1 to 7 of 7 Results
Mar 19, 2024 - Entomology
Andrade, Alice Oliveira; Santos, Najara Akira Costa dos; Castro, Raphael Brum; Araujo, Isabelle Sousa de; Silva Bastos, Alessandra da; Magi, Felipe Neves; Rodrigues, Moreno Magalhaes de Souza; Pereira, Dhelio Batista; Medeiros, Jansen Fernandes; Araujo, Maisa da Silva, 2024, "Description of malaria vectors (Diptera: Culicidae) in two agricultural settlements in the Western Brazilian Amazon", https://doi.org/10.7910/DVN/AOM6SR, Harvard Dataverse, V1
The majority of malaria cases in South America occur in rural areas of the Amazon region. Although these areas have a significant impact on malaria cases, few entomological studies have been carried out there. This study aimed to describe entomological parameters in settlements in Rondonia State, Brazil. Collections of anopheles were carried out us... |
Mar 19, 2024 - Entomology
Araujo, Maisa da Silva; Andrade, Alice Oliveira; Dos Santos, Najara Akir Costa; Castro, Raphael Brum; Pereira, Dhelio Batista; Rodrigues, Moreno Magalhaes de Sourza; Costa, Glaucilene da Silva; Junior, Antonio Marques Pereira; Carvalho, Luis Paulo Costa; Medeiros, Jansen Fenandes de; Pereira-da-Silva, Luiz Hidelbrando, 2024, "First Observation of Experimental Plasmodium vivax Infection of Three Malaria Vectors from the Brazilian Amazon", https://doi.org/10.7910/DVN/DNOHCZ, Harvard Dataverse, V1
Although malaria is endemic to the Amazon region, little is known about the susceptibility of potential parasite vectors in Brazil. Assessing the vector susceptibility of Anopheles mosquitoes will increase our understanding of parasite-vector interactions and aid the design of vector control strategies. This study assessed the susceptibility of thr... |
Mar 19, 2024
Diniz, Suelen Querioz; Figuiredo, Maria Marta; Costa, Pedro Augusto Carvalho; Martins-Filho, Olido Assis; Teixeira-Carvalho, Andrea; Pereira, Dhelio Batista; Tada, Mauro Shugiro; Afonso, Luis Carlos Crocco; Kohlhoff, Markus; Zani, Carlos Leomar; Gazzinelli, Ricardo Tostes; Oliveira, Fabiano; Antonelli, Lis Ribeiro, 2024, "Adenosine pathway regulates inflammation during Plasmodium vivax infection", https://doi.org/10.7910/DVN/JZSYWH, Harvard Dataverse, V1
Abstract Background: Plasmodium spp. infection triggers the production of inflammatory cytokines that are essential for parasite control, and conversely responsible for symptoms of malaria. Monocytes play a role in host defense against Plasmodium vivax infection and represent the main source of inflammatory cytokines and reactive oxygen species. Th... |
Mar 19, 2024
Costa, Pedro A C; Figueiredo Maria; Diniz, Suelen Q; Peixoto, Ana P M M; Maloy, Kevin; Teixeira-Carvalho, Andrea; Tada, Mauro; Pereira, Dhelio; Gazzinelli, Ricardo; Antonelli, Lis, 2024, "Plasmodium vivax Infection Impairs Regulatory T-Cell Suppressive Function During Acute Malaria", https://doi.org/10.7910/DVN/GJE2PN, Harvard Dataverse, V1
Abstract The balance between pro- and antiinflammatory mechanisms is essential to limit immune-mediated pathology, and CD4+ forkhead box P3 (Foxp3+) regulatory T cells (Treg) play an important role in this process. The expression of inhibitory receptors regulates cytokine production by Plasmodium vivax-specific T cells. Our goal was to assess the i... |
Mar 19, 2024
Figueiredo, Maria Marta; Costa, Pedro Augusto Carvalho; Diniz, Suelen Queiroz; Henriques, Priscilla Miranda; Kano, Flora Satiko; Tada, Mauro Sugiro; Pereira, Dhelio Batista; Soares, Irene Silva; Martins-Filho, Olindo Assis; Jankovic, Dragana; Gazzinelli, Ricardo Tostes; Antonelli, Lis Ribeiro do Valle, 2024, "T follicular helper cells regulate the activation of B lymphocytes and antibody production during Plasmodium vivax infection", https://doi.org/10.7910/DVN/HZHPTT, Harvard Dataverse, V1
Although the importance of humoral immunity to malaria has been established, factors that control antibody production are poorly understood. Follicular helper T cells (Tfh cells) are pivotal for generating high-affinity, long-lived antibody responses. While it has been proposed that expansion of antigen-specific Tfh cells, interleukin (IL) 21 produ... |
Nov 28, 2023
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Nov 28, 2023
Hojo-Souza, Natalia Satchiko; Orestes de Azevedo, Patrick; Teixeira de Castro, Julia; Teixeira-Carvalho, Andrea; Lieberman, Judy; Junqueira, Caroline; Gazzinelli, Ricardo, 2023, "Contributions of IFN-gamma and granulysin to the clearance of Plasmodium yoelii blood stage", https://doi.org/10.7910/DVN/ONAWGV, Harvard Dataverse, V1
Abstract P. vivax-infected Retics (iRetics) express human leukocyte antigen class I (HLA-I), are recognized by CD8+ T cells and killed by granulysin (GNLY) and granzymes. However, how Plasmodium infection induces MHC-I expression on Retics is unknown. In addition, whether GNLY helps control Plasmodium infection in vivo has not been studied. Here, w... |
