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1 to 10 of 33 Results

Replication Data for: Genomic epidemiology of sporadic and outbreak associated infant Klebsiella pneumoniae sepsis in Kenyan hospitals. Jul 2, 2025 Amulele, Anne, 2025, "Replication Data for: Genomic epidemiology of sporadic and outbreak associated infant Klebsiella pneumoniae sepsis in Kenyan hospitals.", https://doi.org/10.7910/DVN/0XINJB, Harvard Dataverse, V1, UNF:6:Ue4qHToAWM4xphmHHC8fBA== [fileUNF] This is a replication dataset for the manuscript titled: "Genomic epidemiology of sporadic and outbreak associated infant Klebsiella pneumoniae sepsis in Kenyan hospitals." This dataset comprised clinical and genome sequence data from two sources; A neonatal bacteriaemia (≤ 28 days old) study (NeoBAC) conducted in three hospitals in Nairobi, Kiambu...
Data for Neonatal Bacteraemia at level 4 county Hospitals in Kenya (NeoBAC) May 13, 2025 Tigoi, Caroline; Ngao,Narshion; Kahindi, Eunice, 2025, "Data for Neonatal Bacteraemia at level 4 county Hospitals in Kenya (NeoBAC)", https://doi.org/10.7910/DVN/5MYMR3, Harvard Dataverse, V1, UNF:6:Xey29dft1yXeGILF2vY4eg== [fileUNF] The NeoBAC study aimed to investigate how often bacterial blood stream infections occur in newborns, which bacteria cause them, and whether they are resistant to particular antibiotics. As part of routine clinical care, all newborn babies had a blood sample taken for culture to see if any bacteria could be grown. After the sample was taken, the bab...
Gastroenteritis: Rehydration of children with Severe Acute Malnutrition (GASTROSAM) Apr 29, 2025 Maitland, Kathryn, 2025, "Gastroenteritis: Rehydration of children with Severe Acute Malnutrition (GASTROSAM)", https://doi.org/10.7910/DVN/DXH6FK, Harvard Dataverse, V1 The package contains Gastroenteritis: Rehydration of children with Severe Acute Malnutrition (GASTROSAM) Trial SAP. The trial has been registered on ISRCTN (registry identifier 76149273), ICREC (identifier 18IC4427), and PACTR (identifier 202103852542919).
Replication Data for: Role of inflammation in impairing post-hospital discharge growth among underweight children hospitalised with acute illness in sub-Saharan Africa and south Asia Mar 27, 2025 Njunge, James M., 2024, "Replication Data for: Role of inflammation in impairing post-hospital discharge growth among underweight children hospitalised with acute illness in sub-Saharan Africa and south Asia", https://doi.org/10.7910/DVN/TBQYSF, Harvard Dataverse, V3 This is a replication dataset for the manuscript titled: "Role of inflammation in impairing post-hospital discharge growth among underweight children hospitalised with acute illness in sub-Saharan Africa and south Asia. The datasets were generated through the CHAIN network study as detailed in the manuscript (https://bmjopen.bmj.com/content/9/5/e02...
Replication Data for: Plasma lipopolysaccharide levels, microbiota and biomarkers of enteric dysfunction predict mortality in acutely ill children in sub-Saharan Africa and South Asia Oct 22, 2024 Allen, Chris A.D.; Ghate, Arya, 2024, "Replication Data for: Plasma lipopolysaccharide levels, microbiota and biomarkers of enteric dysfunction predict mortality in acutely ill children in sub-Saharan Africa and South Asia", https://doi.org/10.7910/DVN/EJA4F6, Harvard Dataverse, V1 This is a replication dataset for the submitted manuscript titled: "Plasma lipopolysaccharide levels, microbiota and biomarkers of enteric dysfunction predict mortality in acutely ill children in sub-Saharan Africa and South Asia. Sub-Saharan Africa and South Asia account for a disproportionately high share of global under-five mortality. Acute inf...
Replication Data for: Systemic biological mechanisms underpin poor post-discharge growth among severely wasted children with HIV Jul 1, 2024 Mudibo, Evans O.; Bogaert, Jasper; Tigoi, Caroline; Ngari, Moses M.; Singa, Benson O.; Lancioni, Christina L.; Diallo, Abdoulaye Hama; Mbale, Emmie; Thitiri, Johnstone; Timbwa, Molline; Omer, Elisha; Ngao, Narshion; Musyimi,Robert; Kahindi, Eunice; Mupere, Ezekiel; Mukisa,John; Bamouni, Roseline Maïmouna; Bandsma, Robert H.J.; Kelly, Paul; Prendergast, Andrew J.; McGrath, Christine J.; Tickell, Kirkby D.; Walson, Judd L.; Berkley, James A.; Njunge, James M.; Gonzales, Gerard Bryan., 2024, "Replication Data for: Systemic biological mechanisms underpin poor post-discharge growth among severely wasted children with HIV", https://doi.org/10.7910/DVN/D8HZLJ, Harvard Dataverse, V2 This is a replication dataset for the manuscript titled: "Systemic biological mechanisms underpin poor post-discharge growth among severely wasted children with HIV." In sub-Saharan Africa, a proportion of children hospitalised with severe malnutrition (SM) also have HIV infection (HIV-SM). Children with HIV-SM have poorer clinical outcomes than ch...
Data for: Pancreatic Enzymes and Bile Acids: A Non-Antibiotic approach to Treat Intestinal Dysbiosis in Acutely Ill Severely Malnourished Children Jun 13, 2024 - CHAIN Network Dataverse Berkley, James A.; Bandsma,Robert H.J.; Ngao, Narshion M.; Ngari, Moses M., 2024, "Data for: Pancreatic Enzymes and Bile Acids: A Non-Antibiotic approach to Treat Intestinal Dysbiosis in Acutely Ill Severely Malnourished Children", https://doi.org/10.7910/DVN/J6YSV8, Harvard Dataverse, V2 This dataset contains clinical information for 429 participants who were enrolled in the PBSAM trial (see protocol for more details). Participants were enrolled after meeting an inclusion criteria into the study of having at least 2 severe characteristics for an acute illness and with a severe acute malnutrition diagnosis. They were then followed u...
Data for: Non- inferiority fractional-doses trial for yellow fever vaccine (NIFTY Trial) $Data for: Non- inferiority fractional-doses trial for yellow fever vaccine (NIFTY Trial)$ Feb 1, 2024 Warimwe, George M.; Kimathi, Derick; Cheruiyot, Stanley; Bejon, Philip, 2024, "Data for: Non- inferiority fractional-doses trial for yellow fever vaccine (NIFTY Trial)", https://doi.org/10.7910/DVN/YBRX8I, Harvard Dataverse, V2, UNF:6:Zw1UGT8lKZDq60RW8Com4Q== [fileUNF] The NIFTY trial sought to determine whether reducing the dosage of the vaccine can provide the same protection to the standard dosage given in Kenyan and Ugandan adults and children. The trial is registered at ClinicalTrials.gov. ID: NCT04059471. This dataset relates to a trial to determine the safety and immune response elicited by the reduced dos...
Replication Data for: Inpatient and post-discharge mortality among children with anaemia and malaria parasitaemia in coastal Kenya: a cohort study Jan 15, 2024 Ngari, Moses M.; Ouma, Nelson; Nyaguara, Amek; Berkley, James A., 2024, "Replication Data for: Inpatient and post-discharge mortality among children with anaemia and malaria parasitaemia in coastal Kenya: a cohort study", https://doi.org/10.7910/DVN/RLSBMD, Harvard Dataverse, V1, UNF:6:Zv55IlqpXIndyawNusIJVg== [fileUNF] This is a replication dataset for the manuscript: "Inpatient and post-discharge mortality among children with anaemia and malaria parasitaemia in coastal Kenya: a cohort study." This was a secondary analysis of Pediatric admissions at Kilifi County Hospital (KCH) from 2010 to 2019 linked to the Kilifi Health Demographic Surveillance System (KHDSS)....
Data for: A Phase 1b, open-label, age de-escalation, dose-escalation study to evaluate the safety and immunogenicity of different doses of a candidate malaria vaccine; adjuvanted R21(R21/MM) in adults, young children and infants in Kilifi, Kenya Sep 15, 2023 Sang, Samuel; Datoo, Mehreen; Otieno, Edward; Muiruri, Charles; Gathuri, Emmaloise; Ngoto,Omar; Musembi, Janet; Bellamy, Duncan; Provstgaard-Morys, Samuel; Stockdale, Lisa; Aboagye, Jeremy; Woods, Daniel; Lawrie, Alison; Roberts, Rachel; Keter, Kelvias; Kimani, Domtila; Ndungu, Francis; Kapulu, Melissa; Njau, Irene; Orindi, Benedict; Ewer, Katie; Hill, Adrian V. S.; Bejon, Philip; Hamaluba, Mainga, 2023, "Data for: A Phase 1b, open-label, age de-escalation, dose-escalation study to evaluate the safety and immunogenicity of different doses of a candidate malaria vaccine; adjuvanted R21(R21/MM) in adults, young children and infants in Kilifi, Kenya", https://doi.org/10.7910/DVN/IRGZ35, Harvard Dataverse, V5, UNF:6:8VbuHGi8Xr05EETTLqzF9g== [fileUNF] In the era of anti-malaria drug resistance and resistance to insecticide treated bed nets, there is an urgent need for a highly efficacious vaccine. We evaluated a candidate malaria vaccine incorporating the antigen R21 (part of the P. falciparum circumsporozoite malaria antigen co-expressed with hepatitis B antigen plus an adjuvant to boost the im...

Replication Data for: Genomic epidemiology of sporadic and outbreak associated infant Klebsiella pneumoniae sepsis in Kenyan hospitals.

Jul 2, 2025

Amulele, Anne, 2025, "Replication Data for: Genomic epidemiology of sporadic and outbreak associated infant Klebsiella pneumoniae sepsis in Kenyan hospitals.", https://doi.org/10.7910/DVN/0XINJB, Harvard Dataverse, V1, UNF:6:Ue4qHToAWM4xphmHHC8fBA== [fileUNF]

This is a replication dataset for the manuscript titled: "Genomic epidemiology of sporadic and outbreak associated infant Klebsiella pneumoniae sepsis in Kenyan hospitals." This dataset comprised clinical and genome sequence data from two sources; A neonatal bacteriaemia (≤ 28 days old) study (NeoBAC) conducted in three hospitals in Nairobi, Kiambu...

Data for Neonatal Bacteraemia at level 4 county Hospitals in Kenya (NeoBAC)

May 13, 2025

Tigoi, Caroline; Ngao,Narshion; Kahindi, Eunice, 2025, "Data for Neonatal Bacteraemia at level 4 county Hospitals in Kenya (NeoBAC)", https://doi.org/10.7910/DVN/5MYMR3, Harvard Dataverse, V1, UNF:6:Xey29dft1yXeGILF2vY4eg== [fileUNF]

The NeoBAC study aimed to investigate how often bacterial blood stream infections occur in newborns, which bacteria cause them, and whether they are resistant to particular antibiotics. As part of routine clinical care, all newborn babies had a blood sample taken for culture to see if any bacteria could be grown. After the sample was taken, the bab...

Gastroenteritis: Rehydration of children with Severe Acute Malnutrition (GASTROSAM)

Apr 29, 2025

Maitland, Kathryn, 2025, "Gastroenteritis: Rehydration of children with Severe Acute Malnutrition (GASTROSAM)", https://doi.org/10.7910/DVN/DXH6FK, Harvard Dataverse, V1

The package contains Gastroenteritis: Rehydration of children with Severe Acute Malnutrition (GASTROSAM) Trial SAP. The trial has been registered on ISRCTN (registry identifier 76149273), ICREC (identifier 18IC4427), and PACTR (identifier 202103852542919).

Replication Data for: Role of inflammation in impairing post-hospital discharge growth among underweight children hospitalised with acute illness in sub-Saharan Africa and south Asia

Mar 27, 2025

Njunge, James M., 2024, "Replication Data for: Role of inflammation in impairing post-hospital discharge growth among underweight children hospitalised with acute illness in sub-Saharan Africa and south Asia", https://doi.org/10.7910/DVN/TBQYSF, Harvard Dataverse, V3

This is a replication dataset for the manuscript titled: "Role of inflammation in impairing post-hospital discharge growth among underweight children hospitalised with acute illness in sub-Saharan Africa and south Asia. The datasets were generated through the CHAIN network study as detailed in the manuscript (https://bmjopen.bmj.com/content/9/5/e02...

Replication Data for: Plasma lipopolysaccharide levels, microbiota and biomarkers of enteric dysfunction predict mortality in acutely ill children in sub-Saharan Africa and South Asia

Oct 22, 2024

Allen, Chris A.D.; Ghate, Arya, 2024, "Replication Data for: Plasma lipopolysaccharide levels, microbiota and biomarkers of enteric dysfunction predict mortality in acutely ill children in sub-Saharan Africa and South Asia", https://doi.org/10.7910/DVN/EJA4F6, Harvard Dataverse, V1

This is a replication dataset for the submitted manuscript titled: "Plasma lipopolysaccharide levels, microbiota and biomarkers of enteric dysfunction predict mortality in acutely ill children in sub-Saharan Africa and South Asia. Sub-Saharan Africa and South Asia account for a disproportionately high share of global under-five mortality. Acute inf...

Replication Data for: Systemic biological mechanisms underpin poor post-discharge growth among severely wasted children with HIV

Jul 1, 2024

Mudibo, Evans O.; Bogaert, Jasper; Tigoi, Caroline; Ngari, Moses M.; Singa, Benson O.; Lancioni, Christina L.; Diallo, Abdoulaye Hama; Mbale, Emmie; Thitiri, Johnstone; Timbwa, Molline; Omer, Elisha; Ngao, Narshion; Musyimi,Robert; Kahindi, Eunice; Mupere, Ezekiel; Mukisa,John; Bamouni, Roseline Maïmouna; Bandsma, Robert H.J.; Kelly, Paul; Prendergast, Andrew J.; McGrath, Christine J.; Tickell, Kirkby D.; Walson, Judd L.; Berkley, James A.; Njunge, James M.; Gonzales, Gerard Bryan., 2024, "Replication Data for: Systemic biological mechanisms underpin poor post-discharge growth among severely wasted children with HIV", https://doi.org/10.7910/DVN/D8HZLJ, Harvard Dataverse, V2

This is a replication dataset for the manuscript titled: "Systemic biological mechanisms underpin poor post-discharge growth among severely wasted children with HIV." In sub-Saharan Africa, a proportion of children hospitalised with severe malnutrition (SM) also have HIV infection (HIV-SM). Children with HIV-SM have poorer clinical outcomes than ch...

Data for: Pancreatic Enzymes and Bile Acids: A Non-Antibiotic approach to Treat Intestinal Dysbiosis in Acutely Ill Severely Malnourished Children

Jun 13, 2024 - CHAIN Network Dataverse

Berkley, James A.; Bandsma,Robert H.J.; Ngao, Narshion M.; Ngari, Moses M., 2024, "Data for: Pancreatic Enzymes and Bile Acids: A Non-Antibiotic approach to Treat Intestinal Dysbiosis in Acutely Ill Severely Malnourished Children", https://doi.org/10.7910/DVN/J6YSV8, Harvard Dataverse, V2

This dataset contains clinical information for 429 participants who were enrolled in the PBSAM trial (see protocol for more details). Participants were enrolled after meeting an inclusion criteria into the study of having at least 2 severe characteristics for an acute illness and with a severe acute malnutrition diagnosis. They were then followed u...

Data for: Non- inferiority fractional-doses trial for yellow fever vaccine (NIFTY Trial)

$Data for: Non- inferiority fractional-doses trial for yellow fever vaccine (NIFTY Trial)$

Feb 1, 2024

Warimwe, George M.; Kimathi, Derick; Cheruiyot, Stanley; Bejon, Philip, 2024, "Data for: Non- inferiority fractional-doses trial for yellow fever vaccine (NIFTY Trial)", https://doi.org/10.7910/DVN/YBRX8I, Harvard Dataverse, V2, UNF:6:Zw1UGT8lKZDq60RW8Com4Q== [fileUNF]

The NIFTY trial sought to determine whether reducing the dosage of the vaccine can provide the same protection to the standard dosage given in Kenyan and Ugandan adults and children. The trial is registered at ClinicalTrials.gov. ID: NCT04059471. This dataset relates to a trial to determine the safety and immune response elicited by the reduced dos...

Replication Data for: Inpatient and post-discharge mortality among children with anaemia and malaria parasitaemia in coastal Kenya: a cohort study

Jan 15, 2024

Ngari, Moses M.; Ouma, Nelson; Nyaguara, Amek; Berkley, James A., 2024, "Replication Data for: Inpatient and post-discharge mortality among children with anaemia and malaria parasitaemia in coastal Kenya: a cohort study", https://doi.org/10.7910/DVN/RLSBMD, Harvard Dataverse, V1, UNF:6:Zv55IlqpXIndyawNusIJVg== [fileUNF]

This is a replication dataset for the manuscript: "Inpatient and post-discharge mortality among children with anaemia and malaria parasitaemia in coastal Kenya: a cohort study." This was a secondary analysis of Pediatric admissions at Kilifi County Hospital (KCH) from 2010 to 2019 linked to the Kilifi Health Demographic Surveillance System (KHDSS)....

Data for: A Phase 1b, open-label, age de-escalation, dose-escalation study to evaluate the safety and immunogenicity of different doses of a candidate malaria vaccine; adjuvanted R21(R21/MM) in adults, young children and infants in Kilifi, Kenya

Sep 15, 2023

Sang, Samuel; Datoo, Mehreen; Otieno, Edward; Muiruri, Charles; Gathuri, Emmaloise; Ngoto,Omar; Musembi, Janet; Bellamy, Duncan; Provstgaard-Morys, Samuel; Stockdale, Lisa; Aboagye, Jeremy; Woods, Daniel; Lawrie, Alison; Roberts, Rachel; Keter, Kelvias; Kimani, Domtila; Ndungu, Francis; Kapulu, Melissa; Njau, Irene; Orindi, Benedict; Ewer, Katie; Hill, Adrian V. S.; Bejon, Philip; Hamaluba, Mainga, 2023, "Data for: A Phase 1b, open-label, age de-escalation, dose-escalation study to evaluate the safety and immunogenicity of different doses of a candidate malaria vaccine; adjuvanted R21(R21/MM) in adults, young children and infants in Kilifi, Kenya", https://doi.org/10.7910/DVN/IRGZ35, Harvard Dataverse, V5, UNF:6:8VbuHGi8Xr05EETTLqzF9g== [fileUNF]

In the era of anti-malaria drug resistance and resistance to insecticide treated bed nets, there is an urgent need for a highly efficacious vaccine. We evaluated a candidate malaria vaccine incorporating the antigen R21 (part of the P. falciparum circumsporozoite malaria antigen co-expressed with hepatitis B antigen plus an adjuvant to boost the im...

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