O'Tierney-Ginn Lab

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Metabolomic Signatures of Low and High Adiposity Neonates Differ based on Maternal BMI Oct 7, 2021 - Harvard Dataverse O'tierney-Ginn, Perrie Faye, 2021, "Metabolomic Signatures of Low and High Adiposity Neonates Differ based on Maternal BMI", https://doi.org/10.7910/DVN/7A0H05, Harvard Dataverse, V1, UNF:6:NxNX38pV3PFL/+OD221qfA== [fileUNF] Variation in neonatal adiposity within maternal BMI groups is underappreciated, and it remains unclear whether the metabolic impairments at birth are an outcome of maternal obesity or excess fetal fat accrual. We examined the hypothesis that CB metabolites associated with fetal fat accrual differ between offspring of normal weight and obese women....
Placental miR-3940-3p is associated with maternal insulin resistance in late pregnancy Mar 26, 2021 O'tierney-Ginn, Perrie Faye; Alvarado, Fernanda, 2021, "Placental miR-3940-3p is associated with maternal insulin resistance in late pregnancy", https://doi.org/10.7910/DVN/SSSL2D, Harvard Dataverse, V1 Context: An increase in maternal insulin resistance (IR) during pregnancy is essential for normal fetal growth. The mechanisms underlying this metabolic adaptation to pregnancy are poorly understood. Placenta factors are believed to instigate and maintain these metabolic changes, as IR decreases shortly after delivery. Methylation of placental gene...

Metabolomic Signatures of Low and High Adiposity Neonates Differ based on Maternal BMI

Oct 7, 2021 - Harvard Dataverse

O'tierney-Ginn, Perrie Faye, 2021, "Metabolomic Signatures of Low and High Adiposity Neonates Differ based on Maternal BMI", https://doi.org/10.7910/DVN/7A0H05, Harvard Dataverse, V1, UNF:6:NxNX38pV3PFL/+OD221qfA== [fileUNF]

Variation in neonatal adiposity within maternal BMI groups is underappreciated, and it remains unclear whether the metabolic impairments at birth are an outcome of maternal obesity or excess fetal fat accrual. We examined the hypothesis that CB metabolites associated with fetal fat accrual differ between offspring of normal weight and obese women....

Placental miR-3940-3p is associated with maternal insulin resistance in late pregnancy

Mar 26, 2021

O'tierney-Ginn, Perrie Faye; Alvarado, Fernanda, 2021, "Placental miR-3940-3p is associated with maternal insulin resistance in late pregnancy", https://doi.org/10.7910/DVN/SSSL2D, Harvard Dataverse, V1

Context: An increase in maternal insulin resistance (IR) during pregnancy is essential for normal fetal growth. The mechanisms underlying this metabolic adaptation to pregnancy are poorly understood. Placenta factors are believed to instigate and maintain these metabolic changes, as IR decreases shortly after delivery. Methylation of placental gene...

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