The Malaria Vaccine Implementation Programme (MVIP), coordinated by WHO, was designed to address several outstanding questions related to the public health use of the RTS,S vaccine. Specifically, the MVIP assessed the feasibility of administering the recommended 4 doses of the vaccine in children; the vaccine’s potential role in reducing childhood deaths; and its safety in the context of routine use. Findings from the MVIP launched sub-nationally by the Ministries of Health in Ghana, Kenya, and Malawi in 2019, formed a major contribution to the full evidence review and recommendation for the RTS,S malaria vaccine in 2021 by WHO’s advisory bodies on immunization (SAGE) and malaria (MPAG). The pilot implementations of the RTS,S vaccine was recommended by the WHO in 2016 and ended in December 2023.

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cluster_list_all_coded_es-1.tab
Jun 17, 2025 - Replication Data for: The impact of introducing the RTS,S/AS01E malaria vaccine delivered through routine immunization programmes on mortality in young children: 46-month evaluation of cluster-randomized deployment of the vaccine in Ghana, Kenya and Malawi
Tabular Data - 18.3 KB - 5 Variables, 632 Observations - UNF:6:WYZCPHU6nWoMnicN3AU36w==
DataStata (.dta)
list of the clusters and sex/eligibility categories, in the mortality study
cluster_list_all_coded_es.tab
Jun 17, 2025 - Replication Data for: The impact of introducing the RTS,S/AS01E malaria vaccine delivered through routine immunization programmes on mortality in young children: 46-month evaluation of cluster-randomized deployment of the vaccine in Ghana, Kenya and Malawi
Tabular Data - 17.1 KB - 5 Variables, 632 Observations - UNF:6:WYZCPHU6nWoMnicN3AU36w==
DataStata (.dta)
list of the clusters and sex/eligibility categories, in the mortality study
cluster_list_hosp_coded_grp-1.tab
Jun 17, 2025 - Replication Data for: The impact of introducing the RTS,S/AS01E malaria vaccine delivered through routine immunization programmes on mortality in young children: 46-month evaluation of cluster-randomized deployment of the vaccine in Ghana, Kenya and Malawi
Tabular Data - 4.2 KB - 4 Variables, 154 Observations - UNF:6:3i4Vs5PdZhyOndkdd/7fCw==
DataStata (.dta)
list of the clusters and eligibility categories, for clusters in the sentinel hospital surveillance
cluster_list_hosp_coded_grp.tab
Jun 17, 2025 - Replication Data for: The impact of introducing the RTS,S/AS01E malaria vaccine delivered through routine immunization programmes on mortality in young children: 46-month evaluation of cluster-randomized deployment of the vaccine in Ghana, Kenya and Malawi
Tabular Data - 3.6 KB - 4 Variables, 154 Observations - UNF:6:3i4Vs5PdZhyOndkdd/7fCw==
csv fileData
list of the clusters and eligibility categories, for clusters in the sentinel hospital surveillance
m46_deaths_archive.tab
Jun 17, 2025 - Replication Data for: The impact of introducing the RTS,S/AS01E malaria vaccine delivered through routine immunization programmes on mortality in young children: 46-month evaluation of cluster-randomized deployment of the vaccine in Ghana, Kenya and Malawi
Tabular Data - 2.9 MB - 22 Variables, 33546 Observations - UNF:6:SlHxfPDuTFcvGvJEJqgDVw==
DataStata (.dta)
M46deaths_data.tab
Jun 17, 2025 - Replication Data for: The impact of introducing the RTS,S/AS01E malaria vaccine delivered through routine immunization programmes on mortality in young children: 46-month evaluation of cluster-randomized deployment of the vaccine in Ghana, Kenya and Malawi
Tabular Data - 1.9 MB - 22 Variables, 33546 Observations - UNF:6:SlHxfPDuTFcvGvJEJqgDVw==
csv fileData
contains the mortality data
M46hosp_data.tab
Jun 17, 2025 - Replication Data for: The impact of introducing the RTS,S/AS01E malaria vaccine delivered through routine immunization programmes on mortality in young children: 46-month evaluation of cluster-randomized deployment of the vaccine in Ghana, Kenya and Malawi
Tabular Data - 4.1 MB - 30 Variables, 58004 Observations - UNF:6:qh98cBr1wPbwkc9Tuyj8Uw==
csv fileData
contains the hospital admissions data
m46_sentinel_archive.tab
Jun 17, 2025 - Replication Data for: The impact of introducing the RTS,S/AS01E malaria vaccine delivered through routine immunization programmes on mortality in young children: 46-month evaluation of cluster-randomized deployment of the vaccine in Ghana, Kenya and Malawi
Tabular Data - 6.7 MB - 30 Variables, 58004 Observations - UNF:6:ILlsW8YKFv1nlHnpV5YmcQ==
DataStata (.dta)
MVIP_M46_Variable_Codebook.xlsx
Jun 17, 2025 - Replication Data for: The impact of introducing the RTS,S/AS01E malaria vaccine delivered through routine immunization programmes on mortality in young children: 46-month evaluation of cluster-randomized deployment of the vaccine in Ghana, Kenya and Malawi
MS Excel Spreadsheet - 25.8 KB - MD5: 2301c330c856607316f456a20e4ef8f2
DocumentationVariable Codebook/Data Dictionary
Contains variable descriptions and value labels
pm_m46_deaths_rr.do
Jun 17, 2025 - Replication Data for: The impact of introducing the RTS,S/AS01E malaria vaccine delivered through routine immunization programmes on mortality in young children: 46-month evaluation of cluster-randomized deployment of the vaccine in Ghana, Kenya and Malawi
Stata Syntax - 4.7 KB - MD5: cd6fd791a32a62c3c63cb9d975d4a8e9
CodeSTATA do file
generates the estimates of mortality rate ratios for each analysis population
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