2E, Harvard Dataverse, V1, UNF:6:9mBhiyYv1F5GG/snTGNJaA== [fileUNF] This is a replication dataset for the manuscript titled: "Albumin-dependent and independent mechanisms in the syndrome of kwashiorkor." Our aim was to determine albumin-independent differences in pathophysiology between Severe wasting and kwashiorkor to inform targeted prevention and treatment strategies . We used the F75 reformulation clinical tra...
Replication Data for: Monitoring Anthropometry and Mortality Risk in Low Birthweight Infants: a birth cohort study in Burkina Faso Apr 6, 2021 Mwangome, Martha; Ngari, Moses; Bwahere, Paluku; Kabore, Patrick; McGrath, Marie; Berkley, James A., 2021, "Replication Data for: Monitoring Anthropometry and Mortality Risk in Low Birthweight Infants: a birth cohort study in Burkina Faso", https://doi.org/10.7910/DVN/APNI8G, Harvard Dataverse, V1 This is a replication dataset for the manuscript titled: "Monitoring Anthropometry and Mortality Risk in Low Birthweight Infants: a birth cohort study in Burkina Faso submitted to Gates Open Research." We have included in this data package the analysis code used in generating the reported findings and a STROBE Checklist.

Replication Data for: Intestinal Disturbances Associated with Mortality of Children with Complicated Severe Malnutrition

Jul 21, 2023

Wen, Bijun; Farooqui,Amber; Bourdon, Celine; Ngari,Moses M.; Chimwezi, Emmanuel; Thitiri, Johnstone; Mwalekwa,Laura; Walson,Judd L.; Voskuijl,Wieger; Berkley, James A.; Bandsma,Robert H.J., 2023, "Replication Data for: Intestinal Disturbances Associated with Mortality of Children with Complicated Severe Malnutrition", https://doi.org/10.7910/DVN/I4EYDR, Harvard Dataverse, V1, UNF:6:91IeQamdBuBKIzOXzgZqIQ== [fileUNF]

This is a replication dataset for the manuscript titled: "Replication Data for: Intestinal Disturbances Associated with Mortality of Children with Complicated Severe Malnutrition." This is data is from a case-control study nested within the F75 intervention trial. By comparing the fecal metabolomic profiles and enteropathy markers between cases (ch...

TRUE-1: Trial of Repurposed Unithiol for snakebite Envenoming Phase 1 (Safety, Tolerability, Pharmacokinetics and Pharmacodynamics in Healthy Kenyan Adults)

Oct 6, 2022

Abouyannis, Michael, 2022, "TRUE-1: Trial of Repurposed Unithiol for snakebite Envenoming Phase 1 (Safety, Tolerability, Pharmacokinetics and Pharmacodynamics in Healthy Kenyan Adults)", https://doi.org/10.7910/DVN/LJOYSO, Harvard Dataverse, V3

This package contains DMP, SAP and DSMB charter for the TRUE-1: Trial of Repurposed Unithiol for snakebite Envenoming Phase 1 (Safety, Tolerability, Pharmacokinetics and Pharmacodynamics in Healthy Kenyan Adults).

Data for: CHAIN neurodevelopment sub-study

Jul 7, 2022 - CHAIN Network Dataverse

van den Heuvel, Meta, 2022, "Data for: CHAIN neurodevelopment sub-study", https://doi.org/10.7910/DVN/VYJEJK, Harvard Dataverse, V1

The dataset contains all data used to analyze the neurodevelopment sub-study that was run between 01/01/2017 and 01/01/2019. This was a multi-site longitudinal study that involved 3 sites in 3 countries. The study compared antibiotic used to treat children with severe acute malnutrition.Participant demographic, clinical, social, and laboratory data...

Replication Data for: Inpatient and post-discharge mortality among young infants admitted to a rural Kenyan hospital.

Jun 9, 2022

Ngari, Moses M.; Talbert, Alison W.; Ouma, Nelson; Otiende, Mark; Berkley, James A., 2022, "Replication Data for: Inpatient and post-discharge mortality among young infants admitted to a rural Kenyan hospital.", https://doi.org/10.7910/DVN/0XJVFX, Harvard Dataverse, V1, UNF:6:tGXhhS7F+3WT5rEQrZ5dbQ== [fileUNF]

This dataset contains data used for a secondary analysis of Pediatric admissions at Kilifi County Hospital (KCH) from 2009 to 2019 linked to the Kilifi Health Demographic Surveillance System (KHDSS). The objective of the study was to describe admission trends and measure inpatient and post-discharge mortality and its associated exposures, including...

Replication Data for: Detection of pathogens associated with early-onset neonatal sepsis in cord blood at birth using quantitative PCR

Dec 2, 2021

Obiero, Christina W.; Gumbi, Wilson; Mwakio, Stella; Mwangudzah, Hope; Seale, Anna C.; Taniuchi, Mami; Liu, Jie; Houpt,Eric; Berkley, James A., 2021, "Replication Data for: Detection of pathogens associated with early-onset neonatal sepsis in cord blood at birth using quantitative PCR", https://doi.org/10.7910/DVN/FXKGRB, Harvard Dataverse, V2, UNF:6:1y774FFEonin35nFyxDD2A== [fileUNF]

This is a replication dataset for the manuscript titled:"Detection of pathogens associated with early-onset neonatal sepsis in cord blood at birth using quantitative PCR" submitted to Welcome Open Research journal. There is paucity of data on the aetiology of early onset sepsis despite its associated significant mortality and neurological impairmen...

Data for: First Line Antimicrobials in Children With Complicated Severe Acute Malnutrition (FLACSAM)

Nov 24, 2021

Berkely, James A., 2021, "Data for: First Line Antimicrobials in Children With Complicated Severe Acute Malnutrition (FLACSAM)", https://doi.org/10.7910/DVN/D6ZJAG, Harvard Dataverse, V1

This dataset contains FLACSAM Trial Protocol and Statistical Analysis Plan (SAP). The study was a multi-site longitudinal trial that involved 4 sites in 2 countries. During the study, participant demographic, clinical, social, and laboratory data was collected at various timepoints depending on a predetermined study activity schedule. The trial is...

Data for: Arterolane–piperaquine–mefloquine versus arterolane–piperaquine and artemether–lumefantrine in the treatment of uncomplicated Plasmodium falciparum malaria in Kenyan children: a single-centre, open-label, randomised, non-inferiority trial

Nov 23, 2021

Hamaluba, Mainga; van der Pluijm, Rob W.; Weya, Joseph; Njuguna, Patricia; Ngama, Mwanajuma; Kalume, Peter; Mwambingu, Gabriel; Ngetsa, Caroline; Wambua, Juliana; Boga, Mwanamvua; Mturi, Neema; Lal, Altaf A.; Khuroo, Arshad; Taylor, Walter R.J.; Gonçalves, Sónia; Miotto, Olivo; Dhorda, Mehul; Mutinda, Brian; Mukaka, Mavuto; Waithira, Naomi; Hoglund, Richard M.; Imwong, Mallika; Tarning, Joel; Day, Nicholas P.J.; White, Nicholas J.; Bejon, Philip; Dondorp, Arjen M., 2021, "Data for: Arterolane–piperaquine–mefloquine versus arterolane–piperaquine and artemether–lumefantrine in the treatment of uncomplicated Plasmodium falciparum malaria in Kenyan children: a single-centre, open-label, randomised, non-inferiority trial", https://doi.org/10.7910/DVN/AJTQUO, Harvard Dataverse, V1, UNF:6:sw9vELH54Z98BR/YYmYd5w== [fileUNF]

This data was generated by an open-label randomised controlled clinical trial compared the safety, tolerability, therapeutic efficacy and pharmacokinetics and pharmacodynamics of arterolane-piperaquine, arterolane-piperaquine plus mefloquine versus artemether-lumefantrine.in children with uncomplicated falciparum malaria in Kilifi, Kenya. The study...

Replication Data for: Biomarkers of post-discharge mortality among children with complicated severe acute malnutrition

Oct 22, 2021

Njunge, James M.; Gwela, Agnes; Kibinge, Nelson K.; Ngari, Moses M.; Nyamako, Lydia; Nyatichi, Emily; Thitiri, Johnstone; Gonzales, Gerard B.; Bandsma, Robert H.J.; Walson, Judd; Gitau, Evelyn; Berkley, James A., 2021, "Replication Data for: Biomarkers of post-discharge mortality among children with complicated severe acute malnutrition", https://doi.org/10.7910/DVN/CEQ1OL, Harvard Dataverse, V1, UNF:6:k27M1p2R9dL6pZ6YDJLFfQ== [fileUNF]

This was a nested case control study within a clinical trial (NCT00934492) that tested the efficacy of daily co‐trimoxazole prophylaxis in reducing post‐discharge mortality among HIV‐uninfected children aged 2-59 months hospitalised with CSM in two urban (Mombasa and Nairobi) and two rural (Kilifi and Malindi) hospitals in Kenya. We investigated me...

Replication Data for: Albumin-dependent and independent mechanisms in the syndrome of kwashiorkor

Jun 2, 2021

Gonzales, Gerard B.; Njunge, James M.; Gichuki, Bonface M.; Wen, Bijun; Ngari, Moses M.; Potani, Isabel; Thitiri, Johnstone; Laukens, Debby; Vanmassenhove, Jill; Voskuijl, Wieger; Bandsma, Robert H.J.; Berkley, James A., 2021, "Replication Data for: Albumin-dependent and independent mechanisms in the syndrome of kwashiorkor", https://doi.org/10.7910/DVN/NQCN2E, Harvard Dataverse, V1, UNF:6:9mBhiyYv1F5GG/snTGNJaA== [fileUNF]

This is a replication dataset for the manuscript titled: "Albumin-dependent and independent mechanisms in the syndrome of kwashiorkor." Our aim was to determine albumin-independent differences in pathophysiology between Severe wasting and kwashiorkor to inform targeted prevention and treatment strategies . We used the F75 reformulation clinical tra...

Replication Data for: Monitoring Anthropometry and Mortality Risk in Low Birthweight Infants: a birth cohort study in Burkina Faso

Apr 6, 2021

Mwangome, Martha; Ngari, Moses; Bwahere, Paluku; Kabore, Patrick; McGrath, Marie; Berkley, James A., 2021, "Replication Data for: Monitoring Anthropometry and Mortality Risk in Low Birthweight Infants: a birth cohort study in Burkina Faso", https://doi.org/10.7910/DVN/APNI8G, Harvard Dataverse, V1

This is a replication dataset for the manuscript titled: "Monitoring Anthropometry and Mortality Risk in Low Birthweight Infants: a birth cohort study in Burkina Faso submitted to Gates Open Research." We have included in this data package the analysis code used in generating the reported findings and a STROBE Checklist.

Add Data

Share Dataverse

Link Dataverse

Reset Modifications