The Malaria Vaccine Implementation Programme (MVIP), coordinated by WHO, was designed to address several outstanding questions related to the public health use of the RTS,S vaccine. Specifically, the MVIP assessed the feasibility of administering the recommended 4 doses of the vaccine in children; the vaccine’s potential role in reducing childhood deaths; and its safety in the context of routine use. Findings from the MVIP launched sub-nationally by the Ministries of Health in Ghana, Kenya, and Malawi in 2019, formed a major contribution to the full evidence review and recommendation for the RTS,S malaria vaccine in 2021 by WHO’s advisory bodies on immunization (SAGE) and malaria (MPAG). The pilot implementations of the RTS,S vaccine was recommended by the WHO in 2016 and ended in December 2023.

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11 to 20 of 24 Results
pm_m46_hosp_rr.do
Jun 17, 2025 - Replication Data for: The impact of introducing the RTS,S/AS01E malaria vaccine delivered through routine immunization programmes on mortality in young children: 46-month evaluation of cluster-randomized deployment of the vaccine in Ghana, Kenya and Malawi
Stata Syntax - 4.2 KB - MD5: 1406de413097dbabd1966224f45f4f56
CodeSTATA do file
generates the estimates of rate ratios for hospital outcomes for the safety and impact populations
pm_m46_hosp_rr_sm.do
Jun 17, 2025 - Replication Data for: The impact of introducing the RTS,S/AS01E malaria vaccine delivered through routine immunization programmes on mortality in young children: 46-month evaluation of cluster-randomized deployment of the vaccine in Ghana, Kenya and Malawi
Stata Syntax - 4.4 KB - MD5: a47d490e9a86b406ccaf97b04f07973a
CodeSTATA do file
generates the rate ratios for severe malaria, for each analysis population
base_and_midline_data_dictionary.xlsx
Feb 4, 2025 - Replication Data for: Feasibility, safety, and impact of the RTS,S/AS01E malaria vaccine when implemented through national immunisation programmes: evaluation of cluster-randomised introduction of the vaccine in Ghana, Kenya, and Malawi
MS Excel Spreadsheet - 10.7 KB - MD5: ac4ffe51e85ad69c0253dfd293d0c248
Variable Codebook/Data Dictionary
mvip_m24_baseline.tab
Jan 22, 2025 - Replication Data for: Feasibility, safety, and impact of the RTS,S/AS01E malaria vaccine when implemented through national immunisation programmes: evaluation of cluster-randomised introduction of the vaccine in Ghana, Kenya, and Malawi
Tabular Data - 908.5 KB - 16 Variables, 17512 Observations - UNF:6:aiVorUshbvUqZfvZYbdidQ==
.csvData
mvip_m24_midline.tab
Jan 22, 2025 - Replication Data for: Feasibility, safety, and impact of the RTS,S/AS01E malaria vaccine when implemented through national immunisation programmes: evaluation of cluster-randomised introduction of the vaccine in Ghana, Kenya, and Malawi
Tabular Data - 1.1 MB - 25 Variables, 17791 Observations - UNF:6:uStsfjF7oOtOhXKiKfF3hw==
.csvData
cluster_list_all_coded_es.tab
May 13, 2024 - Replication Data for: Feasibility, safety, and impact of the RTS,S/AS01E malaria vaccine when implemented through national immunisation programmes: evaluation of cluster-randomised introduction of the vaccine in Ghana, Kenya, and Malawi
Tabular Data - 17.1 KB - 5 Variables, 632 Observations - UNF:6:IyM+ARa8+wLVjf+5+XhCTw==
.csvData
List of all cluster/eligibility/sex combinations (used to assign zero counts to those cluster/eligibility/sex categories that did not report any deaths)
cluster_list_hosp_coded_e.tab
May 13, 2024 - Replication Data for: Feasibility, safety, and impact of the RTS,S/AS01E malaria vaccine when implemented through national immunisation programmes: evaluation of cluster-randomised introduction of the vaccine in Ghana, Kenya, and Malawi
Tabular Data - 3.6 KB - 4 Variables, 154 Observations - UNF:6:+pQzY7MPgoawwYQgIjpikA==
.csvData
List of all cluster/eligibility combinations (used to assign zero counts for an outcome to those cluster/eligibility categories that did not report any events for that outcome)
M24_dataset_readme.ro13.5.2024.txt
May 13, 2024 - Replication Data for: Feasibility, safety, and impact of the RTS,S/AS01E malaria vaccine when implemented through national immunisation programmes: evaluation of cluster-randomised introduction of the vaccine in Ghana, Kenya, and Malawi
Plain Text - 8.3 KB - MD5: c41142239fb151a4983158f2b0407251
DocumentationReadme
M24deaths_data.tab
May 13, 2024 - Replication Data for: Feasibility, safety, and impact of the RTS,S/AS01E malaria vaccine when implemented through national immunisation programmes: evaluation of cluster-randomised introduction of the vaccine in Ghana, Kenya, and Malawi
Tabular Data - 455.7 KB - 8 Variables, 14609 Observations - UNF:6:4DWPk51+n/Bw8+IRWNHOuQ==
.csvData
List of deaths that occurred from vaccine introduction until 30/Apr/2021
M24hosp_data.tab
May 13, 2024 - Replication Data for: Feasibility, safety, and impact of the RTS,S/AS01E malaria vaccine when implemented through national immunisation programmes: evaluation of cluster-randomised introduction of the vaccine in Ghana, Kenya, and Malawi
Tabular Data - 1.2 MB - 18 Variables, 27678 Observations - UNF:6:YpH/o6Vm8RYTPiXRX/P5LA==
.csvData
List of all hospital admissions and any outcomes of interest from vaccine introduction until 30/Apr/2021
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