O'Tierney-Ginn Lab

We study how maternal-placental cross-talk impacts fetal growth. Our lab website is: www.placentascience.com

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1 to 8 of 8 Results

Metabolomic Signatures of Low and High Adiposity Neonates Differ based on Maternal BMI Oct 7, 2021 - Harvard Dataverse O'tierney-Ginn, Perrie Faye, 2021, "Metabolomic Signatures of Low and High Adiposity Neonates Differ based on Maternal BMI", https://doi.org/10.7910/DVN/7A0H05, Harvard Dataverse, V1, UNF:6:NxNX38pV3PFL/+OD221qfA== [fileUNF] Variation in neonatal adiposity within maternal BMI groups is underappreciated, and it remains unclear whether the metabolic impairments at birth are an outcome of maternal obesity or excess fetal fat accrual. We examined the hypothesis that CB metabolites associated with fetal fat accrual differ between offspring of normal weight and obese women....
Supplemental Table 1.docx Oct 7, 2021 - Metabolomic Signatures of Low and High Adiposity Neonates Differ based on Maternal BMI MS Word - 12.1 KB - MD5: 6da337c4f2362e2ec7e2ccdd86522023 Multivariate Pairwise Comparisons of Global Metabolomics of cord blood from high- and low- adiposity babies born from lean and obese mothers.
Supplemental Table 2.docx Oct 7, 2021 - Metabolomic Signatures of Low and High Adiposity Neonates Differ based on Maternal BMI MS Word - 14.4 KB - MD5: 7bf5638cad028d39c048dc437505e648 Performance statistics for partial least squares-discriminant analysis (PLS-DA) models.
Supplemental Table 3.tab Oct 7, 2021 - Metabolomic Signatures of Low and High Adiposity Neonates Differ based on Maternal BMI Tabular Data - 62.9 KB - 7 Variables, 540 Observations - UNF:6:NxNX38pV3PFL/+OD221qfA== Feature selection statistics from partial least squares-discriminant analysis (PLS-DA) models.
Placental miR-3940-3p is associated with maternal insulin resistance in late pregnancy Mar 26, 2021 O'tierney-Ginn, Perrie Faye; Alvarado, Fernanda, 2021, "Placental miR-3940-3p is associated with maternal insulin resistance in late pregnancy", https://doi.org/10.7910/DVN/SSSL2D, Harvard Dataverse, V1 Context: An increase in maternal insulin resistance (IR) during pregnancy is essential for normal fetal growth. The mechanisms underlying this metabolic adaptation to pregnancy are poorly understood. Placenta factors are believed to instigate and maintain these metabolic changes, as IR decreases shortly after delivery. Methylation of placental gene...
SupplTable1_Alvarado 2021.docx Mar 26, 2021 - Placental miR-3940-3p is associated with maternal insulin resistance in late pregnancy MS Word - 12.9 KB - MD5: 071fd94829a26f778c7a0f9c3451483b Demographic characteristics of the small RNA sequencing subset (N=40)
SupplTable2_Alvarado 2021.docx Mar 26, 2021 - Placental miR-3940-3p is associated with maternal insulin resistance in late pregnancy MS Word - 21.2 KB - MD5: 5e598274d70e32d32c7590f71372c4b7 Placental miRNAs expression levels correlated with maternal HOMA-IR in late pregnancy (Pearson estimation and P-values shown) (columns A, B & C) and miRNA predicted to target genes nearest to CpG sites at which placental DNA methylation was associated with maternal Matsuda index (reciprocal to insulin resistance) in mid-pregnancy (Hivert et al., 20...
SupplTable3_Alvarado 2021.docx Mar 26, 2021 - Placental miR-3940-3p is associated with maternal insulin resistance in late pregnancy MS Word - 12.5 KB - MD5: 1856fdeefa85e75ec0b5a887077a5fc0 Primer information

Metabolomic Signatures of Low and High Adiposity Neonates Differ based on Maternal BMI

Oct 7, 2021 - Harvard Dataverse

O'tierney-Ginn, Perrie Faye, 2021, "Metabolomic Signatures of Low and High Adiposity Neonates Differ based on Maternal BMI", https://doi.org/10.7910/DVN/7A0H05, Harvard Dataverse, V1, UNF:6:NxNX38pV3PFL/+OD221qfA== [fileUNF]

Variation in neonatal adiposity within maternal BMI groups is underappreciated, and it remains unclear whether the metabolic impairments at birth are an outcome of maternal obesity or excess fetal fat accrual. We examined the hypothesis that CB metabolites associated with fetal fat accrual differ between offspring of normal weight and obese women....

Supplemental Table 1.docx

Oct 7, 2021 - Metabolomic Signatures of Low and High Adiposity Neonates Differ based on Maternal BMI

MS Word - 12.1 KB -

Multivariate Pairwise Comparisons of Global Metabolomics of cord blood from high- and low- adiposity babies born from lean and obese mothers.

Supplemental Table 2.docx

Oct 7, 2021 - Metabolomic Signatures of Low and High Adiposity Neonates Differ based on Maternal BMI

MS Word - 14.4 KB -

Performance statistics for partial least squares-discriminant analysis (PLS-DA) models.

Supplemental Table 3.tab

Oct 7, 2021 - Metabolomic Signatures of Low and High Adiposity Neonates Differ based on Maternal BMI

Tabular Data - 62.9 KB - 7 Variables, 540 Observations -

Feature selection statistics from partial least squares-discriminant analysis (PLS-DA) models.

Placental miR-3940-3p is associated with maternal insulin resistance in late pregnancy

Mar 26, 2021

O'tierney-Ginn, Perrie Faye; Alvarado, Fernanda, 2021, "Placental miR-3940-3p is associated with maternal insulin resistance in late pregnancy", https://doi.org/10.7910/DVN/SSSL2D, Harvard Dataverse, V1

Context: An increase in maternal insulin resistance (IR) during pregnancy is essential for normal fetal growth. The mechanisms underlying this metabolic adaptation to pregnancy are poorly understood. Placenta factors are believed to instigate and maintain these metabolic changes, as IR decreases shortly after delivery. Methylation of placental gene...

SupplTable1_Alvarado 2021.docx

Mar 26, 2021 - Placental miR-3940-3p is associated with maternal insulin resistance in late pregnancy

MS Word - 12.9 KB -

Demographic characteristics of the small RNA sequencing subset (N=40)

SupplTable2_Alvarado 2021.docx

Mar 26, 2021 - Placental miR-3940-3p is associated with maternal insulin resistance in late pregnancy

MS Word - 21.2 KB -

Placental miRNAs expression levels correlated with maternal HOMA-IR in late pregnancy (Pearson estimation and P-values shown) (columns A, B & C) and miRNA predicted to target genes nearest to CpG sites at which placental DNA methylation was associated with maternal Matsuda index (reciprocal to insulin resistance) in mid-pregnancy (Hivert et al., 20...

SupplTable3_Alvarado 2021.docx

Mar 26, 2021 - Placental miR-3940-3p is associated with maternal insulin resistance in late pregnancy

MS Word - 12.5 KB -

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