The Malaria Vaccine Implementation Programme (MVIP), coordinated by WHO, was designed to address several outstanding questions related to the public health use of the RTS,S vaccine. Specifically, the MVIP assessed the feasibility of administering the recommended 4 doses of the vaccine in children; the vaccine’s potential role in reducing childhood deaths; and its safety in the context of routine use. Findings from the MVIP launched sub-nationally by the Ministries of Health in Ghana, Kenya, and Malawi in 2019, formed a major contribution to the full evidence review and recommendation for the RTS,S malaria vaccine in 2021 by WHO’s advisory bodies on immunization (SAGE) and malaria (MPAG). The pilot implementations of the RTS,S vaccine was recommended by the WHO in 2016 and ended in December 2023.

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Jun 17, 2025
Mwapasa, Victor; Asante, Kwaku Poku; Milligan, Paul; Akech, Samuel; ODURO, ABRAHAM; Mathanga, Don; Fogelson, Ari; Kwambai, Titus K; Hamel, Mary J; Kapito-Tembo, Atupele; Gyan, thomas; Westercamp, Nelli; Okine, Rafiq; Moore, Kerryn; Pellaux-Furrer E; Stanley, Christopher C.; Ansong, Daniel; Kariuki, Simon; Njuguna, Patricia; Mvalo, Tisungane; Welaga, Paul; Otienoc, Lucas; Snell, Paul; Schellenberg, David; Chimala, Alfred; Afari, Edwin; Bejon, Philip; Maleta, Kenneth; Agbenyega, Tsiri; Snow, Robert; Zulu, Madalitso D; Odei-Lartey, Eliezer; Chinkhumba, Jobiba; Samuels, Aaron; Malaria Vaccine Program Evaluation Partners, 2025, "Replication Data for: The impact of introducing the RTS,S/AS01E malaria vaccine delivered through routine immunization programmes on mortality in young children: 46-month evaluation of cluster-randomized deployment of the vaccine in Ghana, Kenya and Malawi", https://doi.org/10.7910/DVN/CONGVG, Harvard Dataverse, V1, UNF:6:DtHso3dqYTdRT17HBcH+qA== [fileUNF]
This is a replication dataset for the manuscript titled: "The impact of introducing the RTS,S/AS01E malaria vaccine delivered through routine immunization programmes on mortality in young children: 46-month evaluation of cluster-randomized deployment of the vaccine in Ghana, Kenya and Malawi."
Feb 4, 2025
Asante, Kwaku Poku; Oduro, Abraham; Welega,Paul; Ansong, Daniel; Odei-Lartey, Eliezer; Gyan, Thomas; Gyaase, Stephaney; Sarfo, Augustine; Samuels, Aaron; Westercamp, Nelli; Akech, Samuel; Kwambai, Titus; Khazenzi, Cynthia; Milligan, Paul; Snell, Paul; Moore, Kerryn; Fogelson, Ari; Schellenberg, David; Hamel, Mary; Okine, Rafiq; Mathanga, Don; Mwapasa, Victor; Kapito, Atupele; Mvalo, Tisungane; Msuku, Harrison; Stanley, Christopher; Njuguna, patricia; Kariuki, Simon; Otieno, Lucas; Chimala, Alfred; Afari, Edwin A.; Bejon, Philip; Maleta, Kenneth; Agbenyega, Tsiri; Snow, Robert W.; Zulu, Madaliso; Chinkhumba, Jobiba; Chinkumba, Jobiba; Abubakari, Sulemana Watara; Akumani, Albert; Adu-Gyasi, Dennis; Agbokey, Francis; Amenga-Etego, Seeba; Buabeng, Patrick; Awini, Elizabeth; Sylverken, Justice; Kampim, Aaron; Koram, Kwadwo A .; Hodgson, Abraham; Binka, Fred N.; Tweneboah, Peter Ofori; Ondiegi, Bella; Seda, Brian; Akach, Dorcas; Orwa, Gordon; Nyang’au, Isabella; Odunga, Oscar; Gumba, Francis; Copeland, Nathanial; Mumo, Eda; Musa, Monica; English, Mike; Haji, Adam; Njoroge, Josephine; Msuku, Harrison; Samuel, Vincent; Mariko, Hillary Topazian; Juliano, Jon; Msumba, Lusungu; Mungwira, Randy George; Zimba, Boston Edward; Desai, Meghna; Furrer, Eliane; Aponte, John; Alonso, Pedro; Sillah, Jackson Sophianu; Kalu, Akpaka A., 2024, "Replication Data for: Feasibility, safety, and impact of the RTS,S/AS01E malaria vaccine when implemented through national immunisation programmes: evaluation of cluster-randomised introduction of the vaccine in Ghana, Kenya, and Malawi", https://doi.org/10.7910/DVN/VOZU4T, Harvard Dataverse, V4, UNF:6:/+G0PtDyx5s/wAy7F34XMg== [fileUNF]
This is a replication dataset for the research publication titled: "Feasibility, safety, and impact of the RTS,S/AS01E malaria vaccine when implemented through national immunisation programmes: evaluation of cluster-randomised introduction of the vaccine in Ghana, Kenya, and Malawi."
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