The absence of a high-resolution, long-term global database for monitoring mangrove forests has created a gap in researchers’ ability to analyze long-term mangrove forest change rates. To address this gap, we present a new global database that tracks annual global mangrove forest change rates at a high spatial resolution since 2000. By synthesizing several remotely sensed databases such as Mangrove Forests of the World, Global Mangrove Watch, and High-Resolution Global Maps of 21st-Century Mangrove Forest Cover Change, this database provides mangrove forest change information at the pixel level. It is not the gold standard global mangrove estimate product for any year, but a consistent and systematic mangrove forest change database across all years. It is a reliable source for annual mangrove forest change data at high resolutions. It can be used for models and analyses at global, continental, national, sub-national, and even highly localized scales. This database is described in detail to facilitate its use by researchers beyond the remote sensing community.